Search Results - "Sivolapenko, Gregory B."

VEGF-A and ICAM-1 Gene Polymorphisms as Predictors of Clinical Outcome to First-Line Bevacizumab-Based Treatment in Metastatic Colorectal Cancer by Papachristos, Apostolos, Kemos, Polychronis, Katsila, Theodora, Panoilia, Eirini, Patrinos, George P, Kalofonos, Haralabos, Sivolapenko, Gregory B

“…Bevacizumab is used to treat metastatic colorectal cancer (mCRC). However, there are still no available predictors of clinical outcomes. We investigated…”
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Machine learning‐guided covariate selection for time‐to‐event models developed from a small sample of real‐world patients receiving bevacizumab treatment by Karatza, Eleni, Papachristos, Apostolos, Sivolapenko, Gregory B., Gonzalez, Daniel

“…Therapeutic outcomes in patients with metastatic colorectal cancer (mCRC) receiving bevacizumab treatment are highly variable, and a reliable predictive factor…”
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Aqueous Humour Ofloxacin Concentration after Topical Instillation in Patients with Dry Eye Disease by Kagkelaris, Konstantinos, El Mubarak, Mohamed A, Plotas, Panagiotis, Panaretos, Dimitris, Panayiotakopoulos, George D, Sivolapenko, Gregory B, Georgakopoulos, Constantinos D

“…Background and Objectives: A prospective, randomized clinical trial was conducted to evaluate the concentration of ofloxacin in the aqueous humour (AqH) of…”
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Pharmacogenomics, Pharmacokinetics and Circulating Proteins As Biomarkers for Bevacizumab Treatment Optimization in Patients with Cancer: A Review by Papachristos, Apostolos, Sivolapenko, Gregory B

“…Bevacizumab is a monoclonal antibody that targets VEGF-A and inhibits tumor angiogenesis. Bevacizumab is approved for the treatment of various cancer,…”
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Development and validation of analytical methodologies for the quantification of PCK3145 and PEG-PCK3145 in mice by Danika, Charikleia, El Mubarak, Mohamed A., Leontari, Iliana, Sivolapenko, Gregory B.

“…PCK3145 is an anti-metastatic synthetic peptide against prostate cancer. The objective of the study is to develop and validate novel and sensitive methods for…”
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Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma by Perryman, Richard, Renziehausen, Alexander, Shaye, Hamidreza, Kostagianni, Androniki D, Tsiailanis, Antonis D, Thorne, Thomas, Chatziathanasiadou, Maria V, Sivolapenko, Gregory B, El Mubarak, Mohamed Ahmed, Han, Gye Won, Zarzycka, Barbara, Katritch, Vsevolod, Lebon, Guillaume, Nigro, Cristiana Lo, Lattanzio, Laura, Morse, Sophie V, Choi, James J, O'Neill, Kevin, Kanaki, Zoi, Klinakis, Apostolos, Crook, Tim, Cherezov, Vadim, Tzakos, Andreas G, Syed, Nelofer

“…Glioblastoma (GBM) is an aggressive malignant primary brain tumor with limited therapeutic options. We show that the angiotensin II (AngII) type 2 receptor…”
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Inhibition of the angiotensin II type 2 receptor AT 2 R is a novel therapeutic strategy for glioblastoma by Perryman, Richard, Renziehausen, Alexander, Shaye, Hamidreza, Kostagianni, Androniki D, Tsiailanis, Antonis D, Thorne, Thomas, Chatziathanasiadou, Maria V, Sivolapenko, Gregory B, El Mubarak, Mohamed Ahmed, Han, Gye Won, Zarzycka, Barbara, Katritch, Vsevolod, Lebon, Guillaume, Lo Nigro, Cristiana, Lattanzio, Laura, Morse, Sophie V, Choi, James J, O'Neill, Kevin, Kanaki, Zoi, Klinakis, Apostolos, Crook, Tim, Cherezov, Vadim, Tzakos, Andreas G, Syed, Nelofer

“…Glioblastoma (GBM) is an aggressive malignant primary brain tumor with limited therapeutic options. We show that the angiotensin II (AngII) type 2 receptor (AT…”
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In vivo quantification and pharmacokinetic studies of cotinine in mice after smoke exposure by LC–MS/MS by El Mubarak, Mohamed A., Danika, Charikleia, Cachon, Charlyne, Korovila, Charalambia, Atsopardi, Korina, Panagopoulos, Nikolaos, Margarity, Marigoula, Poulas, Konstantinos, Sivolapenko, Gregory B.

“…A sensitive analytical method was developed and validated for the quantification of cotinine in mouse plasma after exposure to smoke of 0.5, 1.0, and 1.5…”
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Development and validation of simple step protein precipitation UHPLC-MS/MS methods for quantitation of temozolomide in cancer patient plasma samples by El Mubarak, Mohamed A., Stylos, Evgenios K., Chatziathanasiadou, Maria V., Danika, Charikleia, Alexiou, George A., Tsekeris, Periklis, Renziehausen, Alexander, Crook, Tim, Syed, Nelofer, Sivolapenko, Gregory B., Tzakos, Andreas G.

“…•Development of two cost-effective methods for quantitation of TMZ in human plasma.•A simple protein precipitation step is used in the sample preparation.•The…”
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Development of a validated LC-MS/MS method for the in vitro and in vivo quantitation of sunitinib in glioblastoma cells and cancer patients by Chatziathanasiadou, Maria V., Stylos, Evgenios K., Giannopoulou, Efstathia, Spyridaki, Maria-Helen, Briasoulis, Evangelos, Kalofonos, Haralabos P., Crook, Tim, Syed, Nelofer, Sivolapenko, Gregory B., Tzakos, Andreas G.

“…•A cost-effective and rapid bioanalytical method for quantitation of sunitinib.•A simple protein precipitation step is used in the sample preparation.•The…”
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Development of a novel conjugatable sunitinib analogue validated through in vitro and in vivo preclinical settings by El Mubarak, Mohamed A., Leontari, Iliana, Efstathia, Giannopoulou, Vrettos, Eirinaios I., Shaikh, Abdul kadar, Konstantinos, Siatis E., Danika, Charikleia, Kalofonos, Haralabos P., Tzakos, Andreas G., Sivolapenko, Gregory B.

“…Sunitinib is an oral FDA/EMEA approved multi-targeted tyrosine kinase inhibitor. It possesses anti-angiogenic and antitumor activity against a variety of…”
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Co-administration of succinylated gelatine with a (99m)Tc-bombesin analogue, effects on pharmacokinetics and tumor uptake by Liolios, Christos C, Xanthopoulos, Stavros, Loudos, George, Varvarigou, Alexandra D, Sivolapenko, Gregory B

“…The bombesin analogue, [(99m)Tc-GGC]-(Ornithine)3-BN(2-14), (99m)Tc-BN-O, targeting gastrin releasing peptide receptors (GRPrs) on the surface of tumors, was…”
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Structural modifications of 99mTc-labelled bombesin-like peptides for optimizing pharmacokinetics in prostate tumor targeting by Liolios, Christos C., Fragogeorgi, Eirini A., Zikos, Christos, Loudos, George, Xanthopoulos, Stavros, Bouziotis, Penelope, Paravatou-Petsotas, Maria, Livaniou, Evangelia, Varvarigou, Alexandra D., Sivolapenko, Gregory B.

“…The main goal of the present study was to investigate the importance of the addition of a positively charged aa in the naturally occurring Bombesin (BN)…”
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Neoadjuvant therapy in locally advanced breast cancer: 99mTc-MIBI mammoscintigraphy is not a reliable technique to predict therapy response by Travaini, Laura Lavinia, Baio, Silvia Melania, Cremonesi, Marta, Cicco, Concetta De, Ferrari, Mahila, Trifirò, Giuseppe, Prisco, Gennaro, Viale, Giuseppe, Colleoni, Marco Angelo, Radice, Davide, Sivolapenko, Gregory B, Paganelli, Giovanni

“…Summary Mammoscintigraphy (MMS) has been indicated as a useful tool in predicting response to therapy in cancer. However, contrasting results have been…”
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Imaging of metastatic melanoma utilising a technetium-99m labelled RGD-containing synthetic peptide by Sivolapenko, G B, Skarlos, D, Pectasides, D, Stathopoulou, E, Milonakis, A, Sirmalis, G, Stuttle, A, Courtenay-Luck, N S, Konstantinides, K, Epenetos, A A

“…Integrins are cell-surface glycoproteins found in different forms on all cells except erythrocytes. Integrins bind to cell adhesion molecules and to proteins…”
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Co-administration of succinylated gelatine with a 99mTc-bombesin analogue, effects on pharmacokinetics and tumor uptake by Liolios, Christos C., Xanthopoulos, Stavros, Loudos, George, Varvarigou, Alexandra D., Sivolapenko, Gregory B.

“…The bombesin analogue, [99mTc-GGC]-(Ornithine)3-BN(2-14), 99mTc-BN-O, targeting gastrin releasing peptide receptors (GRPrs) on the surface of tumors, was…”
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Co-administration of succinylated gelatine with a 99m Tc-bombesin analogue, effects on pharmacokinetics and tumor uptake by Liolios, Christos C., Xanthopoulos, Stavros, Loudos, George, Varvarigou, Alexandra D., Sivolapenko, Gregory B.

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Co-administration of succinylated gelatine with a99m Tc-bombesin analogue, effects on pharmacokinetics and tumor uptake by Liolios, Christos C, Xanthopoulos, Stavros, Loudos, George, Varvarigou, Alexandra D, Sivolapenko, Gregory B

“…Abstract The bombesin analogue, [99m Tc-GGC]-(Ornithine)3 -BN(2-14), 99m Tc-BN-O , targeting gastrin releasing peptide receptors (GRPrs) on the surface of…”
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Clearance of 131I-labeled murine monoclonal antibody from patients' blood by intravenous human anti-murine immunoglobulin antibody by STEWART, J. S. W, SIVOLAPENKO, G. B, HIRD, V, DAVIES, K. A. A, WALPORT, M, RITTER, M. A, EPENETOS, A. A

“…Five patients treated with intraperitoneal 131I-labeled mouse monoclonal antibody for ovarian cancer also received i.v. exogenous polyclonal human anti-murine…”
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A study of in vivo immune complex formation and clearance in man by Davies, KA, Hird, V, Stewart, S, Sivolapenko, GB, Jose, P, Epenetos, AA, Walport, MJ

“…C and CR1 have been shown to participate in the clearance of injected, preformed, immune complexes in humans and in non-human primates. Their role in the…”
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