Search Results - "Sivolapenko, Gregory"

Pharmacogenetics in Model-Based Optimization of Bevacizumab Therapy for Metastatic Colorectal Cancer by Papachristos, Apostolos, Karatza, Eleni, Kalofonos, Haralabos, Sivolapenko, Gregory

“…Vascular endothelial growth factor A (VEGF-A) and intercellular adhesion molecule 1 (ICAM-1) are significant regulators of angiogenesis, an important…”
Get full text

Characterization and Biological Evaluation of Propolis from Poland by Popova, Milena, Giannopoulou, Efstathia, Skalicka-Woźniak, Krystyna, Graikou, Konstantia, Widelski, Jaroslaw, Bankova, Vassya, Kalofonos, Haralabos, Sivolapenko, Gregory, Gaweł-Bęben, Katarzyna, Antosiewicz, Beata, Chinou, Ioanna

“…In this study, we assessed the therapeutic potential of propolis from Poland and performed chemical analysis by GC-MS, as well as determined its botanical…”
Get full text

VEGF-A and ICAM-1 Gene Polymorphisms as Predictors of Clinical Outcome to First-Line Bevacizumab-Based Treatment in Metastatic Colorectal Cancer by Papachristos, Apostolos, Kemos, Polychronis, Katsila, Theodora, Panoilia, Eirini, Patrinos, George P, Kalofonos, Haralabos, Sivolapenko, Gregory B

“…Bevacizumab is used to treat metastatic colorectal cancer (mCRC). However, there are still no available predictors of clinical outcomes. We investigated…”
Get full text

Inhibition of the angiotensin II type 2 receptor AT 2 R is a novel therapeutic strategy for glioblastoma by Perryman, Richard, Renziehausen, Alexander, Shaye, Hamidreza, Kostagianni, Androniki D, Tsiailanis, Antonis D, Thorne, Thomas, Chatziathanasiadou, Maria V, Sivolapenko, Gregory B, El Mubarak, Mohamed Ahmed, Han, Gye Won, Zarzycka, Barbara, Katritch, Vsevolod, Lebon, Guillaume, Lo Nigro, Cristiana, Lattanzio, Laura, Morse, Sophie V, Choi, James J, O'Neill, Kevin, Kanaki, Zoi, Klinakis, Apostolos, Crook, Tim, Cherezov, Vadim, Tzakos, Andreas G, Syed, Nelofer

“…Glioblastoma (GBM) is an aggressive malignant primary brain tumor with limited therapeutic options. We show that the angiotensin II (AngII) type 2 receptor (AT…”
Get full text

Pharmacogenomics, Pharmacokinetics and Circulating Proteins As Biomarkers for Bevacizumab Treatment Optimization in Patients with Cancer: A Review by Papachristos, Apostolos, Sivolapenko, Gregory B

“…Bevacizumab is a monoclonal antibody that targets VEGF-A and inhibits tumor angiogenesis. Bevacizumab is approved for the treatment of various cancer,…”
Get full text

Machine learning‐guided covariate selection for time‐to‐event models developed from a small sample of real‐world patients receiving bevacizumab treatment by Karatza, Eleni, Papachristos, Apostolos, Sivolapenko, Gregory B., Gonzalez, Daniel

“…Therapeutic outcomes in patients with metastatic colorectal cancer (mCRC) receiving bevacizumab treatment are highly variable, and a reliable predictive factor…”
Get full text

Development and validation of analytical methodologies for the quantification of PCK3145 and PEG-PCK3145 in mice by Danika, Charikleia, El Mubarak, Mohamed A., Leontari, Iliana, Sivolapenko, Gregory B.

“…PCK3145 is an anti-metastatic synthetic peptide against prostate cancer. The objective of the study is to develop and validate novel and sensitive methods for…”
Get full text

Inhibition of the angiotensin II type 2 receptor AT2R is a novel therapeutic strategy for glioblastoma by Perryman, Richard, Renziehausen, Alexander, Shaye, Hamidreza, Kostagianni, Androniki D, Tsiailanis, Antonis D, Thorne, Thomas, Chatziathanasiadou, Maria V, Sivolapenko, Gregory B, El Mubarak, Mohamed Ahmed, Han, Gye Won, Zarzycka, Barbara, Katritch, Vsevolod, Lebon, Guillaume, Nigro, Cristiana Lo, Lattanzio, Laura, Morse, Sophie V, Choi, James J, O'Neill, Kevin, Kanaki, Zoi, Klinakis, Apostolos, Crook, Tim, Cherezov, Vadim, Tzakos, Andreas G, Syed, Nelofer

“…Glioblastoma (GBM) is an aggressive malignant primary brain tumor with limited therapeutic options. We show that the angiotensin II (AngII) type 2 receptor…”
Get full text

Aqueous Humour Ofloxacin Concentration after Topical Instillation in Patients with Dry Eye Disease by Kagkelaris, Konstantinos, El Mubarak, Mohamed A, Plotas, Panagiotis, Panaretos, Dimitris, Panayiotakopoulos, George D, Sivolapenko, Gregory B, Georgakopoulos, Constantinos D

“…Background and Objectives: A prospective, randomized clinical trial was conducted to evaluate the concentration of ofloxacin in the aqueous humour (AqH) of…”
Get full text

In vivo quantification and pharmacokinetic studies of cotinine in mice after smoke exposure by LC–MS/MS by El Mubarak, Mohamed A., Danika, Charikleia, Cachon, Charlyne, Korovila, Charalambia, Atsopardi, Korina, Panagopoulos, Nikolaos, Margarity, Marigoula, Poulas, Konstantinos, Sivolapenko, Gregory B.

“…A sensitive analytical method was developed and validated for the quantification of cotinine in mouse plasma after exposure to smoke of 0.5, 1.0, and 1.5…”
Get full text

A pharmacokinetic binding model for bevacizumab and VEGF165 in colorectal cancer patients by Panoilia, Eirini, Schindler, Emilie, Samantas, Epaminontas, Aravantinos, Gerasimos, Kalofonos, Haralabos P., Christodoulou, Christos, Patrinos, George P., Friberg, Lena E., Sivolapenko, Gregory

“…Purpose To characterize the population pharmacokinetics of bevacizumab, its binding properties to VEGF 165 and the effect of demographic data and VEGF-A…”
Get full text

Development and validation of simple step protein precipitation UHPLC-MS/MS methods for quantitation of temozolomide in cancer patient plasma samples by El Mubarak, Mohamed A., Stylos, Evgenios K., Chatziathanasiadou, Maria V., Danika, Charikleia, Alexiou, George A., Tsekeris, Periklis, Renziehausen, Alexander, Crook, Tim, Syed, Nelofer, Sivolapenko, Gregory B., Tzakos, Andreas G.

“…•Development of two cost-effective methods for quantitation of TMZ in human plasma.•A simple protein precipitation step is used in the sample preparation.•The…”
Get full text

Development of a validated LC-MS/MS method for the in vitro and in vivo quantitation of sunitinib in glioblastoma cells and cancer patients by Chatziathanasiadou, Maria V., Stylos, Evgenios K., Giannopoulou, Efstathia, Spyridaki, Maria-Helen, Briasoulis, Evangelos, Kalofonos, Haralabos P., Crook, Tim, Syed, Nelofer, Sivolapenko, Gregory B., Tzakos, Andreas G.

“…•A cost-effective and rapid bioanalytical method for quantitation of sunitinib.•A simple protein precipitation step is used in the sample preparation.•The…”
Get full text

Development of a novel conjugatable sunitinib analogue validated through in vitro and in vivo preclinical settings by El Mubarak, Mohamed A., Leontari, Iliana, Efstathia, Giannopoulou, Vrettos, Eirinaios I., Shaikh, Abdul kadar, Konstantinos, Siatis E., Danika, Charikleia, Kalofonos, Haralabos P., Tzakos, Andreas G., Sivolapenko, Gregory B.

“…Sunitinib is an oral FDA/EMEA approved multi-targeted tyrosine kinase inhibitor. It possesses anti-angiogenic and antitumor activity against a variety of…”
Get full text

Co-administration of succinylated gelatine with a (99m)Tc-bombesin analogue, effects on pharmacokinetics and tumor uptake by Liolios, Christos C, Xanthopoulos, Stavros, Loudos, George, Varvarigou, Alexandra D, Sivolapenko, Gregory B

“…The bombesin analogue, [(99m)Tc-GGC]-(Ornithine)3-BN(2-14), (99m)Tc-BN-O, targeting gastrin releasing peptide receptors (GRPrs) on the surface of tumors, was…”
Get full text

Structural modifications of 99mTc-labelled bombesin-like peptides for optimizing pharmacokinetics in prostate tumor targeting by Liolios, Christos C., Fragogeorgi, Eirini A., Zikos, Christos, Loudos, George, Xanthopoulos, Stavros, Bouziotis, Penelope, Paravatou-Petsotas, Maria, Livaniou, Evangelia, Varvarigou, Alexandra D., Sivolapenko, Gregory B.

“…The main goal of the present study was to investigate the importance of the addition of a positively charged aa in the naturally occurring Bombesin (BN)…”
Get full text

Intraoperative Avidination for Radionuclide Therapy: A Prospective New Development to Accelerate Radiotherapy in Breast Cancer by PAGANELLI, Giovanni, FERRARI, Mahila, FIORENZA, Maurizio, CHINOL, Marco, PAPI, Stefano, ZANNA, Claudio, CARMINATI, Paolo, VERONESI, Umberto, RAVASI, Laura, CREMONESI, Marta, DE CICCO, Concetta, GALIMBERTI, Viviana, SIVOLAPENKO, Gregory, LUINI, Alberto, DE SANTIS, Rita, LAVINIA TRAVAINI, Laura

“…Purpose: In a continuous effort to seek for anticancer treatments with minimal side effects, we aim at proving the feasibility of the Intraoperative…”
Get full text

Correlation Between Bevacizumab Exposure and Survival in Patients with Metastatic Colorectal Cancer by Papachristos, Apostolos, Kemos, Polychronis, Kalofonos, Haralabos, Sivolapenko, Gregory

“…Background Bevacizumab treatment is subject to large interpatient variability in efficacy, which may partly be explained by differences in complex bevacizumab…”
Get full text

Neoadjuvant therapy in locally advanced breast cancer: 99mTc-MIBI mammoscintigraphy is not a reliable technique to predict therapy response by Travaini, Laura Lavinia, Baio, Silvia Melania, Cremonesi, Marta, Cicco, Concetta De, Ferrari, Mahila, Trifirò, Giuseppe, Prisco, Gennaro, Viale, Giuseppe, Colleoni, Marco Angelo, Radice, Davide, Sivolapenko, Gregory B, Paganelli, Giovanni

“…Summary Mammoscintigraphy (MMS) has been indicated as a useful tool in predicting response to therapy in cancer. However, contrasting results have been…”
Get full text

Imaging of metastatic melanoma utilising a technetium-99m labelled RGD-containing synthetic peptide by Sivolapenko, G B, Skarlos, D, Pectasides, D, Stathopoulou, E, Milonakis, A, Sirmalis, G, Stuttle, A, Courtenay-Luck, N S, Konstantinides, K, Epenetos, A A

“…Integrins are cell-surface glycoproteins found in different forms on all cells except erythrocytes. Integrins bind to cell adhesion molecules and to proteins…”
Get full text