Search Results - "Sivaraman, J"

Exploring the “Other” subfamily of HECT E3-ligases for therapeutic intervention by Singh, Sunil, Ng, Joel, Sivaraman, J.

“…The HECT E3 ligase family regulates key cellular signaling pathways, with its 28 members divided into three subfamilies: NEDD4 subfamily (9 members), HERC…”
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Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage by Jianwei, Li, Jobichen, Chacko, Machida, Satoru, Meng, Sun, Read, Randy J, Hongying, Chen, Jian, Shi, Yuan, Yuren Adam, Sivaraman, J

“…Cas12a is a programmable nuclease for adaptive immunity against invading nucleic acids in CRISPR-Cas systems. Here, we report the crystal structures of apo…”
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Linkers in the structural biology of protein–protein interactions by Reddy Chichili, Vishnu Priyanka, Kumar, Veerendra, Sivaraman, J.

“…Linkers or spacers are short amino acid sequences created in nature to separate multiple domains in a single protein. Most of them are rigid and function to…”
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Structural Basis of SARS-CoV-2 and SARS-CoV Antibody Interactions by Gavor, Edem, Choong, Yeu Khai, Er, Shi Yin, Sivaraman, Hariharan, Sivaraman, J.

“…The 2019 coronavirus pandemic remains a major public health concern. Neutralizing antibodies (nAbs) represent a cutting-edge antiviral strategy. We focus here…”
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Structure of LNX1:Ubc13~Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1 by Nayak, Digant, Sivaraman, J.

“…LNX1 (ligand of numb protein-X1) is a RING and PDZ domain-containing E3 ubiquitin ligase that ubiquitinates human c-Src kinase. Here, we report the…”
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Identification of Aedes aegypti salivary gland proteins interacting with human immune receptor proteins by Gavor, Edem, Choong, Yeu Khai, Liu, Yonghao, Pompon, Julien, Ooi, Eng Eong, Mok, Yu Keung, Liu, Haiyan, Kini, R Manjunatha, Sivaraman, J

“…Mosquito saliva proteins modulate the human immune and hemostatic systems and control mosquito-borne pathogenic infections. One mechanism through which…”
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Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activities in vitro by Singh, Sunil, Ng, Joel, Nayak, Digant, Sivaraman, J.

“…The HECT E3 ligase family comprises three subfamilies: NEDD4 E3 ubiquitin protein ligase (NEDD4), HECT and RLD domain–containing E3 ubiquitin protein ligase…”
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Structural basis for the distinct roles of non-conserved Pro116 and conserved Tyr124 of BCH domain of yeast p50RhoGAP by Shankar, Srihari, Chew, Ti Weng, Chichili, Vishnu Priyanka Reddy, Low, Boon Chuan, Sivaraman, J.

“…p50RhoGAP is a key protein that interacts with and downregulates the small GTPase RhoA. p50RhoGAP is a multifunctional protein containing the BNIP-2 and…”
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Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism by Thangavelu, K, Pan, Catherine Qiurong, Karlberg, Tobias, Balaji, Ganapathy, Uttamchandani, Mahesh, Suresh, Valiyaveettil, Schüler, Herwig, Low, Boon Chuan, Sivaraman, J

“…Besides thriving on altered glucose metabolism, cancer cells undergo glutaminolysis to meet their energy demands. As the first enzyme in catalyzing…”
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Structural Basis of SARS-CoV-2- and SARS-CoV-Receptor Binding and Small-Molecule Blockers as Potential Therapeutics by Sivaraman, Hariharan, Er, Shi Yin, Choong, Yeu Khai, Gavor, Edem, Sivaraman, J

“…Over the past two decades, deadly coronaviruses, with the most recent being the severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) 2019…”
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Sensing for survival: specialised regulatory mechanisms of Type III secretion systems in Gram‐negative pathogens by Manisha, Yadav, Srinivasan, Mahalashmi, Jobichen, Chacko, Rosenshine, Ilan, Sivaraman, J.

“…ABSTRACT For centuries, Gram‐negative pathogens have infected the human population and been responsible for numerous diseases in animals and plants. Despite…”
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A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase by Shankar, Srihari, Ramachandran, Sarath, Tulsian, Nikhil, Radhakrishnan, Sridhar, Jobichen, Chacko, Sivaraman, J.

“…Glutaminase catalyses the metabolic process called glutaminolysis. Cancer cells harness glutaminolysis to increase energy reserves under stressful conditions…”
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Two-component PhoB-PhoR Regulatory System and Ferric Uptake Regulator Sense Phosphate and Iron to Control Virulence Genes in Type III and VI Secretion Systems of Edwardsiella tarda by Chakraborty, Smarajit, Sivaraman, J., Leung, Ka Yin, Mok, Yu-Keung

“…Inorganic phosphate (Pi) and iron are essential nutrients that are depleted by vertebrates as a protective mechanism against bacterial infection. This…”
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Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA) by Thangavelu, K., Chong, Qing Yun, Low, Boon Chuan, Sivaraman, J.

“…Glutaminase is a metabolic enzyme responsible for glutaminolysis, a process harnessed by cancer cells to feed their accelerated growth and proliferation. Among…”
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Berberine Targets Assembly of Escherichia coli Cell Division Protein FtsZ by Domadia, Prerna N, Bhunia, Anirban, Sivaraman, J, Swarup, Sanjay, Dasgupta, Debjani

“…The ever increasing problem of antibiotic resistance necessitates a search for new drug molecules that would target novel proteins in the prokaryotic system…”
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Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen–deuterium exchange mass spectrometry by Bagga, Tanaya, Tulsian, Nikhil Kumar, Mok, Yu Keung, Kini, R. Manjunatha, Sivaraman, J.

“…Tripartite motif (TRIM) E3 ligases target specific substrates, including viral proteins, for proteasomal degradation, and are thus essential regulators of the…”
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Inhibition of bacterial cell division protein FtsZ by cinnamaldehyde by Domadia, Prerna, Swarup, Sanjay, Bhunia, Anirban, Sivaraman, J., Dasgupta, Debjani

“…Cinnamaldehyde is a natural product from spices that inhibits cell separation in Bacillus cereus. Cell division is regulated by FtsZ, a prokaryotic homolog of…”
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Unusual quaternary structure of a homodimeric synergistic-type toxin from mamba snake venom defines its molecular evolution by Aoki-Shioi, Narumi, Jobichen, Chacko, Sivaraman, J, Kini, R Manjunatha

“…Snake venoms are complex mixtures of enzymes and nonenzymatic proteins that have evolved to immobilize and kill prey animals or deter predators. Among them,…”
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Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody by Gu, Ying, Tang, Xuhua, Zhang, Xiao, Song, Cuiling, Zheng, Minghua, Wang, Kaihang, Zhang, Jun, Ng, Mun-Hon, Hew, Choy-Leong, Li, Shaowei, Xia, Ningshao, Sivaraman, J.

“…Hepatitis E virus （HEV）, a non-enveloped, positive-sense, single-stranded RNA virus, is a major cause of enteric hepatitis. Classified into the family…”
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Mechanism for Controlling the Dimer-Monomer Switch and Coupling Dimerization to Catalysis of the Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease by Shi, Jiahai, Sivaraman, J, Song, Jianxing

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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