Search Results - "Sivaprakasam, Mangaleswaran"

A Straightforward Synthesis of Enantiopure Bicyclic Azetidines by Sivaprakasam, Mangaleswaran, Couty, François, David, Olivier, Marrot, Jérôme, Sridhar, Regati, Srinivas, Boga, Rama Rao, Kakulapati

“…Enantiomerically pure 1‐azabicyclo[3.2.0]heptane derivatives were synthesized in a straightforward manner from readily available chiral sources, namely,…”
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Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines by Coxon, Christopher R, Anscombe, Elizabeth, Harnor, Suzannah J, Martin, Mathew P, Carbain, Benoit, Golding, Bernard T, Hardcastle, Ian R, Harlow, Lisa K, Korolchuk, Svitlana, Matheson, Christopher J, Newell, David R, Noble, Martin E. M, Sivaprakasam, Mangaleswaran, Tudhope, Susan J, Turner, David M, Wang, Lan Z, Wedge, Stephen R, Wong, Christopher, Griffin, Roger J, Endicott, Jane A, Cano, Céline

“…Purines and related heterocycles substituted at C-2 with 4′-sulfamoylanilino and at C-6 with a variety of groups have been synthesized with the aim of…”
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2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase by Matheson, Christopher J, Coxon, Christopher R, Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M, Hardcastle, Ian R, Harnor, Suzannah J, Mas-Droux, Corine, Newell, David R, Richards, Mark W, Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J, Golding, Bernard T, Cano, Céline

“…Renewed interest in covalent inhibitors of enzymes implicated in disease states has afforded several agents targeted at protein kinases of relevance to…”
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Structure-guided design of purine-based probes for selective Nek2 inhibition by Coxon, Christopher R, Wong, Christopher, Bayliss, Richard, Boxall, Kathy, Carr, Katherine H, Fry, Andrew M, Hardcastle, Ian R, Matheson, Christopher J, Newell, David R, Sivaprakasam, Mangaleswaran, Thomas, Huw, Turner, David, Yeoh, Sharon, Wang, Lan Z, Griffin, Roger J, Golding, Bernard T, Cano, Céline

“…Nek2 (NIMA-related kinase 2) is a cell cycle-dependent serine/threonine protein kinase that regulates centrosome separation at the onset of mitosis…”
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2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase† †Electronic supplementary information (ESI) available: Kinase profiling, assay details, synthetic procedures and characterisation data for all compounds; including aniline precursors. All cell lines were supplied by the American Type Culture Collection, Manassas, Virginia, United States. All animal experiments performed were conducted under a UK Government Home Office License in accordance with relevant n by Matheson, Christopher J., Coxon, Christopher R., Bayliss, Richard, Boxall, Kathy, Carbain, Benoit, Fry, Andrew M., Hardcastle, Ian R., Harnor, Suzannah J., Mas-Droux, Corine, Newell, David R., Richards, Mark W., Sivaprakasam, Mangaleswaran, Turner, David, Griffin, Roger J., Golding, Bernard T., Cano, Céline

“…Renewed interest in covalent inhibitors of enzymes implicated in disease states has afforded several agents targeted at protein kinases of relevance to…”
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Stereocontrolled Synthesis and Pharmacological Evaluation of Azetidine-2,3-Dicarboxylic Acids at NMDA Receptors by Sivaprakasam, Mangaleswaran, Hansen, Kasper B., David, Olivier, Nielsen, Birgitte, Traynelis, Stephen F., Clausen, Rasmus P., Couty, François, Bunch, Lennart

“…The four stereoisomers of azetidine‐2,3‐dicaroxylic acid (L‐trans‐ADC, L‐cis‐ADC, D‐trans‐ADC, and D‐cis‐ADC) were synthesized in a stereocontrolled fashion…”
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A Facile Synthesis of Naturally Occurring Aminopeptidase Inhibitor Tyromycin A by Mangaleswaran, Sivaprakasam, Argade, Narshinha P

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