Search Results - "Sivanesam, Kalkena"

Inhibition of Human Amylin Amyloidogenesis by Human Amylin-Fragment Peptides: Exploring the Effects of Serine Residues and Oligomerization upon Inhibitory Potency by Sivanesam, Kalkena, Andersen, Niels H

“…To date, fragments from within the amyloidogenic-patch region of human amylin (hAM) have been shown to aggregate independently of the full-length peptide. In…”
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MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages by Owen, Allison M, Luan, Liming, Burelbach, Katherine R, McBride, Margaret A, Stothers, Cody L, Boykin, Olivia A, Sivanesam, Kalkena, Schaedel, Jessica F, Patil, Tazeen K, Wang, Jingbin, Hernandez, Antonio, Patil, Naeem K, Sherwood, Edward R, Bohannon, Julia K

“…Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies to protect patients with weak immune responses are…”
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Modulating the Amyloidogenesis of ?-Synuclein by Kalkena Sivanesam, Niels H. Andersen

“…Alpha-Synuclein is found in the neuronal cells but its native function is not well known. While ? -synuclein is an intrinsically disordered protein that adopts…”
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Pre-structured hydrophobic peptide β-strands: A universal amyloid trap? by Sivanesam, Kalkena, Andersen, Niels

“…Amyloid fibril formation has long been studied because of the variety of proteins that are capable of adopting this structure despite sharing little sequence…”
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Hairpin structure stability plays a role in the activity of two antimicrobial peptides by Sivanesam, Kalkena, Kier, Brandon L., Whedon, Samuel D., Chatterjee, Champak, Andersen, Niels H.

“…Many naturally occurring antimicrobial peptides (AMPs) are amphipathic with a β‐hairpin conformation stabilized by cross‐strand disulfides across the…”
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Peptide Inhibitors of the amyloidogenesis of IAPP: verification of the hairpin‐binding geometry hypothesis by Sivanesam, Kalkena, Shu, Irene, Huggins, Kelly N. L., Tatarek‐Nossol, Marianna, Kapurniotu, Aphrodite, Andersen, Niels H.

“…Versions of a previously discovered β‐hairpin peptide inhibitor of IAPP aggregation that are stabilized in that conformation, or even forced to remain in the…”
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Modulating the Amyloidogenesis of α-Synuclein by Sivanesam, Kalkena, Andersen, Niels H

“…Alpha-Synuclein is found in the neuronal cells but its native function is not well known. While α -synuclein is an intrinsically disordered protein that adopts…”
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Fluorescent Probes Reveal a Minimal Ligase Recognition Motif in the Prokaryotic Ubiquitin-like Protein from Mycobacterium tuberculosis by Smirnov, Denis, Dhall, Abhinav, Sivanesam, Kalkena, Sharar, Rudy J, Chatterjee, Champak

“…The prokaryotic ubiquitin-like protein (Pup)-based proteasomal system in the pathogen Mycobacterium tuberculosis (Mtb) is essential for its survival in a…”
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Biological Applications of Designed Hairpin Peptides: As Antimicrobials and as Inhibitors of Amyloidogenesis by Sivanesam, Kalkena

“…More than 40 diseases have been associated with the misfolding of peptides (or proteins) that form fibrils with a very specific morphology. These peptides…”
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Biological consequences of improving the structural stability of hairpins that have antimicrobial activity by Sivanesam, Kalkena, Kier, Brandon L., Whedon, Samuel D., Chatterjee, Champak, Andersen, Niels H.

“…Designing new antimicrobial peptides (AMPs) focuses heavily on the activity of the peptide and less on the elements that stabilize the secondary structure of…”
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Fluorescent probes reveal a minimal ligase recognition motif in the prokaryotic ubiquitin-like protein from Mycobac-terium tuberculosis by Smirnov, Denis, Dhall, Abhinav, Sivanesam, Kalkena, Sharar, Rudy J., Chatterjee, Champak

“…The prokaryotic ubiquitin-like protein (Pup) based proteasomal system in the pathogen Mycobacterium tuberculosis ( Mtb ) is essential for its survival in a…”
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