Search Results - "Siurala, Mikko"

Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity by Santos, João Manuel, Heiniö, Camilla, Cervera-Carrascon, Victor, Quixabeira, Dafne C A, Siurala, Mikko, Havunen, Riikka, Butzow, Ralf, Zafar, Sadia, de Gruijl, Tanja, Lassus, Heini, Kanerva, Anna, Hemminki, Akseli

“…BackgroundOvarian cancers often contain significant numbers of tumor-infiltrating lymphocytes (TILs) that can be readily harnessed for adoptive T-cell therapy…”
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Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy by Havunen, Riikka, Siurala, Mikko, Sorsa, Suvi, Grönberg-Vähä-Koskela, Susanna, Behr, Michael, Tähtinen, Siri, Santos, João Manuel, Karell, Pauliina, Rusanen, Juuso, Nettelbeck, Dirk M., Ehrhardt, Anja, Kanerva, Anna, Hemminki, Akseli

“…Adoptive cell therapy holds much promise in the treatment of cancer but results in solid tumors have been modest. The notable exception is tumor-infiltrating…”
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Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus by Havunen, Riikka, Santos, João M., Sorsa, Suvi, Rantapero, Tommi, Lumen, Dave, Siurala, Mikko, Airaksinen, Anu J., Cervera-Carrascon, Victor, Tähtinen, Siri, Kanerva, Anna, Hemminki, Akseli

“…Cancer treatment with local administration of armed oncolytic viruses could potentially induce systemic antitumor effects, or the abscopal effect, as they…”
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Cytokine-Coding Oncolytic Adenovirus TILT-123 Is Safe, Selective, and Effective as a Single Agent and in Combination with Immune Checkpoint Inhibitor Anti-PD-1 by Havunen, Riikka, Kalliokoski, Riikka, Siurala, Mikko, Sorsa, Suvi, Santos, João M, Cervera-Carrascon, Victor, Anttila, Marjukka, Hemminki, Akseli

“…Oncolytic viruses provide a biologically multi-faceted treatment option for patients who cannot be cured with currently available treatment options. We…”
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CD40L coding oncolytic adenovirus allows long-term survival of humanized mice receiving dendritic cell therapy by Zafar, Sadia, Sorsa, Suvi, Siurala, Mikko, Hemminki, Otto, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, João Manuel, Wang, Hongjie, Lieber, Andre, De Gruijl, Tanja, Kanerva, Anna, Hemminki, Akseli

“…Dendritic cells (DCs) are crucial players in promoting immune responses. Logically, adoptive DC therapy is a promising approach in cancer immunotherapy. One of…”
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238 Potentiating CAR T cell therapy through synthetic IL-9R signaling by Castelli, Sofia, Uslu, Ugur, Finck, Amanda, Da, Tong, Assenmacher, Charles-Antoine, Siurala, Mikko, Young, Regina M, June, Carl H

“…BackgroundChimeric antigen receptor (CAR) T cell therapy has shown limited success in treating solid tumors. One approach for improving antitumor efficacy in…”
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Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition by Cervera-Carrascon, Victor, Quixabeira, Dafne C.A., Santos, Joao Manuel, Havunen, Riikka, Zafar, Sadia, Hemminki, Otto, Heiniö, Camilla, Munaro, Eleonora, Siurala, Mikko, Sorsa, Suvi, Mirtti, Tuomas, Järvinen, Petrus, Mildh, Markus, Nisen, Harry, Rannikko, Antti, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli

“…Checkpoint inhibitors have revolutionized cancer therapy and validated immunotherapy as an approach. Unfortunately, responses are seen in a minority of…”
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Comparison of Clinically Relevant Oncolytic Virus Platforms for Enhancing T Cell Therapy of Solid Tumors by Cervera-Carrascon, Victor, Quixabeira, Dafne C.A., Havunen, Riikka, Santos, Joao M., Kutvonen, Emma, Clubb, James H.A., Siurala, Mikko, Heiniö, Camilla, Zafar, Sadia, Koivula, Teija, Lumen, Dave, Vaha, Marjo, Garcia-Horsman, Arturo, Airaksinen, Anu J., Sorsa, Suvi, Anttila, Marjukka, Hukkanen, Veijo, Kanerva, Anna, Hemminki, Akseli

“…Despite some promising results, the majority of patients do not benefit from T cell therapies, as tumors prevent T cells from entering the tumor, shut down…”
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Intravenously usable fully serotype 3 oncolytic adenovirus coding for CD40L as an enabler of dendritic cell therapy by Zafar, Sadia, Parviainen, Suvi, Siurala, Mikko, Hemminki, Otto, Havunen, Riikka, Tähtinen, Siri, Bramante, Simona, Vassilev, Lotta, Wang, Hongjie, Lieber, Andre, Hemmi, Silvio, de Gruijl, Tanja, Kanerva, Anna, Hemminki, Akseli

“…Vaccination with dendritic cells (DCs), the most potent professional antigen-presenting cells in the body, is a promising approach in cancer immunotherapy…”
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Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy by Santos, João Manuel, Cervera-Carrascon, Víctor, Havunen, Riikka, Zafar, Sadia, Siurala, Mikko, Sorsa, Suvi, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli

“…Lymphodepleting preconditioning with high-dose chemotherapy is commonly used to increase the clinical efficacy of adoptive T cell therapy (ACT) strategies,…”
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Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses by Watanabe, Keisuke, Luo, Yanping, Da, Tong, Guedan, Sonia, Ruella, Marco, Scholler, John, Keith, Brian, Young, Regina M, Engels, Boris, Sorsa, Suvi, Siurala, Mikko, Havunen, Riikka, Tähtinen, Siri, Hemminki, Akseli, June, Carl H

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by its highly immunosuppressive tumor microenvironment (TME) that limits T cell infiltration and…”
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Potentiating adoptive cell therapy using synthetic IL-9 receptors by Kalbasi, Anusha, Siurala, Mikko, Su, Leon L., Tariveranmoshabad, Mito, Picton, Lora K., Ravikumar, Pranali, Li, Peng, Lin, Jian-Xin, Escuin-Ordinas, Helena, Da, Tong, Kremer, Sarah V., Sun, Amy L., Castelli, Sofia, Agarwal, Sangya, Scholler, John, Song, Decheng, Rommel, Philipp C., Radaelli, Enrico, Young, Regina M., Leonard, Warren J., Ribas, Antoni, June, Carl H., Garcia, K. Christopher

“…Synthetic receptor signalling has the potential to endow adoptively transferred T cells with new functions that overcome major barriers in the treatment of…”
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Oncolytic adenovirus and doxorubicin‐based chemotherapy results in synergistic antitumor activity against soft‐tissue sarcoma by Siurala, Mikko, Bramante, Simona, Vassilev, Lotta, Hirvinen, Mari, Parviainen, Suvi, Tähtinen, Siri, Guse, Kilian, Cerullo, Vincenzo, Kanerva, Anna, Kipar, Anja, Vähä‐Koskela, Markus, Hemminki, Akseli

“…Despite originating from several different tissues, soft‐tissue sarcomas (STS) are often grouped together as they share mesenchymal origin and treatment…”
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Adenoviral production of interleukin-2 at the tumor site removes the need for systemic postconditioning in adoptive cell therapy by Santos, Joao Manuel, Havunen, Riikka, Siurala, Mikko, Cervera-Carrascon, Víctor, Tähtinen, Siri, Sorsa, Suvi, Anttila, Marjukka, Karell, Pauliina, Kanerva, Anna, Hemminki, Akseli

“…Systemic high dose interleukin-2 (IL-2) postconditioning has long been utilized in boosting the efficacy of T cells in adoptive cell therapy (ACT) of solid…”
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Adenoviral Delivery of Tumor Necrosis Factor-α and Interleukin-2 Enables Successful Adoptive Cell Therapy of Immunosuppressive Melanoma by Siurala, Mikko, Havunen, Riikka, Saha, Dipongkor, Lumen, Dave, Airaksinen, Anu J., Tähtinen, Siri, Cervera-Carrascon, Víctor, Bramante, Simona, Parviainen, Suvi, Vähä-Koskela, Markus, Kanerva, Anna, Hemminki, Akseli

“…Adoptive T-cell transfer is a promising treatment approach for metastatic cancer, but efficacy in solid tumors has only been achieved with toxic pre- and…”
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GMCSF‐armed vaccinia virus induces an antitumor immune response by Parviainen, Suvi, Ahonen, Marko, Diaconu, Iulia, Kipar, Anja, Siurala, Mikko, Vähä‐Koskela, Markus, Kanerva, Anna, Cerullo, Vincenzo, Hemminki, Akseli

“…Oncolytic Western Reserve strain vaccinia virus selective for epidermal growth factor receptor pathway mutations and tumor‐associated hypermetabolism was armed…”
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T-Cell Therapy Enabling Adenoviruses Coding for IL2 and TNFα Induce Systemic Immunomodulation in Mice With Spontaneous Melanoma by Tähtinen, Siri, Blattner, Carolin, Vähä-Koskela, Markus, Saha, Dipongkor, Siurala, Mikko, Parviainen, Suvi, Utikal, Jochen, Kanerva, Anna, Umansky, Viktor, Hemminki, Akseli

“…The immunosuppressive microenvironment of solid tumors renders adoptively transferred T cells hypofunctional. However, adenoviral delivery of immunostimulatory…”
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Publisher Correction: Potentiating adoptive cell therapy using synthetic IL-9 receptors by Kalbasi, Anusha, Siurala, Mikko, Su, Leon L., Tariveranmoshabad, Mito, Picton, Lora K., Ravikumar, Pranali, Li, Peng, Lin, Jian-Xin, Escuin-Ordinas, Helena, Da, Tong, Kremer, Sarah V., Sun, Amy L., Castelli, Sofia, Agarwal, Sangya, Scholler, John, Song, Decheng, Rommel, Philipp C., Radaelli, Enrico, Young, Regina M., Leonard, Warren J., Ribas, Antoni, June, Carl H., Garcia, K. Christopher

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Effect of Genetic Modifications on Physical and Functional Titers of Adenoviral Cancer Gene Therapy Constructs by Heiniö, Camilla, Sorsa, Suvi, Siurala, Mikko, Grönberg-Vähä-Koskela, Susanna, Havunen, Riikka, Haavisto, Elina, Koski, Anniina, Hemminki, Otto, Zafar, Sadia, Cervera-Carrascon, Víctor, Munaro, Eleonora, Kanerva, Anna, Hemminki, Akseli

“…After the discovery and characterization of the adenovirus in the 1950s, this prevalent cause of the common cold and other usually mild diseases has been…”
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652. Culture and Characterization of Tumor-Infiltrating Lymphocytes of the Syrian Hamster by Siurala, Mikko, Vähä-Koskela, Markus, Havunen, Riikka, Tähtinen, Siri, Bramante, Simona, Parviainen, Suvi, Hemminki, Akseli

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