Search Results - "Siu, Stacey"

R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm by Shide, Kotaro, Kameda, Takuro, Markovtsov, Vadim, Shimoda, Haruko K., Tonkin, Elizabeth, Fang, Shuling, Liu, Chian, Gelman, Marina, Lang, Wayne, Romero, Jason, McLaughlin, John, Bhamidipati, Somasekhar, Clough, Jeffrey, Low, Caroline, Reitsma, Andrea, Siu, Stacey, Pine, Polly, Park, Gary, Torneros, Allan, Duan, Matt, Singh, Rajinder, Payan, Donald G., Matsunaga, Takuya, Hitoshi, Yasumichi, Shimoda, Kazuya

“…The activating mutations in JAK2 (including JAK2V617F) that have been described in patients with myeloproliferative neoplasms (MPNs) are linked directly to MPN…”
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Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma by Nilsson, Magnus, Rhedin, Magdalena, Hendrickx, Ramon, Berglund, Susanne, Piras, Antonio, Blomgran, Parmis, Cavallin, Anders, Collins, Mia, Dahl, Goran, Dekkak, Bilel, Ericsson, Therese, Hagberg, Niklas, Holmberg, Ann Aurell, Leffer, Agnes, Lundqvist, Anders J, Markou, Thomais, Pinkerton, James, Ronnblom, Lars, Siu, Stacey, Taylor, Vanessa, Wennberg, Tiiu, Zervas, Dimitrios, Laurence, Arian D.J, Mitra, Suman, Belvisi, Maria G, Birrell, Mark, Borde, Annika

“…Purpose: Janus kinase 1 (JAK1) is implicated in multiple infammatory pathways that are critical for the pathogenesis of asthma, including the interleukin…”
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Abstract 346: Potential role for R191, potent and selective IRAK4 kinase inhibitor, in treatment of hematologic malignancies by Markovtsov, Vadim V., Lamagna, Chrystelle, Chan, Meagan, Yi, Sothy, Young, Chi, Frances, Roy, Siu, Stacey, Braselmann, Sylvia, Li, Hui, Singh, Rajinder, Park, Gary, Masuda, Esteban, Taylor, Vanessa, Payan, Donald G.

“…Abstract Recent advances in genome sequencing and tumor proteome and transcriptome analysis uncovered a key role for MyD88-dependent Toll-Like Receptor (TLR)…”
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Abstract 4869: Small molecule inhibitors of the anti-inflammatory TAM receptor MerTK by Holland, Sacha J., Owyang, Alex M., Yi, Sothy, Young, Chi, Braselmann, Sylvia, Frances, Roy, Bagos, Arthur, Tai, Ernest, Siu, Stacey, Park, Gary, Lau, David, Duan, Matt, Kolluri, Rao, Bhamidipati, Somasekhar, Darwish, Ihab, Duncton, Matthew, Singh, Rajinder, Masuda, Esteban, Payan, Donald G.

“…Abstract Introduction: MerTK, a TAM (Tyro3, Axl, MerTK) family RTK, is expressed on phagocytic myeloid and epithelial cells. Its normal function is to dampen…”
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Characterization of a small molecule IRAK4 kinase inhibitor for the treatment of autoimmune and inflammatory diseases by Lamagna, Chrystelle, Chan, Meagan, Yi, Sothy, Young, Chi, Frances, Roy, Siu, Stacey, Braselmann, Sylvia, Payan, Donald G, McMurtrie, Darren, Kelley, Ryan, Heckrodt, Thilo, Yen, Rose, Chen, Yan, Li, Hui, Singh, Rajinder, Park, Gary, Masuda, Esteban, Taylor, Vanessa

“…Abstract IRAK4 is a key protein kinase in immune cells. It is responsible for initiating MyD88-dependent signaling from most Toll-Like Receptors (TLR) and…”
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In vitro and in vivo characterization of small molecule inhibitors of the anti-inflammatory TAM receptor MerTK by Owyang, Alexander, Holland, Sacha, Yi, Sothy, Young, Chi, Braselmann, Sylvia, Frances, Roy, Bagos, Art, Tai, Ernie, Siu, Stacey, Park, Gary, Lau, David, Duan, Matt, Yu, Jiaxin, Ding, Pingyu, Kolluri, Rao, Bhamidipati, Somasekhar, Darwish, Ihab, Singh, Raj, Payan, Donald G, Masuda, Esteban S

“…Abstract MerTK, a TAM (Tyro3, Axl, MerTK) family RTK, is expressed on phagocytic cells. Its normal function is to dampen innate immune responses to…”
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In Vitro and in Vivo Inhibition of JAK2 Signaling by Potent and Selective JAK2 Inhibitor by Markovtsov, Vadim, Tonkin, Elizabeth, Fang, Shuling, Liu, Chiang, Gelman, Marina, Lang, Wayne, Romero, Jason, McLaughlin, John, Bhamidipati, Somasekhar, Clough, Jeffrey, Singh, Rajinder, Low, Caroline, Reitsma, Andrea, Taylor, Vanessa, Siu, Stacey, Park, Gary, Sweeney, David, Pine, Polly, Torneros, Allan, Clemens, George, Duan, Matt, Daniel, Ruby, Payan, Donald, Holland, Sacha, Hitoshi, Yasumichi

“…Recent advances in understanding the role of JAK2 V617F mutation in Bcr-Abl negative myeloproliferative (MPD) diseases pathogenesis opened up a possibility to…”
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