Search Results - "Siu, Karen K."

The cell biology of fertilization: Gamete attachment and fusion by Siu, Karen K, Serrão, Vitor Hugo B, Ziyyat, Ahmed, Lee, Jeffrey E

“…Fertilization is defined as the union of two gametes. During fertilization, sperm and egg fuse to form a diploid zygote to initiate prenatal development. In…”
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Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F by Siu, Karen K., Sultana, Azmiri, Azimi, Farshad C., Lee, Jeffrey E.

“…The human APOBEC3 family of DNA cytosine deaminases serves as a front-line intrinsic immune response to inhibit the replication of diverse retroviruses…”
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Identification of RSV Fusion Protein Interaction Domains on the Virus Receptor, Nucleolin by Mastrangelo, Peter, Chin, Allysia A, Tan, Stephanie, Jeon, Amy H, Ackerley, Cameron A, Siu, Karen K, Lee, Jeffrey E, Hegele, Richard G

“…Nucleolin is an essential cellular receptor to human respiratory syncytial virus (RSV). Pharmacological targeting of the nucleolin RNA binding domain RBD1,2…”
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Altered Lung Motion is a Sensitive Indicator of Regional Lung Disease by Fouras, Andreas, Allison, Beth J., Kitchen, Marcus J., Dubsky, Stephen, Nguyen, Jayne, Hourigan, Kerry, Siu, Karen K. W., Lewis, Rob A., Wallace, Megan J., Hooper, Stuart B.

“…Since lung diseases adversely affect airflow during breathing, they must also alter normal lung motion, which can be exploited to detect these diseases…”
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Biotin Synthase Exhibits Burst Kinetics and Multiple Turnovers in the Absence of Inhibition by Products and Product-Related Biomolecules by Farrar, Christine E, Siu, Karen K. W, Howell, P. Lynne, Jarrett, Joseph T

“…Biotin synthase (BS) is a member of the “SAM radical” superfamily of enzymes, which catalyze reactions in which the reversible or irreversible oxidation of…”
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Inspiration regulates the rate and temporal pattern of lung liquid clearance and lung aeration at birth by Siew, Melissa L, Wallace, Megan J, Kitchen, Marcus J, Lewis, Robert A, Fouras, Andreas, te Pas, Arjan B, Yagi, Naoto, Uesugi, Kentaro, Siu, Karen K. W, Hooper, Stuart B

“…1 Department of Physiology, 2 School of Physics, 3 Monash Centre for Synchrotron Science, and 4 Department of Biological Engineering, Monash University,…”
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In Vivo X-Ray Imaging Reveals Improved Airway Surface Hydration after a Therapy Designed for Cystic Fibrosis by MORGAN, Kaye S, DONNELLEY, Martin, FOURAS, Andreas, YAGI, Naoto, SUZUKI, Yoshio, TAKEUCHI, Akihisa, UESUGI, Kentaro, BOUCHER, Richard C, SIU, Karen K. W, PARSONS, David W

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Quantitative x-ray phase-contrast imaging using a single grating of comparable pitch to sample feature size by Morgan, Kaye S, Paganin, David M, Siu, Karen K W

“…The ability to quantitatively retrieve transverse phase maps during imaging by using coherent x rays often requires a precise grating or analyzer-crystal-based…”
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Synchrotron-based dynamic computed tomography of tissue motion for regional lung function measurement by Dubsky, Stephen, Hooper, Stuart B., Siu, Karen K. W., Fouras, Andreas

“…During breathing, lung inflation is a dynamic process involving a balance of mechanical factors, including trans-pulmonary pressure gradients, tissue…”
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LRIG1 controls proliferation of adult neural stem cells by facilitating TGFβ and BMP signalling pathways by Ouzikov, Stephanie, Edwards, Kyshona M., Anandampillai, Tanvi, Watanabe, Samuel, Lozano Casasbuenas, Daniela, Siu, Karen K., Harkins, Danyon, Dou, Aaron, Jeong, Danielle, Lee, Jeffrey E., Yuzwa, Scott A.

“…Adult Neural Stem Cells (aNSCs) in the ventricular-subventricular zone (V-SVZ) are largely quiescent. Here, we characterize the mechanism underlying the…”
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X-ray Velocimetry and Haemodynamic Forces Within a Stenosed Femoral Model at Physiological Flow Rates by Jamison, R. Aidan, Dubsky, Stephen, Siu, Karen K. W., Hourigan, Kerry, Fouras, Andreas

“…High resolution in vivo velocity measurements within the cardiovascular system are essential for accurate calculation of vessel wall shear stress, a highly…”
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Measuring airway surface liquid depth in ex vivo mouse airways by x-ray imaging for the assessment of cystic fibrosis airway therapies by Morgan, Kaye S, Donnelley, Martin, Paganin, David M, Fouras, Andreas, Yagi, Naoto, Suzuki, Yoshio, Takeuchi, Akihisa, Uesugi, Kentaro, Boucher, Richard C, Parsons, David W, Siu, Karen K W

“…In the airways of those with cystic fibrosis (CF), the leading pathophysiological hypothesis is that an ion channel defect results in a relative decrease in…”
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Variability of in vivo fluid dose distribution in mouse airways is visualized by high-speed synchrotron X-ray imaging by Donnelley, Martin, Morgan, Kaye S, Siu, Karen K W, Parsons, David W

“…The manner in which fluid instillations into mouse nose and lung distribute through the airways is poorly understood. Many agents are delivered in this way for…”
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Phase contrast imaging reveals low lung volumes and surface areas in the developing marsupial by Simpson, Shannon J, Siu, Karen K W, Yagi, Naoto, Whitley, Jane C, Lewis, Robert A, Frappell, Peter B

“…Marsupials are born with immature lungs when compared to eutherian mammals and rely, to various extents, on cutaneous gas exchange in order to meet metabolic…”
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IMAGING LUNG AERATION AND LUNG LIQUID CLEARANCE AT BIRTH USING PHASE CONTRAST X-RAY IMAGING by Hooper, Stuart B, Kitchen, Marcus J, Siew, Melissa LL, Lewis, Robert A, Fouras, Andreas, B te Pas, Arjan, Siu, Karen KW, Yagi, Naoto, Uesugi, Kentaro, Wallace, Megan J

“…SUMMARY 1 The transition to extra‐uterine life at birth is critically dependent on airway liquid clearance to allow the entry of air and the onset of gaseous…”
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Tracking extended mucociliary transport activity of individual deposited particles: longitudinal synchrotron X-ray imaging in live mice by Donnelley, Martin, Morgan, Kaye S., Siu, Karen K. W., Fouras, Andreas, Farrow, Nigel R., Carnibella, Richard P., Parsons, David W.

“…To assess potential therapies for respiratory diseases in which mucociliary transit (MCT) is impaired, such as cystic fibrosis and primary ciliary dyskinesia,…”
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Imaging lung aeration and lung liquid clearance at birth by Hooper, Stuart B, Kitchen, Marcus J, Wallace, Megan J, Yagi, Naoto, Uesugi, Kentaro, Morgan, Michael J, Hall, Chris, Siu, Karen K.W, Williams, Ivan M, Siew, Melissa, Irvine, Sarah C, Pavlov, Konstantin, Lewis, Robert A

“…Aeration of the lung and the transition to air-breathing at birth is fundamental to mammalian life and initiates major changes in cardiopulmonary physiology…”
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High‐resolution visualization of airspace structures in intact mice via synchrotron phase‐contrast X‐ray imaging (PCXI) by Parsons, David W., Morgan, Kaye, Donnelley, Martin, Fouras, Andreas, Crosbie, Jeffrey, Williams, Ivan, Boucher, Richard C., Uesugi, Kentaro, Yagi, Naoto, Siu, Karen K. W.

“…Anatomical visualization of airspace‐containing organs in intact small animals has been limited by the resolution and contrast available from current imaging…”
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Quantitative single-exposure x-ray phase contrast imaging using a single attenuation grid by Morgan, Kaye S, Paganin, David M, Siu, Karen K W

“…A single-exposure quantitative method of x-ray phase contrast imaging, suitable for animal in vivo observations, is described and shown experimentally both for…”
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Dry deposition of pollutant and marker particles onto live mouse airway surfaces enhances monitoring of individual particle mucociliary transit behaviour by Donnelley, Martin, Morgan, Kaye S., Siu, Karen K. W., Parsons, David W.

“…Particles suspended in the air are inhaled during normal respiration and unless cleared by airway defences, such as the mucociliary transit (MCT) system, they…”
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