Search Results - "Siu, Karen K W"

Biotin Synthase Exhibits Burst Kinetics and Multiple Turnovers in the Absence of Inhibition by Products and Product-Related Biomolecules by Farrar, Christine E, Siu, Karen K. W, Howell, P. Lynne, Jarrett, Joseph T

“…Biotin synthase (BS) is a member of the “SAM radical” superfamily of enzymes, which catalyze reactions in which the reversible or irreversible oxidation of…”
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Altered Lung Motion is a Sensitive Indicator of Regional Lung Disease by Fouras, Andreas, Allison, Beth J., Kitchen, Marcus J., Dubsky, Stephen, Nguyen, Jayne, Hourigan, Kerry, Siu, Karen K. W., Lewis, Rob A., Wallace, Megan J., Hooper, Stuart B.

“…Since lung diseases adversely affect airflow during breathing, they must also alter normal lung motion, which can be exploited to detect these diseases…”
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Measuring airway surface liquid depth in ex vivo mouse airways by x-ray imaging for the assessment of cystic fibrosis airway therapies by Morgan, Kaye S, Donnelley, Martin, Paganin, David M, Fouras, Andreas, Yagi, Naoto, Suzuki, Yoshio, Takeuchi, Akihisa, Uesugi, Kentaro, Boucher, Richard C, Parsons, David W, Siu, Karen K W

“…In the airways of those with cystic fibrosis (CF), the leading pathophysiological hypothesis is that an ion channel defect results in a relative decrease in…”
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X-ray Velocimetry and Haemodynamic Forces Within a Stenosed Femoral Model at Physiological Flow Rates by Jamison, R. Aidan, Dubsky, Stephen, Siu, Karen K. W., Hourigan, Kerry, Fouras, Andreas

“…High resolution in vivo velocity measurements within the cardiovascular system are essential for accurate calculation of vessel wall shear stress, a highly…”
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Phase contrast imaging reveals low lung volumes and surface areas in the developing marsupial by Simpson, Shannon J, Siu, Karen K W, Yagi, Naoto, Whitley, Jane C, Lewis, Robert A, Frappell, Peter B

“…Marsupials are born with immature lungs when compared to eutherian mammals and rely, to various extents, on cutaneous gas exchange in order to meet metabolic…”
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Variability of in vivo fluid dose distribution in mouse airways is visualized by high-speed synchrotron X-ray imaging by Donnelley, Martin, Morgan, Kaye S, Siu, Karen K W, Parsons, David W

“…The manner in which fluid instillations into mouse nose and lung distribute through the airways is poorly understood. Many agents are delivered in this way for…”
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Synchrotron-based dynamic computed tomography of tissue motion for regional lung function measurement by Dubsky, Stephen, Hooper, Stuart B., Siu, Karen K. W., Fouras, Andreas

“…During breathing, lung inflation is a dynamic process involving a balance of mechanical factors, including trans-pulmonary pressure gradients, tissue…”
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IMAGING LUNG AERATION AND LUNG LIQUID CLEARANCE AT BIRTH USING PHASE CONTRAST X-RAY IMAGING by Hooper, Stuart B, Kitchen, Marcus J, Siew, Melissa LL, Lewis, Robert A, Fouras, Andreas, B te Pas, Arjan, Siu, Karen KW, Yagi, Naoto, Uesugi, Kentaro, Wallace, Megan J

“…SUMMARY 1 The transition to extra‐uterine life at birth is critically dependent on airway liquid clearance to allow the entry of air and the onset of gaseous…”
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Inspiration regulates the rate and temporal pattern of lung liquid clearance and lung aeration at birth by Siew, Melissa L, Wallace, Megan J, Kitchen, Marcus J, Lewis, Robert A, Fouras, Andreas, te Pas, Arjan B, Yagi, Naoto, Uesugi, Kentaro, Siu, Karen K. W, Hooper, Stuart B

“…1 Department of Physiology, 2 School of Physics, 3 Monash Centre for Synchrotron Science, and 4 Department of Biological Engineering, Monash University,…”
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In Vivo X-Ray Imaging Reveals Improved Airway Surface Hydration after a Therapy Designed for Cystic Fibrosis by MORGAN, Kaye S, DONNELLEY, Martin, FOURAS, Andreas, YAGI, Naoto, SUZUKI, Yoshio, TAKEUCHI, Akihisa, UESUGI, Kentaro, BOUCHER, Richard C, SIU, Karen K. W, PARSONS, David W

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Quantitative x-ray phase-contrast imaging using a single grating of comparable pitch to sample feature size by Morgan, Kaye S, Paganin, David M, Siu, Karen K W

“…The ability to quantitatively retrieve transverse phase maps during imaging by using coherent x rays often requires a precise grating or analyzer-crystal-based…”
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High‐resolution visualization of airspace structures in intact mice via synchrotron phase‐contrast X‐ray imaging (PCXI) by Parsons, David W., Morgan, Kaye, Donnelley, Martin, Fouras, Andreas, Crosbie, Jeffrey, Williams, Ivan, Boucher, Richard C., Uesugi, Kentaro, Yagi, Naoto, Siu, Karen K. W.

“…Anatomical visualization of airspace‐containing organs in intact small animals has been limited by the resolution and contrast available from current imaging…”
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Tracking extended mucociliary transport activity of individual deposited particles: longitudinal synchrotron X-ray imaging in live mice by Donnelley, Martin, Morgan, Kaye S., Siu, Karen K. W., Fouras, Andreas, Farrow, Nigel R., Carnibella, Richard P., Parsons, David W.

“…To assess potential therapies for respiratory diseases in which mucociliary transit (MCT) is impaired, such as cystic fibrosis and primary ciliary dyskinesia,…”
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Imaging lung aeration and lung liquid clearance at birth by Hooper, Stuart B, Kitchen, Marcus J, Wallace, Megan J, Yagi, Naoto, Uesugi, Kentaro, Morgan, Michael J, Hall, Chris, Siu, Karen K.W, Williams, Ivan M, Siew, Melissa, Irvine, Sarah C, Pavlov, Konstantin, Lewis, Robert A

“…Aeration of the lung and the transition to air-breathing at birth is fundamental to mammalian life and initiates major changes in cardiopulmonary physiology…”
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Dry deposition of pollutant and marker particles onto live mouse airway surfaces enhances monitoring of individual particle mucociliary transit behaviour by Donnelley, Martin, Morgan, Kaye S., Siu, Karen K. W., Parsons, David W.

“…Particles suspended in the air are inhaled during normal respiration and unless cleared by airway defences, such as the mucociliary transit (MCT) system, they…”
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Testing microstructural adaptation in the earliest dental tools by Jones, David, Evans, Alistair R., Rayfield, Emily J., Siu, Karen K. W., Donoghue, Philip C. J.

“…Conodont elements are the earliest vertebrate dental structures. The dental tools on elements responsible for food fracture—cusps and denticles—are usually…”
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Quantitative single-exposure x-ray phase contrast imaging using a single attenuation grid by Morgan, Kaye S, Paganin, David M, Siu, Karen K W

“…A single-exposure quantitative method of x-ray phase contrast imaging, suitable for animal in vivo observations, is described and shown experimentally both for…”
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The projection approximation versus an exact solution for X-ray phase contrast imaging, with a plane wave scattered by a dielectric cylinder by Morgan, Kaye S., Siu, Karen K.W., Paganin, David M.

“…We show that exact solutions for an X-ray plane wave scattered by a dielectric cylinder with radius large compared to the radiation wavelength, give almost the…”
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A new technique to examine individual pollutant particle and fibre deposition and transit behaviour in live mouse trachea by Donnelley, Martin, Siu, Karen K. W., Morgan, Kaye S., Skinner, William, Suzuki, Yoshio, Takeuchi, Akihisa, Uesugi, Kentaro, Yagi, Naoto, Parsons, David W.

“…During respiration, particles suspended in the air are inhaled and unless cleared by airway defences they can remain and affect lung health. Their size…”
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Quantification of heterogeneity in lung disease with image-based pulmonary function testing by Stahr, Charlene S., Samarage, Chaminda R., Donnelley, Martin, Farrow, Nigel, Morgan, Kaye S., Zosky, Graeme, Boucher, Richard C., Siu, Karen K. W., Mall, Marcus A., Parsons, David W., Dubsky, Stephen, Fouras, Andreas

“…Computed tomography (CT) and spirometry are the mainstays of clinical pulmonary assessment. Spirometry is effort dependent and only provides a single global…”
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