Search Results - "Siu, Jerry"

Impact of Head and Neck Cancer Treatment on Survivors' Mealtime Experience by Chan, Karen M. K., Chan, Herman K. W., Siu, Jerry Y. L., Pu, Dai, Nund, Rebecca L., Ward, Elizabeth C.

“…Objectives/Hypothesis The objectives of the study were to develop a mealtime experience self‐assessment questionnaire that was head and neck cancer (HNC)…”
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Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS by Saha, Ashis K, Yu, Xiang, Lin, Jian, Lobera, Mercedes, Sharadendu, Anurag, Chereku, Srinivas, Schutz, Nili, Segal, Dalia, Marantz, Yael, McCauley, Dilara, Middleton, Scot, Siu, Jerry, Bürli, Roland W, Buys, Janet, Horner, Michelle, Salyers, Kevin, Schrag, Michael, Vargas, Hugo M, Xu, Yang, McElvain, Michele, Xu, Han

“…We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity. 1-((4-(5-Benzylbenzofuran-2-yl)-3-fluorophenyl)methyl)…”
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Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5 by Cee, Victor J, Frohn, Mike, Lanman, Brian A, Golden, Jennifer, Muller, Kristine, Neira, Susana, Pickrell, Alex, Arnett, Heather, Buys, Janet, Gore, Anu, Fiorino, Mike, Horner, Michelle, Itano, Andrea, Lee, Matt R, McElvain, Michele, Middleton, Scot, Schrag, Michael, Rivenzon-Segal, Dalia, Vargas, Hugo M, Xu, Han, Xu, Yang, Zhang, Xuxia, Siu, Jerry, Wong, Min, Bürli, Roland W

“…The optimization of a series of thiazolopyridine S1P1 agonists with limited activity at the S1P3 receptor is reported. These efforts resulted in the discovery…”
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B7RP-1-ICOS Interactions Are Required for Optimal Infection-Induced Expansion of CD4+ Th1 and Th2 Responses by Wilson, Emma H, Zaph, Colby, Mohrs, Markus, Welcher, Andy, Siu, Jerry, Artis, David, Hunter, Christopher A

“…Although initial reports linked the costimulatory molecule ICOS preferentially with the development of Th2 cells, there is evidence that it is not required for…”
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Predictability of peripheral lymphocyte reduction of novel S1P1 agonists by in vitro GPCR signaling profile by Xu, Han, McElvain, Michele, Fiorino, Mike, Henkle, Brad, Sherman, Lisa, Xu, Yang, Tominey, Elizabeth, Kelley, Keith, Adlam, Matt, Bürli, Roland, Siu, Jerry, Wong, Min, Cee, Victor J

“…Surrogate readouts of G-protein-coupled receptor signaling pathways using highly engineered systems are often employed in the drug discovery process. However,…”
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Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: Potent S1P1 agonists with in vivo lymphocyte-depleting activity by Frohn, Mike, Cee, Victor J., Lanman, Brian A., Pickrell, Alexander J., Golden, Jennifer, Rivenzon-Segal, Dalia, Middleton, Scot, Fiorino, Mike, Xu, Han, Schrag, Michael, Xu, Yang, McElvain, Michele, Muller, Kristine, Siu, Jerry, Bürli, Roland

“…An SAR campaign designed to increase polarity in the ‘tail’ region of benzothiazole 1 resulted in two series of structurally novel 5-and 6-substituted S1P1…”
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B7RP-1-ICOS Interactions Are Required for Optimal Infection-Induced Expansion of CD4+ Th1 and Th2 Responses1 by Wilson, Emma H., Zaph, Colby, Mohrs, Markus, Welcher, Andy, Siu, Jerry, Artis, David, Hunter, Christopher A.

“…Although initial reports linked the costimulatory molecule ICOS preferentially with the deelopment of Th2 cells, there is evidence that it is not required for…”
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B7RP-1-ICOS Interactions Are Required for Optimal Infection-Induced Expansion of CD4 super(+) Th1 and Th2 Responses by Wilson, Emma H, Zaph, Colby, Mohrs, Markus, Welcher, Andy, Siu, Jerry, Artis, David, Hunter, Christopher A

“…Although initial reports linked the costimulatory molecule ICOS preferentially with the development of Th2 cells, there is evidence that it is not required for…”
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Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1) by Lanman, Brian A, Cee, Victor J, Cheruku, Srinivasa R, Frohn, Mike, Golden, Jennifer, Lin, Jian, Lobera, Mercedes, Marantz, Yael, Muller, Kristine M, Neira, Susana C, Pickrell, Alexander J, Rivenzon-Segal, Dalia, Schutz, Nili, Sharadendu, Anurag, Yu, Xiang, Zhang, Zhaoda, Buys, Janet, Fiorino, Mike, Gore, Anu, Horner, Michelle, Itano, Andrea, McElvain, Michele, Middleton, Scot, Schrag, Michael, Vargas, Hugo M, Xu, Han, Xu, Yang, Zhang, Xuxia, Siu, Jerry, Bürli, Roland W

“…Optimization of a benzofuranyl S1P1 agonist lead compound (3) led to the discovery of…”
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Discovery of AMG 369, a Thiazolo[5,4- b ]pyridine Agonist of S1P 1 and S1P 5 by Cee, Victor J., Frohn, Mike, Lanman, Brian A., Golden, Jennifer, Muller, Kristine, Neira, Susana, Pickrell, Alex, Arnett, Heather, Buys, Janet, Gore, Anu, Fiorino, Mike, Horner, Michelle, Itano, Andrea, Lee, Matt R., McElvain, Michele, Middleton, Scot, Schrag, Michael, Rivenzon-Segal, Dalia, Vargas, Hugo M., Xu, Han, Xu, Yang, Zhang, Xuxia, Siu, Jerry, Wong, Min, Bürli, Roland W.

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Benzofuran Derivatives as Potent, Orally Active S1P 1 Receptor Agonists: A Preclinical Lead Molecule for MS by Saha, Ashis K., Yu, Xiang, Lin, Jian, Lobera, Mercedes, Sharadendu, Anurag, Chereku, Srinivas, Schutz, Nili, Segal, Dalia, Marantz, Yael, McCauley, Dilara, Middleton, Scot, Siu, Jerry, Bürli, Roland W., Buys, Janet, Horner, Michelle, Salyers, Kevin, Schrag, Michael, Vargas, Hugo M., Xu, Yang, McElvain, Michele, Xu, Han

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Discovery of a Potent, S1P 3 -Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P 1 ) by Lanman, Brian A., Cee, Victor J., Cheruku, Srinivasa R., Frohn, Mike, Golden, Jennifer, Lin, Jian, Lobera, Mercedes, Marantz, Yael, Muller, Kristine M., Neira, Susana C., Pickrell, Alexander J., Rivenzon-Segal, Dalia, Schutz, Nili, Sharadendu, Anurag, Yu, Xiang, Zhang, Zhaoda, Buys, Janet, Fiorino, Mike, Gore, Anu, Horner, Michelle, Itano, Andrea, McElvain, Michele, Middleton, Scot, Schrag, Michael, Vargas, Hugo M., Xu, Han, Xu, Yang, Zhang, Xuxia, Siu, Jerry, Bürli, Roland W.

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