Search Results - "Sitte, H. H."

Amphetamines, new psychoactive drugs and the monoamine transporter cycle by Sitte, Harald H, Freissmuth, Michael

“…Highlights • Amphetamines comprise both plasma-membrane transporter substrates and blockers. • Amphetamines elicit psychostimulant effects which can lead to…”
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Shock Wave Treatment Enhances Cell Proliferation and Improves Wound Healing by ATP Release-coupled Extracellular Signal-regulated Kinase (ERK) Activation by Weihs, Anna M., Fuchs, Christiane, Teuschl, Andreas H., Hartinger, Joachim, Slezak, Paul, Mittermayr, Rainer, Redl, Heinz, Junger, Wolfgang G., Sitte, Harald H., Rünzler, Dominik

“…Shock wave treatment accelerates impaired wound healing in diverse clinical situations. However, the mechanisms underlying the beneficial effects of shock…”
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Structural basis of organic cation transporter-3 inhibition by Khanppnavar, Basavraj, Maier, Julian, Herborg, Freja, Gradisch, Ralph, Lazzarin, Erika, Luethi, Dino, Yang, Jae-Won, Qi, Chao, Holy, Marion, Jäntsch, Kathrin, Kudlacek, Oliver, Schicker, Klaus, Werge, Thomas, Gether, Ulrik, Stockner, Thomas, Korkhov, Volodymyr M., Sitte, Harald H.

“…Organic cation transporters (OCTs) facilitate the translocation of catecholamines, drugs and xenobiotics across the plasma membrane in various tissues…”
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Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter by Anderluh, Andreas, Hofmaier, Tina, Klotzsch, Enrico, Kudlacek, Oliver, Stockner, Thomas, Sitte, Harald H., Schütz, Gerhard J.

“…The human serotonin transporter (hSERT) mediates uptake of serotonin from the synaptic cleft and thereby terminates serotonergic signalling. We have previously…”
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Powerful Cocaine-Like Actions of 3,4-Methylenedioxypyrovalerone (MDPV), a Principal Constituent of Psychoactive 'Bath Salts' Products by BAUMANN, Michael H, PARTILLA, John S, BRANDT, Simon D, TELLA, Srihari R, COZZI, Nicholas V, SCHINDLER, Charles W, LEHNER, Kurt R, THORNDIKE, Eric B, HOFFMAN, Alexander F, HOLY, Marion, ROTHMAN, Richard B, GOLDBERG, Steven R, LUPICA, Carl R, SITTE, Harald H

“…The abuse of psychoactive 'bath salts' containing cathinones such as 3,4-methylenedioxypyrovalerone (MDPV) is a growing public health concern, yet little is…”
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Ethanol inhibits dopamine uptake via organic cation transporter 3: Implications for ethanol and cocaine co-abuse by Clauss, N. J., Mayer, F. P., Owens, W. A., Vitela, M., Clarke, K. M., Bowman, M. A., Horton, R. E., Gründemann, D., Schmid, D., Holy, M., Gould, G. G., Koek, W., Sitte, H. H., Daws, L. C.

“…Concurrent cocaine and alcohol use is among the most frequent drug combination, and among the most dangerous in terms of deleterious outcomes. Cocaine…”
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reverse operation of Na⁺/Cl⁻-coupled neurotransmitter transporters - why amphetamines take two to tango by Sitte, Harald H, Freissmuth, Michael

“…Sodium-chloride coupled neurotransmitter transporters achieve reuptake of their physiological substrate by exploiting the pre-existing sodium-gradient across…”
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An unsuspected role for organic cation transporter 3 in the actions of amphetamine by Mayer, Felix P, Schmid, Diethart, Owens, W Anthony, Gould, Georgianna G, Apuschkin, Mia, Kudlacek, Oliver, Salzer, Isabella, Boehm, Stefan, Chiba, Peter, Williams, Piper H, Wu, Hsiao-Huei, Gether, Ulrik, Koek, Wouter, Daws, Lynette C, Sitte, Harald H

“…Amphetamine abuse is a major public health concern for which there is currently no effective treatment. To develop effective treatments, the mechanisms by…”
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Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors by Gradisch, Ralph, Schlögl, Katharina, Lazzarin, Erika, Niello, Marco, Maier, Julian, Mayer, Felix P., Alves da Silva, Leticia, Skopec, Sophie M. C., Blakely, Randy D., Sitte, Harald H., Mihovilovic, Marko D., Stockner, Thomas

“…The presynaptic serotonin transporter (SERT) clears extracellular serotonin following vesicular release to ensure temporal and spatial regulation of…”
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Cross-sectional survey and Bayesian network model analysis of traditional Chinese medicine in Austria: investigating public awareness, usage determinants and perception of scientific support by Eigenschink, Michael, Bellach, Luise, Leonard, Sebastian, Dablander, Tom Eric, Maier, Julian, Dablander, Fabian, Sitte, Harald H

“…ObjectivesDespite the paucity of evidence verifying its efficacy and safety, traditional Chinese medicine (TCM) is expanding in popularity and political…”
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Globus pallidus dopamine and Parkinson motor subtypes : Clinical and brain biochemical correlation by RAJPUT, A. H, SITTE, H. H, RAJPUT, A, FENTON, M. E, PIFL, C, HORNYKIEWICZ, O

“…Patients with Parkinson disease (PD) may be akinetic/rigid, be tremor dominant, or have comparable severity of these motor symptoms (classic). The…”
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Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters by Mayer, F P, Wimmer, L, Dillon‐Carter, O, Partilla, J S, Burchardt, N V, Mihovilovic, M D, Baumann, M H, Sitte, H H

“…Background and Purpose 4‐Methyl‐N‐methylcathinone (mephedrone) is a synthetic stimulant that acts as a substrate‐type releaser at transporters for dopamine…”
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Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones by Duart-Castells, L., Nadal-Gratacós, N., Muralter, M., Puster, B., Berzosa, X., Estrada-Tejedor, R., Niello, M., Bhat, S., Pubill, D., Camarasa, J., Sitte, H.H., Escubedo, E., López-Arnau, R.

“…The emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, they are quickly replaced by new structurally related…”
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A transporter's doom or destiny: SLC6A1 in health and disease, novel molecular targets and emerging therapeutic prospects by Shah, Nikita, Kasture, Ameya S, Fischer, Florian P, Sitte, Harald H, Hummel, Thomas, Sucic, Sonja

“…As the first member of the solute carrier 6 (SLC6) protein family, the γ-aminobutyric acid (GABA) transporter 1 (GAT1, ), plays a pivotal role in the uptake of…”
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Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1-3 and Human Plasma Membrane Monoamine Transporter by Angenoorth, Thomas J F, Stankovic, Stevan, Niello, Marco, Holy, Marion, Brandt, Simon D, Sitte, Harald H, Maier, Julian

“…Many psychoactive compounds have been shown to primarily interact with high-affinity and low-capacity solute carrier 6 (SLC6) monoamine transporters for…”
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Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter by Li, Yang, Hasenhuetl, Peter S., Schicker, Klaus, Sitte, Harald H., Freissmuth, Michael, Sandtner, Walter

“…The dopamine transporter shapes dopaminergic neurotransmission by clearing extracellular dopamine and by replenishing vesicular stores. The dopamine…”
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Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter by Billesbølle, Christian B., Mortensen, Jonas S., Sohail, Azmat, Schmidt, Solveig G., Shi, Lei, Sitte, Harald H., Gether, Ulrik, Loland, Claus J.

“…Neurotransmitter/sodium symporters (NSSs) are responsible for Na + -dependent reuptake of neurotransmitters and represent key targets for antidepressants and…”
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Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release by Keighron, Jacqueline D., Bonaventura, Jordi, Li, Yang, Yang, Jae-Won, DeMarco, Emily M., Hersey, Melinda, Cao, Jianjing, Sandtner, Walter, Michaelides, Michael, Sitte, Harald H., Newman, Amy Hauck, Tanda, Gianluigi

“…Typical and atypical dopamine uptake inhibitors (DUIs) prefer distinct conformations of the dopamine transporter (DAT) to form ligand-transporter complexes,…”
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The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine by Steinkellner, Thomas, Freissmuth, Michael, Sitte, Harald H, Montgomery, Therese

“…Amphetamine ('Speed'), methamphetamine ('Ice') and its congener 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') are illicit drugs abused worldwide for…”
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Structure–Activity Relationship of Novel Second-Generation Synthetic Cathinones: Mechanism of Action, Locomotion, Reward, and Immediate-Early Genes by Nadal-Gratacós, Nuria, Alberto-Silva, Ana Sofia, Rodríguez-Soler, Míriam, Urquizu, Edurne, Espinosa-Velasco, Maria, Jäntsch, Kathrin, Holy, Marion, Batllori, Xavier, Berzosa, Xavier, Pubill, David, Camarasa, Jordi, Sitte, Harald H., Escubedo, Elena, López-Arnau, Raúl

“…Several new synthetic cathinones, which mimic the effect of classical psychostimulants such as cocaine or MDMA, have appeared in the global illicit drug market…”
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