Search Results - "Sitkowski, Jerzy"

New 5-Substituted SN38 Derivatives: A Stability Study and Interaction with Model Nicked DNA by NMR and Molecular Modeling Methods by Bednarek, Elżbieta, Bocian, Wojciech, Sitkowski, Jerzy, Urbanowicz, Magdalena, Kozerski, Lech

“…The new 5-substituted SN-38 derivatives, 5( )-(N-pyrrolidinyl)methyl-7-ethyl-10-hydroxycamptothecin ( ) and its diastereomer 5( ) ( ), were investigated using…”
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Insight on the Interaction between the Camptothecin Derivative and DNA Oligomer Mimicking the Target of Topo I Inhibitors by Bocian, Wojciech, Naumczuk, Beata, Urbanowicz, Magdalena, Sitkowski, Jerzy, Bednarek, Elżbieta, Wiktorska, Katarzyna, Pogorzelska, Anna, Wielgus, Ewelina, Kozerski, Lech

“…The understanding of the mechanism of Topo I inhibition by organic ligands is a crucial source of information that has led to the design of more effective and…”
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Novel Nontoxic 5,9-Disubstituted SN38 Derivatives: Characterization of Their Pharmacological Properties and Interactions with DNA Oligomers by Bednarek, Elżbieta, Bocian, Wojciech, Urbanowicz, Magdalena, Sitkowski, Jerzy, Naumczuk, Beata, Kozerski, Lech

“…Novel nontoxic derivatives of SN38 with favorable antineoplastic properties were characterized in water solution using NMR. The phenomena observed by NMR were…”
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Synthesis of Oxidized 3β,3′β-Disteryl Ethers and Search after High-Temperature Treatment of Sterol-Rich Samples by Zmysłowski, Adam, Sitkowski, Jerzy, Bus, Katarzyna, Michalska, Katarzyna, Szterk, Arkadiusz

“…It was proven that sterols subjected to high-temperature treatment can be concatenated, which results in polymeric structures, e.g., 3β,3′β-disteryl ethers…”
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Factors Affecting the Stability of Platinum(II) Complexes with 1,2,4-Triazolo[1,5- a ]pyrimidine Derivatives and Tetrahydrothiophene-1-Oxide or Diphenyl Sulfoxide by Jakubowski, Mateusz, Łakomska, Iwona, Kaszuba, Adriana, Wojtczak, Andrzej, Sitkowski, Jerzy, Jarzęcki, Andrzej A

“…The platinum(II) complexes of general formula [PtCl (dstp)(S-donor)] were dstp 5,7-dimethyl-1,2,4-triazolo[1,5- ]-pyrimidine (dmtp),…”
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Platinum(II) Complexes with Bulky Disubstitute Triazolopyrimidines as Promising Materials for Anticancer Agents by Łakomska, Iwona, Śmiłowicz, Dariusz, Jakubowski, Mateusz, Sitkowski, Jerzy, Wojtczak, Andrzej

“…Herein, we present dicarboxylate platinum(II) complexes of the general formula [Pt(mal)(DMSO)(L)] and [Pt(CBDC)(DMSO)(L)], where L is dbtp…”
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Ruthenium(II) and Iridium(III) Complexes as Tested Materials for New Anticancer Agents by Masternak, Joanna, Gilewska, Agnieszka, Barszcz, Barbara, Łakomska, Iwona, Kazimierczuk, Katarzyna, Sitkowski, Jerzy, Wietrzyk, Joanna, Kamecka, Anna, Milczarek, Magdalena

“…The oncological use of cisplatin is hindered by its severe side effects and a very important resistance problem. To overcome these problems, scientists have…”
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The Mode of SN38 Derivatives Interacting with Nicked DNA Mimics Biological Targeting of Topo I Poisons by Bocian, Wojciech, Naumczuk, Beata, Urbanowicz, Magdalena, Sitkowski, Jerzy, Bierczyńska-Krzysik, Anna, Bednarek, Elżbieta, Wiktorska, Katarzyna, Milczarek, Małgorzata, Kozerski, Lech

“…The compounds 7-ethyl-9-(N-methylamino)methyl-10-hydroxycamptothecin (2) and 7-ethyl-9-(N-morpholino)methyl-10-hydroxycamptothecin (3) are potential…”
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Identification and structural characterization of four novel synthetic cathinones: α-methylaminohexanophenone (hexedrone, HEX), 4-bromoethcathinone (4-BEC), 4-chloro-α-pyrrolidinopropiophenone (4-Cl-PPP), and 4-bromo-α-pyrrolidinopentiophenone (4-Br-PVP) after their seizures by Błażewicz, Agata, Bednarek, Elżbieta, Sitkowski, Jerzy, Popławska, Magdalena, Stypułkowska, Karolina, Bocian, Wojciech, Kozerski, Lech

“…Over 560 new psychoactive substances have been detected via the European Union Early Warning System (EU-EWS) of the European Monitoring Centre for Drugs and…”
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Structure of human insulin monomer in water/acetonitrile solution by Bocian, Wojciech, Sitkowski, Jerzy, Bednarek, Elżbieta, Tarnowska, Anna, Kawęcki, Robert, Kozerski, Lech

“…Here we present evidence that in water/acetonitrile solvent detailed structural and dynamic information can be obtained for important proteins that are…”
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A novel isoquinoline alkaloid, DD-carboxypeptidase inhibitor, with antibacterial activity isolated from Streptomyces sp. 8812. Part II: Physicochemical properties and structure elucidation by Solecka, Jolanta, Sitkowski, Jerzy, Bocian, Wojciech, Bednarek, Elżbieta, Kawęcki, Robert, Kozerski, Lech

“…A novel antimicrobial agent labeled JS-1, being a member of isoquinoline alkaloids, of molecular formula C 10 H 9 NO 4 was isolated from the culture broth of…”
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Multiple Binding Modes of the Camptothecin Family to DNA Oligomers by Bocian, Wojciech, Kawȩcki, Robert, Bednarek, Elzbieta, Sitkowski, Jerzy, Pietrzyk, Agnieszka, Williamson, Michael P., Hansen, Poul Erik, Kozerski, Lech

“…The binding constants of camptothecin, topotecan and its lactone ring‐opened carboxylate derivative to DNA octamers were measured by UV and NMR spectroscopy…”
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UPLC-MS/MS determination of steroid hormones via a novel reaction based on derivatisation by a cyclic-organophosphate by Szterk, Arkadiusz, Sitkowski, Jerzy, Bocian, Wojciech

“…A cyclic-organophosphate, specifically 2-chloro-5,5-dimethyl-1,3,2-dioxaphosphorinane-2-oxide, was used to derivatise the hydroxyl group at the C3 position of…”
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The application of multidimensional NMR analysis to cis/trans isomers study of menaquinone-7 (vitamine K2MK-7), identification of the (E,Z3,E2,ω)-menaquinone-7 isomer in dietary supplements by Sitkowski, Jerzy, Bocian, Wojciech, Szterk, Arkadiusz

“…The aim of this paper was to determine the chemical structure of cis/trans isomers of vitamin K2MK-7 found in dietary supplements. Vitamin K2MK-7 was…”
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Hydrophilic platinum(II) complexes containing 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine: Spectroscopic and in vitro cytotoxic characterization by Łakomska, Iwona, Hoffmann, Kamil, Sitkowski, Jerzy

“…Four platinum(II) complexes containing 5,7-methyl-1,2,4-triazolo[1,5-a]pyrimidine(dmtp) of the general formula cis-[Pt(X)2(dmtp)2], where X – acetato (1),…”
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Separation of menaquinone-7 geometric isomers by semipreparative high-performance liquid chromatography with silver complexation and identification by nuclear magnetic resonance by Bus, Katarzyna, Sitkowski, Jerzy, Bocian, Wojciech, Zmysłowski, Adam, Ofiara, Karol, Szterk, Arkadiusz

“…[Display omitted] •The semipreparative chromatographic method with silver complexation was developed.•Theoretical calculations were used to determine…”
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Purification of Commercially Available β‐Sitosterol via Chemical Synthesis by Zmysłowski, Adam, Sitkowski, Jerzy, Michalska, Katarzyna, Szterk, Arkadiusz

“…β‐Sitosterol, a plant sterol, is found to be useful in the nutraceutical and pharmaceutical industries, but is also frequently employed in biological research…”
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Structural characteristics and biological properties of new pseudo-octahedral ruthenium(II) complexes containing a biphenyl moiety by Kaszuba, Adriana, Barwiołek, Magdalena, Sitkowski, Jerzy, Wojtczak, Andrzej, Łakomska, Iwona

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Similarities and differences in d6 low-spin ruthenium, rhodium and iridium half-sandwich complexes: synthesis, structure, cytotoxicity and interaction with biological targets by Gilewska, Agnieszka, Barszcz, Barbara, Masternak, Joanna, Kazimierczuk, Katarzyna, Sitkowski, Jerzy, Wietrzyk, Joanna, Turlej, Eliza

“…In this paper, we discussed the similarities and differences in d 6 low-spin half-sandwich ruthenium, rhodium and iridium complexes containing 2,2′-biimidazole…”
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Synthesis and search for 3β,3′β-disteryl ethers after high-temperature treatment of sterol-rich samples by Zmysłowski, Adam, Sitkowski, Jerzy, Bus, Katarzyna, Ofiara, Karol, Szterk, Arkadiusz

“…•3β,3′β-disteryl ethers were prepared from the reaction of sterols with MK10 catalyst.•The GC–MS method for analysing 3β,3′β-disteryl ethers was developed and…”
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