Search Results - "Sitkovsky, Michail V."

Immunological mechanisms of the antitumor effects of supplemental oxygenation by Hatfield, Stephen M, Kjaergaard, Jorgen, Lukashev, Dmitriy, Schreiber, Taylor H, Belikoff, Bryan, Abbott, Robert, Sethumadhavan, Shalini, Philbrook, Phaethon, Ko, Kami, Cannici, Ryan, Thayer, Molly, Rodig, Scott, Kutok, Jeffrey L, Jackson, Edwin K, Karger, Barry, Podack, Eckhard R, Ohta, Akio, Sitkovsky, Michail V

“…Antitumor T cells either avoid or are inhibited in hypoxic and extracellular adenosine-rich tumor microenvironments (TMEs) by A2A adenosine receptors. This may…”
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Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells by Sethumadhavan, Shalini, Silva, Murillo, Philbrook, Phaethon, Nguyen, Thao, Hatfield, Stephen M, Ohta, Akio, Sitkovsky, Michail V

“…Human cancers are known to downregulate Major Histocompatibility Complex (MHC) class I expression thereby escaping recognition and rejection by anti-tumor T…”
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Hypoxia-Adenosinergic Immunosuppression: Tumor Protection by T Regulatory Cells and Cancerous Tissue Hypoxia by Sitkovsky, Michail V, Kjaergaard, Jorgen, Lukashev, Dmitriy, Ohta, Akio

“…Cancerous tissue protection from tumor-recognizing CD8 + and CD4 + T cells (antitumor T cells) limits the therapeutic potential of immunotherapies. We propose…”
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Immunomodulatory and neuroprotective effects of inosine by Haskó, György, Sitkovsky, Michail V., Szabó, Csaba

“…Adenosine has been considered as a potential immunomodulatory and neuroprotective agent for 30 years. Inosine, a major degradation product of adenosine, was…”
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Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes by Silva, Murillo, Nguyen, Thao H., Philbrook, Phaethon, Chu, Matthew, Sears, Olivia, Hatfield, Stephen, Abbott, Robert K., Kelsoe, Garnett, Sitkovsky, Michail V.

“…Rapidly evolving pathogens such as HIV or influenza can quickly mutate their antigenic profiles, reducing the efficacy of conventional vaccines. Despite this…”
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Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury by Thiel, Manfred, Chouker, Alexander, Ohta, Akio, Jackson, Edward, Caldwell, Charles, Smith, Patrick, Lukashev, Dmitry, Bittmann, Iris, Sitkovsky, Michail V

“…Acute respiratory distress syndrome (ARDS) usually requires symptomatic supportive therapy by intubation and mechanical ventilation with the supplemental use…”
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Toll-like Receptor 3 Regulates Angiogenesis and Apoptosis in Prostate Cancer Cell Lines through Hypoxia-Inducible Factor 1α by Paone, Alessio, Galli, Roberta, Gabellini, Chiara, Lukashev, Dmitriy, Starace, Donatella, Gorlach, Agnes, De Cesaris, Paola, Ziparo, Elio, Del Bufalo, Donatella, Sitkovsky, Michail V., Filippini, Antonio, Riccioli, Anna

“…Toll-like receptors (TLRs) recognize microbial/viral-derived components that trigger innate immune response and conflicting data implicate TLR agonists in…”
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Differential requirement for A2a and A3 adenosine receptors for the protective effect of inosine in vivo by Gomez, Gregorio, Sitkovsky, Michail V.

“…Inosine is an endogenous nucleoside with immunosuppressive properties that is known to inhibit the accumulation of proinflammatory cytokines and protect mice…”
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Mechanisms of Disease: Purinergic Signaling during Inflammation by Eltzschig, Holger K, Sitkovsky, Michail V, Robson, Simon C

“…Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is mainly proinflammatory, and adenosine signaling is mainly…”
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Purinergic Signaling during Inflammation by Eltzschig, Holger K, Sitkovsky, Michail V, Robson, Simon C

“…Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is mainly proinflammatory, and adenosine signaling is mainly…”
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Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy by Hatfield, Stephen M, Sitkovsky, Michail V

“…Hypoxia/HIF-1α- and extracellular adenosine/A2 adenosine receptor-mediated immunosuppression protects tissues from collateral damage by antipathogen immune…”
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Differential regulation of HIF-1α isoforms in murine macrophages by TLR4 and adenosine A2A receptor agonists by Ramanathan, Madhuri, Luo, Wenting, Csóka, Balázs, Haskó, György, Lukashev, Dmitry, Sitkovsky, Michail V., Leibovich, Samuel Joseph

“…Up‐regulation of adenosine A2A receptors (A2ARs) and the HIF‐1αl. 1 isoform plays an important role in the switch of macrophages from an inflammatory (M1) to…”
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The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases by THIEL, Manfred, CALDWELL, Charles C, SITKOVSKY, Michail V

“…Adenosine can be described as a retaliatory metabolite, the production and release of which is usually enhanced under adverse environmental conditions. Binding…”
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T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response by Sitkovsky, Michail V

“…T regulatory cells (Treg cells) suppress immune responses to maintain self tolerance, but they also protect cancerous tissues. I propose a model to potentially…”
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Sufficient numbers of anti-tumor T cells is a condition of maximal efficacy of anti-hypoxia-A2-adenosinergic drugs during cancer immunotherapy by Sitkovsky, Michail V

“…•Discoveries of hypoxia-adenosine pathway and credit to teams of contributing authors.•Limitation of anti-hypoxia-adenosinergic treatments in…”
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Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists by Sitkovsky, Michail V, Hatfield, Stephen, Abbott, Robert, Belikoff, Bryan, Lukashev, Dmitriy, Ohta, Akio

“…Hypoxia-driven, A2A adenosine receptor (A2AR)-mediated (hypoxia-A2-adenosinergic), T-cell-autonomous immunosuppression was first recognized as critical and…”
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Adenosine A2A Receptor Is Involved in Cell Surface Expression of A2B Receptor by Moriyama, Kengo, Sitkovsky, Michail V.

“…The A2A and A2B adenosine receptors (A2AR and A2BR) are implicated in many physiological processes. However, the mechanisms of their intracellular maturation…”
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Oxygen‐Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors by Colombani, Thibault, Eggermont, Loek J., Hatfield, Stephen M., Rogers, Zachary J., Rezaeeyazdi, Mahboobeh, Memic, Adnan, Sitkovsky, Michail V., Bencherif, Sidi A.

“…Solid tumors are protected from antitumor immune responses due to their hypoxic microenvironments. Weakening hypoxia‐driven immunosuppression by hyperoxic…”
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Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors by Sitkovsky, Michail V, Lukashev, Dmitriy, Apasov, Sergey, Kojima, Hidefumi, Koshiba, Masahiro, Caldwell, Charles, Ohta, Akio, Thiel, Manfred

“…Immune cell-mediated destruction of pathogens may result in excessive collateral damage to normal tissues, and the failure to control activated immune cells…”
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Use of the A 2A adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo by Sitkovsky, Michail V

“…Inflammation must be inhibited in order to treat, e.g., sepsis or autoimmune diseases or must be selectively enhanced to improve, for example, immunotherapies…”
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