Search Results - "Sithanandam, Gunamani"

Inactivation of ErbB3 by siRNA promotes apoptosis and attenuates growth and invasiveness of human lung adenocarcinoma cell line A549 by SITHANANDAM, Gunamani, FORNWALD, Laura W, FIELDS, Janet, ANDERSON, Lucy M

“…The ErbB3 receptor and the downstream signaling kinase Akt are implicated in proliferation of lung adenocarcinoma cells. Inhibition by siRNAs to ErbB3 and Akt…”
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3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways by Ludwig, Stephan, Engel, Katrin, Hoffmeyer, Angelika, Sithanandam, Gunamani, Neufeld, Bernd, Palm, Dieter, Gaestel, Matthias, Rapp, Ulf R.

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Developmental Regulation of Mitogen-Activated Protein Kinase-Activated Kinases-2 and -3 (MAPKAPK-2/-3) in Vivo during Corpus Luteum Formation in the Rat by Maizels, Evelyn T, Mukherjee, Abir, Sithanandam, Gunamani, Peters, Carl A, Cottom, Joshua, Mayo, Kelly E, Hunzicker-Dunn, Mary

“…The current study investigates the activation in vivo and regulation of the expression of components of the p38 mitogen-activated protein kinase (MAPK) pathway…”
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Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction by HONG CAI, ERHARDT, P, TROPPMAIR, J, DIAZ-MECO, M. T, GUNAMANI SITHANANDAM, RAPP, U. R, MOSCAT, J, COOPER, G. M

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3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region by Sithanandam, Gunamani, Latif, Farida, Duh, Fuh-Mei, Bernal, Ricardo, Smola, Ute, Li, Hua, Kuzmin, Igor, Wixler, Viktor, Geil, Laura, Shrestha, Sadeep, Lloyd, Patricia A., Bader, Scott, Sekido, Yoshitaka, Tartof, Kenneth D., Kashuba, Vladimir I., Zabarovsky, Eugene R., Dean, Michael, Klein, George, Lerman, Michael I., Minna, John D., Rapp, Ulf R., Allikmets, Rando

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Selective mutation of K-ras by N-ethylnitrosourea shifts from codon 12 to codon 61 during fetal mouse lung maturation by SITHANANDAM, G, RAMAKRISHNA, G, DIWAN, B. A, ANDERSON, L. M

“…Fetal mouse lung before gestation day 17 shows unique sensitivity to causation of rapidly growing tumors by N-ethylnitrosourea (ENU). Since mouse lung tumors…”
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B-raf and a B-raf pseudogene are located on 7q in man by Sithanandam, G, Druck, T, Cannizzaro, L A, Leuzzi, G, Huebner, K, Rapp, U R

“…The B-raf gene was localized to human chromosome region 7p11-7qter by Southern blot analysis of its segregation in a panel of rodent-human hybrids, using a…”
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K-Ras p21 EXPRESSION AND ACTIVITY IN LUNG AND LUNG TUMORS by Gayatri Ramakrishna, Gunamani Sithanandam, Robert Y. S. Cheng, Laura W. Fornwald, George T. Smith, Bhalchandra A. Diwan, Lucy M. Anderson

“…Although K-ras is mutated in many human and mouse lung adenocarcinomas, the function of K-ras p21 in lung is not known. We sought evidence for the prevalent…”
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Anti-tumor efficacy of naked siRNAs for ERBB3 or AKT2 against lung adenocarcinoma cell xenografts by Sithanandam, Gunamani, Fornwald, Laura W., Fields, Janet R., Morris, Nicole L., Anderson, Lucy M.

“…The use of siRNAs against specific molecular targets has potential for cancer therapy but has been thought to be limited by the need for formulation to improve…”
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Mutant K-ras super(V12) increases COX-2, peroxides and DNA damage in lung cells by Maciag, Anna, Sithanandam, Gunamani, Anderson, Lucy M

“…K-ras is frequently mutated in lung adenocarcinomas. Recent discovery that wild-type K-ras is tumor suppressive in the lung raises a question: how is mutant…”
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Alternate Paths from Epidermal Growth Factor Receptor to Akt in Malignant Versus Nontransformed Lung Epithelial Cells: ErbB3 Versus Gab1 by Sithanandam, Gunamani, Smith, George T, Fields, Janet R, Fornwald, Laura W, Anderson, Lucy M

“…In many human lung adenocarcinoma cell lines, a pathway involving epidermal growth factor receptor (EGFR), ErbB2 and ErbB3 receptors, phosphatidyl inositol…”
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Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathway by Sithanandam, Gunamani, Smith, George T., Masuda, Akira, Takahashi, Takashi, Anderson, Lucy M., Fornwald, Laura W.

“…Although ErbB3, a member of the epidermal growth factor receptor family, has been implicated in mammary tumorigenesis, investigation of its role in lung…”
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Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells by Maciag, Anna, Sithanandam, Gunamani, Anderson, Lucy M.

“…K-ras is frequently mutated in lung adenocarcinomas. Recent discovery that wild-type K-ras is tumor suppressive in the lung raises a question: how is mutant…”
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95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site by Stephens, R M, Sithanandam, G, Copeland, T D, Kaplan, D R, Rapp, U R, Morrison, D K

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The phosphorylation and activation of B-raf in PC12 cells stimulated by nerve growth factor by OSHIMA, M, SITHANANDAM, G, RAPP, U.-R, GUROFF, G

“…Treatment of PC12 cells with nerve growth factor does not alter the levels of B-raf mRNA, but does induce rapid phosphorylation of B-raf proteins…”
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A single point mutation in the envelope gene is responsible for replication and XC fusion deficiency of the endogenous ecotropic C3H/He murine leukemia virus and for its repair in culture by GUNAMANI SITHANANDAM, RAPP, U. R

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Hydrolysis of Phosphatidylcholine Couples Ras to Activation of Raf Protein Kinase During Mitogenic Signal Transduction by Cai, Hong, Erhardt, Peter, Troppmair, Jakob, Diaz-Meco, Maria T., Sithanandam, Gunamani, Rapp, Ulf R., Moscat, Jorge, Cooper, Geoffrey M.

“…We have investigated the relationship between hydrolysis of phosphatidylcholine (PC) and activation of the Raf-1 protein kinase in Ras-mediated transduction of…”
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95-Kilodalton B-Raf Serine/Threonine Kinase: Identification of the Protein and Its Major Autophosphorylation Site by Stephens, Robert M., Sithanandam, Gunamani, Copeland, Terry D., Kaplan, David R., Rapp, Ulf R., Morrison, Deborah K.

“…B-Raf, a member of the Raf family of serine/threonine kinases, is expressed primarily in the brain and in the nervous system. In this study, the biochemical…”
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Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence by Kammouni, Wafa, Ramakrishna, Gayatri, Sithanandam, Gunamani, Smith, George T, Fornwald, Laura W, Masuda, Akira, Takahashi, Takashi, Anderson, Lucy M

“…Although K-ras is frequently mutated in lung adenocarcinomas, the normal function of K-ras p21 in lung is not known. In two mouse (E10 and C10) and one human…”
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