Search Results - "Sitar, Daniel S"

Quantification of cefazolin in serum and adipose tissue by ultra high performance liquid chromatography-Tandem mass spectrometry (UHPLC–MS/MS): application to a pilot study of obese women undergoing cesarean delivery by Lillico, Ryan, Sayre, Casey L., Sitar, Daniel S., Davies, Neal M., Baron, Cynthia M., Lakowski, Ted M.

“…•The first UHPLC–MS/MS assay using a stable-isotope cefazolin internal standard.•Cefazolin is extracted from adipose tissue using a hexane/buffer solvent…”
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Use of amantadine in the evaluation of response to chemotherapy in lung cancer: a pilot study by Maksymiuk, Andrew W, Tappia, Paramjit S, Bux, Rashid Ahmed, Moyer, Dante, Huang, Guoyu, Joubert, Philippe, Miller, Donald W, Ramjiawan, Bram, Sitar, Daniel S

“…The assessment of tumor response to therapy is of critical importance as it permits for a prospective end point evaluation and provides a guide to clinicians…”
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Theophylline-7β-d-Ribofuranoside (Theonosine), a New Theophylline Metabolite Generated in Human and Animal Lung Tissue by Sitar, Daniel S, Bowen, James M, He, Juan, Tesoro, Angelo, Spino, Michael

“…While assessing the ability of mammalian lung tissue to metabolize theophylline, a new metabolite was isolated and characterized. The metabolite was produced…”
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The Influence of Sparse Data Sampling on Population Pharmacokinetics: A Post Hoc Analysis of a Pharmacokinetic Study of Morphine in Healthy Volunteers by Ariano, Robert E., PharmD, Duke, Peter C., MD, Sitar, Daniel S., PhD

“…Abstract Background Intensive sampling of patients for drugs with complex pharmacokinetic profiles is difficult to perform in the clinic or hospitalized…”
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Predictive value and clinical significance of increased SSAT-1 activity in healthy adults by Tappia, Paramjit S, Maksymiuk, Andrew W, Sitar, Daniel S, Akhtar, Parveen S, Khatun, Nazrina, Parveen, Rahnuma, Ahmed, Rashiduzzaman, Ahmed, Rashid B, Cheng, Brian, Huang, Gina, Bach, Horacio, Hiebert, Brett, Ramjiawan, Bram

“…Spermidine/spermine N -acetyltransferase (SSAT-1) regulates cell growth, proliferation and death. Amantadine is converted by SSAT-1 to acetylamantadine (AA)…”
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Adequacy of a Vancomycin Dosing Regimen in Patients Receiving High-Flux Hemodialysis by Ariano, Robert E., Fine, Adrian, Sitar, Daniel S., Rexrode, Stacey, Zelenitsky, Sheryl A.

“…Background: Some investigators have recommended the convenient practice of administering vancomycin doses during the last hour of the hemodialysis treatment…”
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A High-Performing Plasma Metabolite Panel for Early-Stage Lung Cancer Detection by Zhang, Lun, Zheng, Jiamin, Ahmed, Rashid, Huang, Guoyu, Reid, Jennifer, Mandal, Rupasri, Maksymuik, Andrew, Sitar, Daniel S, Tappia, Paramjit S, Ramjiawan, Bram, Joubert, Philippe, Russo, Alessandro, Rolfo, Christian D, Wishart, David S

“…The objective of this research is to use metabolomic techniques to discover and validate plasma metabolite biomarkers for the diagnosis of early-stage…”
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The evolving role of the Journal of Clinical Pharmacology and its contributions to the discipline by Sitar, Daniel S.

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Pill count, self-report, and pharmacy claims data to measure medication adherence in the elderly by Grymonpre, RE, Didur, CD, Montgomery, PR, Sitar, DS

“…OBJECTIVE: To compare medication adherence calculated from four different data sources including a pill count and self-report obtained during a home medication…”
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Safe use of the CXCR4 inhibitor ALX40-4C in humans by Doranz, B J, Filion, L G, Diaz-Mitoma, F, Sitar, D S, Sahai, J, Baribaud, F, Orsini, M J, Benovic, J L, Cameron, W, Doms, R W

“…ALX40-4C is a small peptide inhibitor of the chemokine receptor CXCR4 that can inhibit X4 strains of HIV-1. Prior to the discovery of chemokine receptors as…”
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Validity of a Prescription Claims Database to Estimate Medication Adherence in Older Persons by Grymonpre, Ruby, Cheang, Mary, Fraser, Marjory, Metge, Colleen, Sitar, Daniel S.

“…Background: Prescription claims data have been used to estimate refill medication adherence through calculations of cumulative medication acquisition (CMA) and…”
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Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza by Ariano, Robert E, Sitar, Daniel S, Zelenitsky, Sheryl A, Zarychanski, Ryan, Pisipati, Amarnath, Ahern, Stéphane, Kanji, Salmaan, Rello, Jordi, Kumar, Anand

“…Whether the enteric absorption of the neuraminidase inhibitor oseltamivir is impaired in critically ill patients is unknown. We documented the pharmacokinetic…”
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Spermidine/Spermine N1-Acetyltransferase 1 (SAT1)—A Potential Gene Target for Selective Sensitization of Glioblastoma Cells Using an Ionizable Lipid Nanoparticle to Deliver siRNA by Yathindranath, Vinith, Safa, Nura, Sajesh, Babu V, Schwinghamer, Kelly, Vanan, Magimairajan Issai, Bux, Rashid, Sitar, Daniel S, Pitz, Marshall, Siahaan, Teruna J, Miller, Donald W

“…Spermidine/spermine N1-acetyltransferase 1 (SAT1) responsible for cell polyamine catabolism is overexpressed in glioblastoma multiforme (GB). Its role in tumor…”
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In vitro evaluation of the effect of linezolid and levofloxacin on Bacillus anthracis toxin production, spore formation and cell growth by Head, Breanne M, Alfa, Michelle, Sitar, Daniel S, Rubinstein, Ethan, Meyers, Adrienne F A

“…Owing to its ability to form spores and toxins, Bacillus anthracis is considered a bioterror agent. Although current therapeutic strategies can be effective,…”
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The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules by Goralski, Kerry B, Lou, Ganlu, Prowse, Matthew T, Gorboulev, Valentin, Volk, Christopher, Koepsell, Hermann, Sitar, Daniel S

“…In renal proximal tubules, the organic cation transporters rOCT1 and rOCT2 are supposed to mediate the first step in organic cation secretion. We investigated…”
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Liquid Biopsy in Lung Cancer Screening: The Contribution of Metabolomics. Results of A Pilot Study by Singhal, Sandeep, Rolfo, Christian, Maksymiuk, Andrew W, Tappia, Paramjit S, Sitar, Daniel S, Russo, Alessandro, Akhtar, Parveen S, Khatun, Nazrina, Rahnuma, Parveen, Rashiduzzaman, Ahmed, Ahmed Bux, Rashid, Huang, Guoyu, Ramjiawan, Bram

“…: Lung cancer is the most common cause of cancer-related deaths worldwide. Early diagnosis is crucial to increase the curability chance of the patients. Low…”
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Spermidine/spermine N1 -acetyltransferase-1 as a diagnostic biomarker in human cancer by Maksymiuk, Andrew W, Sitar, Daniel S, Ahmed, Rashid, Cheng, Brian, Bach, Horacio, Bagchi, Rushita Adhikari, Aroutiounova, Nina, Tappia, Paramjit S, Ramjiawan, Bram

“…SSAT-1 is an enzyme that plays a critical role in cell growth. Amantadine, a FDA-approved antiviral drug, is a substrate for SSAT-1. The utility of amantadine…”
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Protective Effect of Minocycline Treatment on Striatal Ischemia by Peeling, James, Yan, Huijin, Buist, Richard, Sitar, Daniel S., Corbett, Dale

“…Minocycline reduces infarct volume measured up to 1 week after focal cerebral ischemia, but it has not been shown that this results in lasting improvement in…”
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Oseltamivir, an Influenza Neuraminidase Inhibitor Drug, Does Not Affect the Steady-State Pharmacokinetic Characteristics of Cyclosporine, Mycophenolate, or Tacrolimus in Adult Renal Transplant Patients by LAM, Herman, JEFFERY, John, SITAR, Daniel S, AOKI, Fred Y

“…An influenza neuraminidase inhibitor drug, oseltamivir (Os) may be prescribed to renal transplant patients to prevent and treat influenza A and B illness. A…”
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Clinical pharmacology confounders in older adults by Sitar, Daniel S

“…Major advances produced by healthcare research have resulted in an increasing number of drugs that may be used to modify disease expression and improve quality…”
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