Search Results - "Sita, Giulia"

NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration by Sita, Giulia, Graziosi, Agnese, Hrelia, Patrizia, Morroni, Fabiana

“…Amyloid beta (Aβ)-induced abnormal neuroinflammation is recognized as a major pathological feature of Alzheimer’s disease (AD), which results in memory…”
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Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway by Morroni, Fabiana, Sita, Giulia, Graziosi, Agnese, Turrini, Eleonora, Fimognari, Carmela, Tarozzi, Andrea, Hrelia, Patrizia

“…Alzheimer's disease (AD) is a progressive pathology, where dementia symptoms gradually worsen over a number of years. The hallmarks of AD, such as amyloid…”
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Isothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson's Disease by Sita, Giulia, Hrelia, Patrizia, Tarozzi, Andrea, Morroni, Fabiana

“…Parkinson's disease (PD) is recognized as the second most common neurodegenerative disorder and is characterized by a slow and progressive degeneration of…”
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Sulforaphane Causes Cell Cycle Arrest and Apoptosis in Human Glioblastoma U87MG and U373MG Cell Lines under Hypoxic Conditions by Sita, Giulia, Graziosi, Agnese, Hrelia, Patrizia, Morroni, Fabiana

“…Glioblastoma multiforme (GBM) is the most prevalent and aggressive primary brain tumor. The median survival rate from diagnosis ranges from 15 to 17 months…”
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Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment by Sita, Giulia, Hrelia, Patrizia, Graziosi, Agnese, Morroni, Fabiana

“…Sulforaphane (SFN), an isothiocyanate (ITC) derived from cruciferous vegetables, particularly broccoli and broccoli sprouts, has been widely investigated due…”
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The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones by de Freitas Silva, Matheus, Pruccoli, Letizia, Morroni, Fabiana, Sita, Giulia, Seghetti, Francesca, Viegas, Claudio, Tarozzi, Andrea

“…Chalcones have shown a broad spectrum of biological activities with clinical potential against various diseases. The biological activities are mainly…”
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P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer’s Disease by Morroni, Fabiana, Tarozzi, Andrea, Hrelia, Patrizia, Sita, Giulia

“…ATP-binding cassette (ABC) transporters, in particular P-glycoprotein (encoded by ABCB1), are important and selective elements of the blood-brain barrier…”
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Cross-disease analysis of Alzheimer’s disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases by Caberlotto, Laura, Nguyen, T.-Phuong, Lauria, Mario, Priami, Corrado, Rimondini, Roberto, Maioli, Silvia, Cedazo-Minguez, Angel, Sita, Giulia, Morroni, Fabiana, Corsi, Mauro, Carboni, Lucia

“…Evidence is accumulating that the main chronic diseases of aging Alzheimer’s disease (AD) and type-2 diabetes mellitus (T2DM) share common pathophysiological…”
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Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease by Morroni, Fabiana, Tarozzi, Andrea, Sita, Giulia, Bolondi, Cecilia, Zolezzi Moraga, Juan Manuel, Cantelli-Forti, Giorgio, Hrelia, Patrizia

“…•Sulforaphane (SFN) improves motor impairments in 6-OHDA-lesioned mice.•SFN protects dopaminergic neurons, reducing DNA fragmentation and caspase-3 activation…”
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Esculetin as a Bifunctional Antioxidant Prevents and Counteracts the Oxidative Stress and Neuronal Death Induced by Amyloid Protein in SH-SY5Y Cells by Pruccoli, Letizia, Morroni, Fabiana, Sita, Giulia, Hrelia, Patrizia, Tarozzi, Andrea

“…Oxidative stress (OS) appears to be an important determinant during the different stages of progression of Alzheimer’s Disease (AD). In particular, impaired…”
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The Unfolded Protein Response in a Murine Model of Alzheimer’s Disease: Looking for Predictors by Sita, Giulia, Graziosi, Agnese, Corrieri, Camilla, Ghelli, Luca, Angelini, Sabrina, Cortelli, Pietro, Hrelia, Patrizia, Morroni, Fabiana

“…Alzheimer’s disease (AD) represents the most frequent type of dementia worldwide, and aging is the most important risk factor for the sporadic form of the…”
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Protective Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate on Aβ1-42-Induced Cognitive Deficit, Oxidative Stress, Inflammation, and Apoptosis in Mice by Morroni, Fabiana, Sita, Giulia, Graziosi, Agnese, Turrini, Eleonora, Fimognari, Carmela, Tarozzi, Andrea, Hrelia, Patrizia

“…Alzheimer’s disease (AD) is the most common form of dementia among older people. Although soluble amyloid species are recognized triggers of the disease, no…”
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TRPM2 in the Brain: Role in Health and Disease by Sita, Giulia, Hrelia, Patrizia, Graziosi, Agnese, Ravegnini, Gloria, Morroni, Fabiana

“…Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian…”
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Effects of Subtoxic Concentrations of Atrazine, Cypermethrin, and Vinclozolin on microRNA-Mediated PI3K/Akt/mTOR Signaling in SH-SY5Y Cells by Graziosi, Agnese, Sita, Giulia, Corrieri, Camilla, Angelini, Sabrina, d'Emmanuele di Villa Bianca, Roberta, Mitidieri, Emma, Sorrentino, Raffaella, Hrelia, Patrizia, Morroni, Fabiana

“…Endocrine-disrupting chemicals (EDCs) are different natural and synthetic chemicals that may interfere with several mechanisms of the endocrine system…”
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Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability by Andreev, Stanislav, Pantsar, Tatu, El-Gokha, Ahmed, Ansideri, Francesco, Kudolo, Mark, Anton, Débora Bublitz, Sita, Giulia, Romasco, Jenny, Geibel, Christian, Lämmerhofer, Michael, Goettert, Márcia Ines, Tarozzi, Andrea, Laufer, Stefan A., Koch, Pierre

“…Glycogen synthase kinase-3β (GSK-3β) is a potential target in the field of Alzheimer’s disease drug discovery. We recently reported a new class of…”
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PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease by Morroni, Fabiana, Sita, Giulia, Graziosi, Agnese, Ravegnini, Gloria, Molteni, Raffaella, Paladini, Maria Serena, Dias, Kris Simone Tranches, Dos Santos, Ariele Faria, Viegas, Jr, Claudio, Camps, Ihosvany, Pruccoli, Letizia, Tarozzi, Andrea, Hrelia, Patrizia

“…Alzheimer's disease (AD) is the most frequent type of dementia in older people. The complex nature of AD calls for the development of multitarget agents…”
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Neuroprotective effects of erucin against 6-hydroxydopamine-induced oxidative damage in a dopaminergic-like neuroblastoma cell line by Tarozzi, Andrea, Morroni, Fabiana, Bolondi, Cecilia, Sita, Giulia, Hrelia, Patrizia, Djemil, Alice, Cantelli-Forti, Giorgio

“…Oxidative stress (OS) contributes to the cascade leading to the dysfunction or death of dopaminergic neurons during Parkinson's disease (PD). A strategy to…”
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Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells by Benakis, Corinne, Brea, David, Caballero, Silvia, Faraco, Giuseppe, Moore, Jamie, Murphy, Michelle, Sita, Giulia, Racchumi, Gianfranco, Ling, Lilan, Pamer, Eric G, Iadecola, Costantino, Anrather, Josef

“…Alterations in the gut microbiota affect stroke outcomes via modulation of T cells, suggesting a gut-brain axis linking commensal microbes with the CNS…”
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Early effects of Aβ1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways by Morroni, Fabiana, Sita, Giulia, Tarozzi, Andrea, Rimondini, Roberto, Hrelia, Patrizia

“…•Aβ oligomers (AβO) injection induces learning and memory impairments.•AβO injection increases oxidative stress and GSH levels.•AβO injection induces caspase-9…”
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Commensal microbiota affects ischemic stroke outcome by regulating intestinal gamma delta T cells by Benakis, Corinne, Brea, David, Caballero, Silvia, Faraco, Giuseppe, Moore, Jamie, Murphy, Michelle, Sita, Giulia, Racchumi, Gianfranco, Ling, Lilan, Pamer, Eric G, Iadecola, Costantino, Anrather, Josef

“…Commensal gut bacteria impact the host immune system and can influence disease processes in several organs, including the brain. However, it remains unclear…”
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