Search Results - "Sit, Clarissa S."

Electrochemical Surface-Enhanced Raman Spectroscopy as a Platform for Bacterial Detection and Identification by Lynk, Taylor P, Sit, Clarissa S, Brosseau, Christa L

“…The field of bacterial screening is in need of a rapid, easy to use, sensitive, and selective platform for bacterial detection and identification. Current…”
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Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile by Rea, Mary C, Sit, Clarissa S, Clayton, Evelyn, O'Connor, Paula M, Whittal, Randy M, Zheng, Jing, Vederas, John C, Ross, R. Paul, Hill, Colin

“…The last decade has seen numerous outbreaks of Clostridium difficile-associated disease (CDAD), which presented significant challenges for healthcare…”
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Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants by Sit, Clarissa S., Ruzzini, Antonio C., Van Arnam, Ethan B., Ramadhar, Timothy R., Currie, Cameron R., Clardy, Jon

“…Small molecules produced by Actinobacteria have played a prominent role in both drug discovery and organic chemistry. As part of a larger study of the…”
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Biosynthesis of Aminovinyl-Cysteine-Containing Peptides and Its Application in the Production of Potential Drug Candidates by Sit, Clarissa S, Yoganathan, Sabesan, Vederas, John C

“…Bacteria produce a wide array of metabolites to protect themselves from competing microbes. These antimicrobial compounds include peptides with an…”
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A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense by Van Arnam, Ethan B, Ruzzini, Antonio C, Sit, Clarissa S, Currie, Cameron R, Clardy, Jon

“…Bacterial symbionts of fungus-growing ants occupy a highly specialized ecological niche and face the constant existential threat of displacement by another…”
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Response of methicillin-resistant Staphylococcus aureus to amicoumacin A by Lama, Amrita, Pané-Farré, Jan, Chon, Tai, Wiersma, Anna M, Sit, Clarissa S, Vederas, John C, Hecker, Michael, Nakano, Michiko M

“…Amicoumacin A exhibits strong antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA), hence we sought to uncover its mechanism of…”
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Isolation of a Variant of Subtilosin A with Hemolytic Activity by TAI HUANG, HAO GENG, MIYYAPURAM, Venugopal R, SIT, Clarissa S, VEDERAS, John C, NAKANO, Michiko M

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2 by Gavrish, Ekaterina, Sit, Clarissa S, Cao, Shugeng, Kandror, Olga, Spoering, Amy, Peoples, Aaron, Ling, Losee, Fetterman, Ashley, Hughes, Dallas, Bissell, Anthony, Torrey, Heather, Akopian, Tatos, Mueller, Andreas, Epstein, Slava, Goldberg, Alfred, Clardy, Jon, Lewis, Kim

“…Languishing antibiotic discovery and flourishing antibiotic resistance have prompted the development of alternative untapped sources for antibiotic discovery,…”
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Selvamicin, an atypical antifungal polyene from two alternative genomic contexts by Van Arnam, Ethan B., Ruzzini, Antonio C., Sit, Clarissa S., Horn, Heidi, Pinto-Tomás, Adrián A., Currie, Cameron R., Clardy, Jon

“…The bacteria harbored by fungus-growing ants produce a variety of small molecules that help maintain a complex multilateral symbiosis. In a survey of…”
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De novo molecular drug design benchmarking by Grant, Lauren L., Sit, Clarissa S.

“…De novo molecular design for drug discovery is a growing field. Deep neural networks (DNNs) are becoming more widespread in their use for machine learning…”
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Insights into the Mechanism of Action of the Two-Peptide Lantibiotic Lacticin 3147 by Bakhtiary, Alireza, Cochrane, Stephen A, Mercier, Pascal, McKay, Ryan T, Miskolzie, Mark, Sit, Clarissa S, Vederas, John C

“…Lacticin 3147 is a two peptide lantibiotc (LtnA1 and LtnA2) that displays nanomolar activity against many Gram-positive bacteria. Lacticin 3147 may exert its…”
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Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates by Yoganathan, Sabesan, Sit, Clarissa S, Vederas, John C

“…The lantibiotic gallidermin was modified at lysine residues by regioselective attachment of derivatives of pyochelin, agrobactin and desferrioxamine B with the…”
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The 3D Solution Structure of Thurincin H, a Bacteriocin with Four Sulfur to α-Carbon Crosslinks by Sit, Clarissa S., van Belkum, Marco J., McKay, Ryan T., Worobo, Randy W., Vederas, John C.

“…Problem solved: Thurincin H is an antimicrobial peptide with suspected post‐translational modifications. MS/MS sequencing identified the residues that were…”
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The activity of bacteriocins from Carnobacterium maltaromaticum UAL307 against Gram-negative bacteria in combination with EDTA treatment by Martin-Visscher, Leah A., Yoganathan, Sabesan, Sit, Clarissa S., Lohans, Christopher T., Vederas, John C.

“…Abstract Bacteriocins from Gram-positive bacteria are potent antimicrobial peptides that inhibit pathogenic and food-spoilage bacteria. They are usually…”
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The 3D Structure of Thuricin CD, a Two-Component Bacteriocin with Cysteine Sulfur to α-Carbon Cross-links by Sit, Clarissa S, McKay, Ryan T, Hill, Colin, Ross, R. Paul, Vederas, John C

“…Thuricin CD is an antimicrobial factor that consists of two peptides, Trn-α and Trn-β, that exhibit synergistic activity against drug resistant strains of…”
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Structural Characterization of the Highly Cyclized Lantibiotic Paenicidin A via a Partial Desulfurization/Reduction Strategy by Lohans, Christopher T, Huang, Zedu, van Belkum, Marco J, Giroud, Maude, Sit, Clarissa S, Steels, Erika M, Zheng, Jing, Whittal, Randy M, McMullen, Lynn M, Vederas, John C

“…Lantibiotics are ribosomally synthesized antimicrobial peptides produced by bacteria that are increasingly of interest for food preservation and possible…”
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The Saccharomyces cerevisiae succinate dehydrogenase does not require heme for ubiquinone reduction by Oyedotun, Kayode S., Sit, Clarissa S., Lemire, Bernard D.

“…The coupling of succinate oxidation to the reduction of ubiquinone by succinate dehydrogenase (SDH) constitutes a pivotal reaction in the aerobic generation of…”
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Approaches to the discovery of new antibacterial agents based on bacteriocins by Sit, Clarissa S, Vederas, John C

“…The development of antibiotic resistance in pathogenic bacteria has led to a search for novel classes of antimicrobial drugs. Bacteriocins are peptides that…”
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Substitution of a Conserved Disulfide in the Type IIa Bacteriocin, Leucocin A, with L-Leucine and L-Serine Residues: Effects on Activity and Three-Dimensional Structure by Sit, Clarissa S., Lohans, Christopher T., van Belkum, Marco J., Campbell, Chantel D., Miskolzie, Mark, Vederas, John C.

“…Bridge not required: The disulfide bridge in the antibacterial peptide leucocin A was replaced with two Ser or two Leu residues. The double leucine mutant was…”
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Biochemical, Structural, and Genetic Characterization of Tridecaptin A1, an Antagonist of Campylobacter jejuni by Lohans, Christopher T., van Belkum, Marco J., Cochrane, Stephen A., Huang, Zedu, Sit, Clarissa S., McMullen, Lynn M., Vederas, John C.

“…Bacillus circulans NRRL B‐30644 (now Paenibacillus terrae) was previously reported to produce SRCAM 1580, a bacteriocin active against the food pathogen…”
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