Search Results - "Sistonen, L."

Heat-shock factor 2 is a suppressor of prostate cancer invasion by Björk, J K, Åkerfelt, M, Joutsen, J, Puustinen, M C, Cheng, F, Sistonen, L, Nees, M

“…Heat-shock factors (HSFs) are key transcriptional regulators in cell survival. Although HSF1 has been identified as a driver of carcinogenesis, HSF2 has not…”
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SUMO: getting it on by Anckar, J, Sistonen, L

“…Post-translational modification of cellular proteins by the SUMO (small ubiquitin-related modifier) is involved in numerous modes of regulation in widely…”
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Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression by Chang, Yunhua, Ostling, Päivi, Akerfelt, Malin, Trouillet, Diane, Rallu, Murielle, Gitton, Yorick, El Fatimy, Rachid, Fardeau, Vivienne, Le Crom, Stéphane, Morange, Michel, Sistonen, Lea, Mezger, Valérie

“…Heat-shock factors (HSFs) are associated with multiple developmental processes, but their mechanisms of action in these processes remain largely enigmatic…”
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Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis by Tran, S E F, Meinander, A, Holmström, T H, Rivero-Müller, A, Heiskanen, K M, Linnau, E K, Courtney, M J, Mosser, D D, Sistonen, L, Eriksson, J E

“…The heat shock response and death receptor-mediated apoptosis are both key physiological determinants of cell survival. We found that exposure to a mild heat…”
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Hsp70 Accumulation in Chondrocytic Cells Exposed to High Continuous Hydrostatic Pressure Coincides with mRNA Stabilization rather than Transcriptional Activation by Kaarniranta, K., Elo, M., Sironen, R., Lammi, M. J., Goldring, M. B., Eriksson, J. E., Sistonen, L., Helminen, H. J.

“…In response to various stress stimuli, heat shock genes are induced to express heat shock proteins (Hsps). Previous studies have revealed that expression of…”
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Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription by SISTONEN, L, SARGE, K. D, MORIMOTO, R. I

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Effects of heat shock and hypoxia on protein synthesis in rainbow trout (Oncorhynchus mykiss) cells by Airaksinen, S, Råbergh, C M, Sistonen, L, Nikinmaa, M

“…We examined the effects of heat stress (from 18 degreesC to 26 degreesC) and low oxygen tension (1% O2=1 kPa) on protein synthesis in primary cultures of…”
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Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells by SISTONEN, L, SARGE, K. D, PHILLIPS, B, ABRAVAYA, K, MORIMOTO, R. I

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Arachidonate is a Potent Modulator of Human Heat Shock Gene Transcription by Jurivich, Donald A., Sistonen, Lea, Sarge, Kevin D., Morimoto, Richard I.

“…Cell and tissue injury activate the inflammatory response through the action(s) of arachidonic acid and its metabolites, leading to the expression of…”
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Heat shock factor 2 is activated during mouse heart development by Eriksson, M, Jokinen, E, Sistonen, L, Leppä, S

“…Two members of the heat shock transcription factor family, HSF1 and HSF2, have been identified as activators of mammalian heat shock gene expression. HSF1 acts…”
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Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation by PERTOVAARA, L, SISTONEN, L, BOS, T. J, VOGT, P. K, KESKI-OJA, J, ALITALO, K

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667 APC/C plays a role in the acute response to protein-damaging stress by Roos-Mattjus, P, Ahlskog, J.K, Björk, J.K, Elsing, A.N, Kallio, M, Sistonen, L

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Antiproliferative Prostaglandins Activate Heat Shock Transcription Factor by Amici, Carla, Sistonen, Lea, Santoro, M. Gabriella, Morimoto, Richard I.

“…Treatment of human K562 erythroleukemia cells with the antiproliferative prostaglandin A1results in the elevated transcription of two heat shock genes, HSP70…”
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Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response by Kaarniranta, K., Holmberg, C.I., Lammi, M.J., Eriksson, J.E., Sistonen, L., Helminen, H.J.

“…Objective During joint loading, chondrocytes in the articular cartilage are subjected to gradients of high compressive hydrostatic pressure (HP). In response…”
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The mechanisms of ornithine decarboxylase deregulation in c-Ha-ras oncogene-transformed NIH 3T3 cells by Hölttä, E, Sistonen, L, Alitalo, K

“…NIH 3T3 cells transformed with the human c-Ha-rasVal-12 oncogene showed markedly enhanced activity of ornithine decarboxylase (ODC), the key enzyme of…”
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HSFs drive transcription of distinct genes and enhancers during oxidative stress and heat shock by Himanen, Samu V, Puustinen, Mikael C, Da Silva, Alejandro J, Vihervaara, Anniina, Sistonen, Lea

“…Reprogramming of transcription is critical for the survival under cellular stress. Heat shock has provided an excellent model to investigate nascent…”
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Heat Shock Factors at a Crossroad between Stress and Development by ÅKERFELT, MALIN, TROUILLET, DIANE, MEZGER, VALÉRIE, SISTONEN, LEA

“…:  Organisms must be able to sense and respond rapidly to changes in their environment in order to maintain homeostasis and survive. Induction of heat shock…”
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Stress induction of the mammalian GRP78/BiP protein gene: in vivo genomic footprinting and identification of p70CORE from human nuclear extract as a DNA-binding component specific to the stress regulatory element by Li, W W, Sistonen, L, Morimoto, R I, Lee, A S

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Deficient Induction of Human hsp70 Heat Shock Gene Transcription in Y79 Retinoblastoma Cells Despite Activation of Heat Shock Factor 1 by Mathur, Sameer K., Sistonen, Lea, Brown, Ian R., Murphy, Shawn P., Sarge, Kevin D., Morimoto, Richard I.

“…One of the basic features of the inducible heat shock response is the activation of heat shock factor which results in the rapid transcriptional induction of…”
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Roles of the heat shock transcription factors in regulation of the heat shock response and beyond by PIRKKALA, LILA, NYKÄNEN, PÄIVI, SISTONEN, LEA

“…ABSTRACT The heat shock response, characterized by increased expression of heat shock proteins (Hsps) is induced by exposure of cells and tissues to extreme…”
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