Search Results - "Sissy, Carine El"

Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients by Kirilovsky, Amos, Marliot, Florence, El Sissy, Carine, Haicheur, Nacilla, Galon, Jérôme, Pagès, Franck

“…The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) tumor, nodes, metastasis (TNM) classification system based on tumor…”
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A Diagnostic Biopsy-Adapted Immunoscore Predicts Response to Neoadjuvant Treatment and Selects Patients with Rectal Cancer Eligible for a Watch-and-Wait Strategy by El Sissy, Carine, Kirilovsky, Amos, Van den Eynde, Marc, Muşină, Ana-Maria, Anitei, Maria-Gabriela, Romero, Alfredo, Marliot, Florence, Junca, Audelaure, Doyen, Jérôme, Mlecnik, Bernhard, Haicheur, Nacilla, Fredriksen, Tessa, Lagorce, Christine, Jouret-Mourin, Anne, Leonard, Daniel, Bibeau, Frédéric, Iseas, Soledad, Roca, Enrique L, Cabanne, Ana M, Vaccaro, Carlos A, Santino, Juan P, Huertas, Eduardo, Tougeron, David, Carvalho, Carlos, Figueiredo, Nuno, Perez, Rodrigo O, Habr-Gama, Angelita, Scripcariu, Viorel, Gerard, Jean-Pierre, Galon, Jérôme, Zeitoun, Guy, Pagès, Franck

“…No biomarker to personalize treatment in locally advanced rectal cancer (LARC) is currently available. We assessed in LARC whether a diagnostic biopsy-adapted…”
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Results of transvenous embolization of intracranial dural arteriovenous fistula: a consecutive series of 136 patients with 142 fistulas by Guédon, Alexis, Saint-Maurice, Jean-Pierre, Thépenier, Cédric, Labeyrie, Marc-Antoine, Civelli, Vittorio, Sissy, Carine El, Eliezer, Michael, Aymard, Armand, Guichard, Jean-Pierre, Houdart, Emmanuel

“…Intracranial dural arteriovenous fistula (DAVF) is mainly treated with an endovascular approach. Two major treatment advances include transvenous embolization…”
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Therapeutic Implications of the Immunoscore in Patients with Colorectal Cancer by El Sissy, Carine, Kirilovsky, Amos, Zeitoun, Guy, Marliot, Florence, Haicheur, Nacilla, Lagorce-Pagès, Christine, Galon, Jérôme, Pagès, Franck

“…Four decades were needed to progress from the first demonstration of the independent prognostic value of lymphocytes infiltration in rectal cancers to the…”
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Clinical and Genetic Spectrum of a Large Cohort With Total and Sub-total Complement Deficiencies by El Sissy, Carine, Rosain, Jérémie, Vieira-Martins, Paula, Bordereau, Pauline, Gruber, Aurélia, Devriese, Magali, de Pontual, Loïc, Taha, Muhamed-Kheir, Fieschi, Claire, Picard, Capucine, Frémeaux-Bacchi, Véronique

“…The complement system is crucial for defense against pathogens and the removal of dying cells or immune complexes. Thus, clinical indications for possible…”
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Strains Responsible for Invasive Meningococcal Disease in Patients With Terminal Complement Pathway Deficiencies by Rosain, Jérémie, Hong, Eva, Fieschi, Claire, Martins, Paula, Sissy, Carine El, Deghmane, Ala-Eddine, Ouachée, Marie, Thomas, Caroline, Launay, David, de Pontual, Loïc, Suarez, Felipe, Moshous, Despina, Picard, Capucine, Taha, Muhamed-Kheir, Frémeaux-Bacchi, Véronique

“…Background. Patients with terminal complement pathway deficiency (TPD) are susceptible to recurrent invasive meningococcal disease (IMD). Neisseria…”
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Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System by Pedersen, Dennis V, Gadeberg, Trine A F, Thomas, Caroline, Wang, Yong, Joram, Nicolas, Jensen, Rasmus K, Mazarakis, Sofia M M, Revel, Margot, El Sissy, Carine, Petersen, Steen V, Lindorff-Larsen, Kresten, Thiel, Steffen, Laursen, Nick S, Fremeaux-Bacchi, Véronique, Andersen, Gregers R

“…Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative…”
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Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity by Dragon-Durey, Marie-Agnès, Chen, Xiaoyi, Kirilovsky, Amos, Ben Hamouda, Nadine, El Sissy, Carine, Russick, Jules, Charpentier, Etienne, Binois, Yannick, Marliot, Florence, Meylan, Maxime, Granier, Clémence, Pere, Hélène, Saldmann, Antonin, Rance, Bastien, Jannot, Anne Sophie, Baron, Stéphanie, Chebbi, Mouna, Fayol, Antoine, Josseaume, Nathalie, Rives-Lange, Claire, Tharaux, Pierre-Louis, Cholley, Bernard, Diehl, Jean-Luc, Arlet, Jean-Benoît, Azizi, Michel, Karras, Alexandre, Czernichow, Sébastien, Smadja, David M, Hulot, Jean-Sébastien, Cremer, Isabelle, Tartour, Eric, Mousseaux, Elie, Pagès, Franck

“…To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients…”
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Acquired Flucytosine Resistance during Combination Therapy with Caspofungin and Flucytosine for Candida glabrata Cystitis by Charlier, Caroline, El Sissy, Carine, Bachelier-Bassi, Sophie, Scemla, Anne, Quesne, Gilles, Sitterlé, Emilie, Legendre, Christophe, Lortholary, Olivier, Bougnoux, Marie-Elisabeth

“…Treatment of Candida glabrata cystitis remains a therapeutic challenge, and an antifungal combination using flucytosine is one option. We describe two patients…”
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The "Immunoscore" in rectal cancer: could we search quality beyond quantity of life? by Kirilovsky, Amos, Sissy, Carine El, Zeitoun, Guy, Marliot, Florence, Haicheur, Nacilla, Lagorce-Pagès, Christine, Taieb, Julien, Karoui, Mehdi, Custers, Petra, Dizdarevic, Edina, Iseas, Soledad, Hansen, Torben Frøstrup, Jensen, Lars Henrik, Beets, Geerard, Gérard, Jean Pierre, Castillo-Martin, Mireia, Figueiredo, Nuno, Habr-Gama, Angelita, Perez, Rodrigo, Galon, Jérôme, Pagès, Franck

“…Because of the function and anatomical environment of the rectum, therapeutic strategies for local advanced rectal cancer (LARC) must deal with two challenging…”
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Analytical validation of the Immunoscore and its associated prognostic value in patients with colon cancer by Marliot, Florence, Chen, Xiaoyi, Kirilovsky, Amos, Sbarrato, Thomas, El Sissy, Carine, Batista, Luciana, Van den Eynde, Marc, Haicheur-Adjouri, Nacilla, Anitei, Maria-Gabriela, Musina, Ana-Maria, Scripcariu, Viorel, Lagorce-Pagès, Christine, Hermitte, Fabienne, Galon, Jérôme, Fieschi, Jacques, Pagès, Franck

“…BackgroundNew and fully validated tests need to be brought into clinical practice to improve the estimation of recurrence risk in patients with colon cancer…”
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Defining the genetics of thrombotic microangiopathies by Vieira-Martins, Paula, El Sissy, Carine, Bordereau, Pauline, Gruber, Aurelia, Rosain, Jeremie, Fremeaux-Bacchi, Veronique

“…Abstract The spectrum of the thrombotic microangiopathies (TMA) encompasses a heterogeneous group of disorders with hereditary and acquired forms. Endothelial…”
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Multi-Institutional Evaluation of Pathologists’ Assessment Compared to Immunoscore by Willis, Joseph, Anders, Robert A, Torigoe, Toshihiko, Hirohashi, Yoshihiko, Bifulco, Carlo, Zlobec, Inti, Mlecnik, Bernhard, Demaria, Sandra, Choi, Won-Tak, Dundr, Pavel, Tatangelo, Fabiana, Di Mauro, Annabella, Baldin, Pamela, Bindea, Gabriela, Marliot, Florence, Haicheur, Nacilla, Fredriksen, Tessa, Kirilovsky, Amos, Buttard, Bénédicte, Vasaturo, Angela, Lafontaine, Lucie, Maby, Pauline, El Sissy, Carine, Hijazi, Assia, Majdi, Amine, Lagorce, Christine, Berger, Anne, Van den Eynde, Marc, Pagès, Franck, Lugli, Alessandro, Galon, Jérôme

“…Background: The Immunoscore (IS) is a quantitative digital pathology assay that evaluates the immune response in cancer patients. This study reports on the…”
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C3 glomerulopathy is highly prevalent in French Polynesia by Candela, Nelly, Benichou, Nicolas, Lefebvre, Mathilde, Gueguen, Lorraine, Vieira-Martins, Paula, El Sissy, Carine, Sartelet, Hervé, Testevuide, Pascale, Delaval, Ronan, Faguer, Stanislas

“…To compare the natural history of C3 glomerulopathy (C3G) to acute post-infectious glomerulonephritis (APIGN) in a cohort of patients with a relative…”
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Increased levels of GM-CSF and CXCL10 and low CD8 + memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people by Poisson, Johanne, El-Sissy, Carine, Serret-Larmande, Arnaud, Smith, Nikaïa, Lebraud, Morgane, Augy, Jean-Loup, Conti, Catherine, Gonnin, Cécile, Planquette, Benjamin, Arlet, Jean-Benoît, Hermann, Bertrand, Charbit, Bruno, Pastre, Jean, Devaux, Floriane, Ladavière, Cyrielle, Lim, Lydie, Ober, Pauline, Cannovas, Johanna, Biard, Lucie, Gulczynski, Marie-Christelle, Blumenthal, Noémie, Péré, Hélène, Knosp, Camille, Gey, Alain, Benhamouda, Nadine, Murris, Juliette, Veyer, David, Tartour, Eric, Diehl, Jean-Luc, Duffy, Darragh, Paillaud, Elena, Granier, Clémence

“…Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process…”
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Immune Signature Linked to COVID-19 Severity: A SARS-Score for Personalized Medicine by Russick, Jules, Foy, Pierre-Emmanuel, Josseaume, Nathalie, Meylan, Maxime, Hamouda, Nadine Ben, Kirilovsky, Amos, Sissy, Carine El, Tartour, Eric, Smadja, David M., Karras, Alexandre, Hulot, Jean-Sébastien, Livrozet, Marine, Fayol, Antoine, Arlet, Jean-Benoit, Diehl, Jean-Luc, Dragon-Durey, Marie-Agnès, Pagès, Franck, Cremer, Isabelle

“…SARS-CoV-2 infection leads to a highly variable clinical evolution, ranging from asymptomatic to severe disease with acute respiratory distress syndrome,…”
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P392: Rapid complement mediated TMA diagnosis and early intervention in a renal intensive care unit using Nanopore technology by Yousfi, Nadhi, Mousseaux, Cyril, Mile, Marie, Hamza, Abderaouf, Rafat, Cedric, Luque, Yosu, El sissy, Carine, Beaumeunier, Sacha, Bertrand, Denis, Blum, Michael, Doudement, Julien, Philippe, Nicolas, Fremeaux-Bacchi, Veronique, Mesnard, Laurent

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Chemoradiation triggers antitumor Th1 and tissue resident memory-polarized immune responses to improve immune checkpoint inhibitors therapy by Lauret Marie Joseph, Elodie, Kirilovsky, Amos, Lecoester, Benoît, El Sissy, Carine, Boullerot, Laura, Rangan, Laurie, Marguier, Amélie, Tochet, Florent, Dosset, Magalie, Boustani, Jihane, Ravel, Patrice, Boidot, Romain, Spehner, Laurie, Haicheur-Adjouri, Nacilla, Marliot, Florence, Pallandre, Jean-René, Bonnefoy, Francis, Scripcariu, Viorel, Van den Eynde, Marc, Cornillot, Emmanuel, Mirjolet, Céline, Pages, Franck, Adotevi, Olivier

“…BackgroundMultiple synergistic combination approaches with cancer drugs are developed to overcome primary resistance to immunotherapy; however, the mechanistic…”
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Impact of PD-L1 Scores and Changes on Clinical Outcome in Rectal Cancer Patients Undergoing Neoadjuvant Chemoradiotherapy by Huemer, Florian, Klieser, Eckhard, Neureiter, Daniel, Schlintl, Verena, Rinnerthaler, Gabriel, Pagès, Franck, Kirilovsky, Amos, El Sissy, Carine, Iglseder, Wolfgang, Singhartinger, Franz, Jäger, Tarkan, Dinnewitzer, Adam, Zaborsky, Nadja, Steiner, Markus, Greil, Richard, Weiss, Lukas

“…Reports on the prognostic role of programmed death-ligand 1 (PD-L1) expression in rectal cancer are controversial. We investigated expression patterns and…”
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The Immunoscore in the Clinical Practice of Patients with Colon and Rectal Cancers by Zeitoun, Guy, Sissy, Carine El, Kirilovsky, Amos, Anitei, Gabriela, Todosi, Anna-Maria, Marliot, Florence, Haicheur, Nacilla, Lagorce, Christine, Berger, Anne, Zinzindohoué, Franck, Galon, Jérome, Scripcariu, Viorel, Pagès, Franck

“…In the fine balance between tumor invasion and our defensive systems, the role played by the adaptive immune response at the tumor site is critical. Beyond the…”
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