Search Results - "Sisodiya, Sanjay M"

Comorbidities of epilepsy: current concepts and future perspectives by Keezer, Mark R, MDCM, Sisodiya, Sanjay M, Prof, Sander, Josemir W, Prof

“…Summary The burden of comorbidity in people with epilepsy is high. Several diseases, including depression, anxiety, dementia, migraine, heart disease, peptic…”
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Advances in the development of biomarkers for epilepsy by Pitkänen, Asla, Prof, Löscher, Wolfgang, Prof, Vezzani, Annamaria, Prof, Becker, Albert J, Prof, Simonato, Michele, Prof, Lukasiuk, Katarzyna, Prof, Gröhn, Olli, Prof, Bankstahl, Jens P, PhD, Friedman, Alon, Prof, Aronica, Eleonora, Prof, Gorter, Jan A, Prof, Ravizza, Teresa, PhD, Sisodiya, Sanjay M, Prof, Kokaia, Merab, Prof, Beck, Heinz, Prof

“…Summary Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy remains unsatisfactorily controlled despite the availability of…”
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Structural imaging biomarkers of sudden unexpected death in epilepsy by Wandschneider, Britta, Koepp, Matthias, Scott, Catherine, Micallef, Caroline, Balestrini, Simona, Sisodiya, Sanjay M, Thom, Maria, Harper, Ronald M, Sander, Josemir W, Vos, Sjoerd B, Duncan, John S, Lhatoo, Samden, Diehl, Beate

“…Sudden unexpected death in epilepsy is a major cause of premature death in people with epilepsy. We aimed to assess whether structural changes potentially…”
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Treatment of Epileptic Encephalopathies by Balestrini, Simona, Sisodiya, Sanjay M

“…Epileptic encephalopathies represent the most severe epilepsies, with onset in infancy and childhood and seizures continuing in adulthood in most cases. New…”
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Neuropathology of the blood―brain barrier and pharmaco-resistance in human epilepsy by LIU, Joan Y. W, THORN, Maria, CATARINO, Claudia B, MARTINIAN, Lillian, FIGARELLA-BRANGER, Dominique, BARTOLOMEI, Fabrice, KOEPP, Matthias, SISODIYA, Sanjay M

“…Blood-brain barrier dysfunction is implicated in various neurological conditions. Modulating the blood-brain barrier may have therapeutic value. Progress is…”
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The impact of SARS-CoV-2 vaccination in Dravet syndrome: A UK survey by Clayton, Lisa M., Balestrini, Simona, Cross, J. Helen, Wilson, Galia, Eldred, Claire, Evans, Helen, Koepp, Matthias J., Sisodiya, Sanjay M.

“…•Caregivers are concerned about SARS-CoV-2 vaccines in people with Dravet syndrome.•Severe acute respiratory syndrome coronavirus 2 vaccines are safe and well…”
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Valproate Use Is Associated With Posterior Cortical Thinning and Ventricular Enlargement in Epilepsy Patients by Tondelli, Manuela, Vaudano, Anna Elisabetta, Sisodiya, Sanjay M., Meletti, Stefano

“…Valproate is a drug widely used to treat epilepsy, bipolar disorder, and occasionally to prevent migraine headache. Despite its clinical efficacy, prenatal…”
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P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study by Feldmann, Maria, MD, Asselin, Marie-Claude, PhD, Liu, Joan, PhD, Wang, Shaonan, PhD, McMahon, Adam, PhD, Anton-Rodriguez, José, PhD, Walker, Matthew, PhD, Symms, Mark, PhD, Brown, Gavin, PhD, Hinz, Rainer, PhD, Matthews, Julian, PhD, Bauer, Martin, MD, Langer, Oliver, PhD, Thom, Maria, PhD, Jones, Terry, Prof, Vollmar, Christian, MD, Duncan, John S, Prof, Sisodiya, Sanjay M, Prof, Koepp, Matthias J, Prof

“…Summary Background Studies in rodent models of epilepsy suggest that multidrug efflux transporters at the blood–brain barrier, such as P-glycoprotein, might…”
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Precision medicine and therapies of the future by Sisodiya, Sanjay M.

“…Precision medicine in the epilepsies has gathered much attention, especially with gene discovery pushing forward new understanding of disease biology. Several…”
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Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia by Poole, Josephine, Zagaglia, Sara, Demurtas, Rita, Farrell, Fiona, Walker, Matthew C, Sisodiya, Sanjay M, Balestrini, Simona, Vivekananda, Umesh

“…Alternating Hemiplegia of Childhood (AHC) is characterised by paroxysmal hemiplegic episodes and seizures. Remission of hemiplegia upon sleep is a clinical…”
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P‐glycoprotein overactivity in epileptogenic developmental lesions measured in vivo using (R)‐[11C]verapamil PET by Ilyas‐Feldmann, Maria, Asselin, Marie‐Claude, Wang, Shaonan, McMahon, Adam, Anton‐Rodriguez, José, Brown, Gavin, Hinz, Rainer, Duncan, John S., Sisodiya, Sanjay M., Koepp, Matthias

“…Objective Overexpression of the drug transporter P‐glycoprotein (P‐gp) is thought to be involved in drug‐resistance in epilepsy by extrusion of antiepileptic…”
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Focal cortical dysplasia type II: biological features and clinical perspectives by Sisodiya, Sanjay M, FRCP, Fauser, Susanne, MD, Cross, J Helen, FRCP, Thom, Maria, FRCPath

“…Summary Focal cortical dysplasia (FCD) type II is an important cause of drug-resistant epilepsy. Clinical presentation is variable, and depends on age of onset…”
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Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options by Löscher, Wolfgang, Potschka, Heidrun, Sisodiya, Sanjay M., Vezzani, Annamaria

“…Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide. Despite the availability of over 20 antiseizure drugs (ASDs) for…”
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Malformations of cortical development: burdens and insights from important causes of human epilepsy by Sisodiya, Sanjay M

“…Malformations of cortical development (MCD) are important causes of chronic epilepsy in human beings. A blanket term, MCD encompasses many varied developmental…”
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A quantitative study of white matter hypomyelination and oligodendroglial maturation in focal cortical dysplasia type II by Shepherd, Caterina, Liu, Joan, Goc, Joanna, Martinian, Lillian, Jacques, Thomas S., Sisodiya, Sanjay M., Thom, Maria

“…Summary Purpose A diagnostic feature of focal cortical dysplasia (FCD) type II on magnetic resonance imaging (MRI) is increased subcortical white matter (WM)…”
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Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics Investigation of Neurodevelopmental Migratory Pathways by Liu, Joan Y W, Dzurova, Natasha, Al-Kaaby, Batoul, Mills, Kevin, Sisodiya, Sanjay M, Thom, Maria

“…Granule cell dispersion (GCD) is a common pathological feature observed in the hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE)…”
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Genome annotation for clinical genomic diagnostics: strengths and weaknesses by Steward, Charles A, Parker, Alasdair P J, Minassian, Berge A, Sisodiya, Sanjay M, Frankish, Adam, Harrow, Jennifer

“…The Human Genome Project and advances in DNA sequencing technologies have revolutionized the identification of genetic disorders through the use of clinical…”
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Pharmacogenomics in epilepsy by Balestrini, Simona, Sisodiya, Sanjay M.

“…•Genetic variation can influence response to antiepileptic drug (AED) treatment through various effector processes.•Metabolism of many AEDs is mediated by the…”
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Climate change and neurology: time to talk and to act by Sisodiya, Sanjay M

“…The Lancet Countdown has already reported on the serious current and projected consequences of climate change on population health, as related at the meeting…”
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SCN1A testing for epilepsy: Application in clinical practice by Hirose, Shinichi, Scheffer, Ingrid E., Marini, Carla, Jonghe, Peter, Andermann, Eva, Goldman, Alica M., Kauffman, Marcelo, Tan, Nigel C. K., Lowenstein, Daniel H., Sisodiya, Sanjay M., Ottman, Ruth, Berkovic, Samuel F.

“…Summary This report is a practical reference guide for genetic testing of SCN1A, the gene encoding the α1 subunit of neuronal voltage‐gated sodium channels…”
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