Search Results - "Sisko Patana, Anne"

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  1. 1
    Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics

    Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics by Zhang, Hongbo, Patana, Anne-Sisko, Mackenzie, Peter I, Ikushiro, Shinichi, Goldman, Adrian, Finel, Moshe

    Published in Drug metabolism and disposition (01-10-2012)
    “…Many laboratories use recombinant UDP-glucuronosyltransferases (UGTs), expressed in baculovirus-infected insect cells, for drug glucuronidation studies. We…”
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  2. 2
    Inducement and blocking mechanisms in the Finnish life sciences innovation system

    Inducement and blocking mechanisms in the Finnish life sciences innovation system by Sisko Patana, Anne, Pihlajamaa, Matti, Polvinen, Kirsi, Carleton, Tamara, Kanto, Laura

    Published in Foresight (Cambridge) (11-11-2013)
    “…Purpose – This paper aims to identify inducement and blocking mechanisms which impact the development of the life sciences innovation system in Finland…”
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  3. 3
    The human UDP-glucuronosyltransferase: identification of key residues within the nucleotide-sugar binding site

    The human UDP-glucuronosyltransferase: identification of key residues within the nucleotide-sugar binding site by Patana, Anne-Sisko, Kurkela, Mika, Goldman, Adrian, Finel, Moshe

    Published in Molecular pharmacology (01-09-2007)
    “…UDP-glucuronosyltransferases (UGTs) play important roles in the metabolism, detoxification,and clearance of many different xenobiotics, including drugs and…”
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  4. 4
    The First Aspartic Acid of the DQxD Motif for Human UDP-Glucuronosyltransferase 1A10 Interacts with UDP-Glucuronic Acid during Catalysis

    The First Aspartic Acid of the DQxD Motif for Human UDP-Glucuronosyltransferase 1A10 Interacts with UDP-Glucuronic Acid during Catalysis by Xiong, Yan, Patana, Anne-Sisko, Miley, Michael J, Zielinska, Agnieszka K, Bratton, Stacie M, Miller, Grover P, Goldman, Adrian, Finel, Moshe, Redinbo, Matt R, Radominska-Pandya, Anna

    Published in Drug metabolism and disposition (01-03-2008)
    “…All UDP-glucuronosyltransferase enzymes (UGTs) share a common cofactor, UDP-glucuronic acid (UDP-GlcUA). The binding site for UDP-GlcUA is localized to the…”
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  5. 5
    Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6

    Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6 by Kurkela, Mika, Patana, Anne-Sisko, Mackenzie, Peter I, Court, Michael H, Tate, Christopher G, Hirvonen, Jouni, Goldman, Adrian, Finel, Moshe

    Published in Pharmacogenetics and genomics (01-02-2007)
    “…OBJECTIVESTo explore the possible role of hetero-oligomerization among the human UDP-glucuronosyltransferases in attenuating the consequences of the…”
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  6. 6
    Mutation analysis in UGT1A9 suggests a relationship between substrate and catalytic residues in UDP-glucuronosyltransferases

    Mutation analysis in UGT1A9 suggests a relationship between substrate and catalytic residues in UDP-glucuronosyltransferases by Patana, Anne-Sisko, Kurkela, Mika, Finel, Moshe, Goldman, Adrian

    Published in Protein engineering, design and selection (01-09-2008)
    “…UDP-glucuronosyltransferases (UGTs) catalyze the transfer of glucuronic acid from UDP-glucuronic acid to endo- and xenobiotics in our body. UGTs belong to the…”
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  7. 7
    Comparative characterization of UDP‐glucuronic acid (UDP‐GlcUA) binding‐site directed inhibitors with human UGT2B7 and 1A10

    Comparative characterization of UDP‐glucuronic acid (UDP‐GlcUA) binding‐site directed inhibitors with human UGT2B7 and 1A10 by Bratton, Stacie Moseley, Laakkonen, Liisa, Patana, Anne‐Sisko, Mazur, Anna, Miller, Grover P., Finel, Moshe, Radominska‐Pandya, Anna

    Published in The FASEB journal (01-04-2009)
    “…Abstract only Recent crystallography, homology modeling, and mutagenesis studies of human UGTs have demonstrated that UGT2B7 and 1A10 possess a number of…”
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  8. 8
    Qualitative evaluation of the finnish life science innovation system with comparison to the San Francisco Bay Area

    Qualitative evaluation of the finnish life science innovation system with comparison to the San Francisco Bay Area by Patana, Anne-Sisko, Pihlajamaa, Matti, Polvinen, Kirsi, Carleton, Tamara, Kanto, Laura

    “…The life science sector is among the fastest growing knowledge fields characterized by a high rate of radical innovations. However, it does not have a long…”
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