Search Results - "Sisko, Jack"

Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position by Tucker, Thomas J, Brady, Stephen F, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Naylor-Olsen, Adel M, Yan, Youwei, Sisko, Jack T, Stauffer, Kenneth J, Lucas, Bobby J, Lynch, Joseph J, Cook, Jacquelynn J, Stranieri, Maria T, Holahan, Marie A, Lyle, Elizabeth A, Baskin, Elizabeth P, Chen, I-Wu, Dancheck, Kimberly B, Krueger, Julie A, Cooper, Carolyn M, Vacca, Joseph P

“…As part of an ongoing effort to prepare therapeutically useful orally active thrombin inhibitors, we have synthesized a series of compounds that utilize…”
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A Sulfur-Controlled Approach to the Synthesis of Linerixibat by Barcan, Gregg A., Kwon, Doo-Hyun, Guo, Jiasheng, Kowalski, John A., Liu, Li, Nilson, Mark, Sisko, Jack, Wang, Huan, Brown, Timothy A., Gholipour-Ranjbar, Habib

“…Establishing the two stereocenters in the benzothiazepine ring of linerixibat (GSK2330672) has been a long-standing problem at GSK. Our solution rests on an…”
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Synthesis of a Series of Potent and Orally Bioavailable Thrombin Inhibitors That Utilize 3,3-Disubstituted Propionic Acid Derivatives in the P3 Position by Tucker, Thomas J, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Lucas, Bobby J, Sisko, Jack T, Lynch, Joseph J, Lyle, Elizabeth A, Baskin, Elizabeth P, Woltmann, Richard F, Appleby, Sandra D, Chen, I-Wu, Dancheck, Kimberley B, Naylor-Olsen, Adel M, Krueger, Julie A, Cooper, Carolyn M, Vacca, Joseph P

“…As part of an effort to prepare efficacious and orally bioavailable analogs of the previously reported thrombin inhibitors 1a,b, we have synthesized a series…”
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Synthesis of a Series of Potent and Orally Bioavailable Thrombin Inhibitors That Utilize 3,3-Disubstituted Propionic Acid Derivatives in the P 3 Position by Tucker, Thomas J., Lumma, William C., Lewis, S. Dale, Gardell, Stephen J., Lucas, Bobby J., Sisko, Jack T., Lynch, Joseph J., Lyle, Elizabeth A., Baskin, Elizabeth P., Woltmann, Richard F., Appleby, Sandra D., Chen, I-Wu, Dancheck, Kimberley B., Naylor-Olsen, Adel M., Krueger, Julie A., Cooper, Carolyn M., Vacca, Joseph P.

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