Search Results - "Sishc, Brock"

The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer by Sishc, Brock J, Davis, Anthony J

“…DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are misrepaired, potentially result in chromosomal aberrations, known…”
Get full text

Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair by Mohamad, Osama, Sishc, Brock J, Saha, Janapriya, Pompos, Arnold, Rahimi, Asal, Story, Michael D, Davis, Anthony J, Kim, D W Nathan

“…Compared to conventional photon-based external beam radiation (PhXRT), carbon ion radiotherapy (CIRT) has superior dose distribution, higher linear energy…”
Get full text

Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide by Sishc, Brock J, Ding, Lianghao, Nam, Taek-Keun, Heer, Collin D, Rodman, Samuel N, Schoenfeld, Joshua D, Fath, Melissa A, Saha, Debabrata, Pulliam, Casey F, Langen, Britta, Beardsley, Robert A, Riley, Dennis P, Keene, Jeffery L, Spitz, Douglas R, Story, Michael D

“…Avasopasem manganese (AVA or GC4419), a selective superoxide dismutase mimetic, is in a phase 3 clinical trial (NCT03689712) as a mitigator of…”
Get more information

Current trends and future perspectives in hadron therapy: radiobiology by Story, Michael D., Davis, Anthony J., Sishc, Brock J.

“…Purpose The purpose of this article was to highlight current and future trends in radiobiology in an effort to move hadron therapy forward through the…”
Get full text

Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability by CHERNIKOVA, Sophia B, RAZORENOVA, Olga V, GAME, John C, BROWN, J. Martin, HIGGINS, John P, SISHC, Brock J, NICOLAU, Monica, DORTH, Jennifer A, CHERNIKOVA, Diana A, KWOK, Shirley, BROOKS, James D, BAILEY, Susan M

“…Mammalian Bre1 complexes (BRE1A/B (RNF20/40) in humans and Bre1a/b (Rnf20/40) in mice) function similarly to their yeast homolog Bre1 as ubiquitin ligases in…”
Get full text

DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe by Ashley, Amanda K., Shrivastav, Meena, Nie, Jingyi, Amerin, Courtney, Troksa, Kyle, Glanzer, Jason G., Liu, Shengqin, Opiyo, Stephen O., Dimitrova, Diana D., Le, Phuong, Sishc, Brock, Bailey, Susan M., Oakley, Greg G., Nickoloff, Jac A.

“…•We demonstrate a critical role for DNA-PK in cell responses to replication stress.•DNA-PK is the primary kinase targeting RPA32 Ser4/Ser8.•RPA32…”
Get full text

The Need for Biological Countermeasures to Mitigate the Risk of Space Radiation-Induced Carcinogenesis, Cardiovascular Disease, and Central Nervous System Deficiencies by Sishc, Brock J., Zawaski, Janice, Saha, Janapriya, Carnell, Lisa S., Fabre, Kristin M., Elgart, S. Robin

“…NASA's currently planned long-duration, deep space exploration missions outside of low Earth orbit (LEO) will result in the exposure of astronauts to…”
Get full text

Breaking the limit: Biological countermeasures for space radiation exposure to enable long-duration spaceflight by Dynan, William S., Chang, Polly Y., Sishc, Brock J., Elgart, S.Robin

“…•Radiation medical countermeasures afford a strategy to address the difference between permissible and actual radiation exposures for deep space missions.•The…”
Get full text

Evaluation of the Response of HNSCC Cell Lines to γ-Rays and 12C Ions: Can Radioresistant Tumors Be Identified and Selected for 12C Ion Radiotherapy? by Ding, Lianghao, Sishc, Brock J., Polsdofer, Elizabeth, Yordy, John S., Facoetti, Angelica, Ciocca, Mario, Saha, Debabrata, Pompos, Arnold, Davis, Anthony J., Story, Michael D.

“…Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Thirty percent of patients will experience locoregional recurrence…”
Get full text

Radiation-Induced Reprogramming of Pre-Senescent Mammary Epithelial Cells Enriches Putative CD44(+)/CD24(-/low) Stem Cell Phenotype by Gao, Xuefeng, Sishc, Brock J, Nelson, Christopher B, Hahnfeldt, Philip, Bailey, Susan M, Hlatky, Lynn

“…The enrichment of putative CD44(+)/CD24(-/low) breast stem cell populations following exposure to ionizing radiation (IR) has been ascribed to their inherent…”
Get full text

Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis by Sishc, Brock J, Nelson, Christopher B, McKenna, Miles J, Battaglia, Christine L R, Herndon, Andrea, Idate, Rupa, Liber, Howard L, Bailey, Susan M

“…Telomeres are nucleoprotein complexes comprised of tandem arrays of repetitive DNA sequence that serve to protect chromosomal termini from inappropriate…”
Get full text

Radiation-Induced Reprogramming of Pre-Senescent Mammary Epithelial Cells Enriches Putative CD44+/CD24−/low Stem Cell Phenotype by Gao, Xuefeng, Sishc, Brock J., Nelson, Christopher B., Hahnfeldt, Philip, Bailey, Susan M., Hlatky, Lynn

“…The enrichment of putative CD44 + /CD24 −/low breast stem cell populations following exposure to ionizing radiation (IR) has been ascribed to their inherent…”
Get full text

Abstract C52: The radioprotector GC4419 enhances the response of PDAC tumors to high dose per fraction radiation exposure by Story, Michael D., Sishc, Brock J.

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the United States, with an estimated 5-year overall…”
Get full text

Abstract 6284: GC4419 protects again radiation induced oral mucositis, enhances the response of squamous cell carcinoma of the head and neck tumors to ionizing radiation, and enhances radioimmune therapy by Sishc, Brock James, Polsdofer, Elizabeth, Saha, Debabrata, Story, Michael

“…Abstract Locoregional recurrence (LRR) is the major cause of morbidity and mortality in patients with squamous cell carcinoma of the head and neck (HNSCC). For…”
Get full text

Tumor-treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines by Karanam, Narasimha Kumar, Srinivasan, Kalayarasan, Ding, Lianghao, Sishc, Brock, Saha, Debabrata, Story, Michael D

“…The use of tumor-treating fields (TTFields) has revolutionized the treatment of recurrent and newly diagnosed glioblastoma (GBM). TTFields are low-intensity,…”
Get full text

Abstract B51: Examining the differential cellular response of pancreatic cancer cell lines to 12C vs. photon irradiation by Saha, Janapriya, Story, Michael D., Davis, Anthony, Sishc, Brock J.

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is expected by 2020 to become the second most common cause of cancer-related deaths globally. The 5-year…”
Get full text

EXTH-24. EXPOSURE TO TUMOR TREATING FIELDS INHIBITS DNA REPAIR, INDUCES REPLICATION STRESS AND RENDERS TUMOR CELLS SENSITIVE TO AGENTS THAT IMPINGE UPON THESE PATHWAYS by Story, Michael, Karanam, Narasimha, Ding, Lianghao, Sishc, Brock, Saha, Debabrata

“…Abstract Tumor treating fields (TTFields) are low-intensity, intermediate frequency, alternating electric fields applied non-invasively across a tumor. Optune…”
Get full text

Abstract 3939: Exploiting tumor treating fields induced downregulation of BRCA1 pathway for novel combination therapies by Karanam, Narasimha Kumar, Ding, Liang-Hao, Sishc, Brock, Saha, Debabrata, Story, Michael D.

“…Abstract A new physical cancer treatment modality called Tumor Treating Fields (TTFields) has demonstrated effectiveness in the treatment of solid tumors in…”
Get full text

Abstract 2922: The radioprotector GC4419 enhances the response of squamous cell carcinoma of the head and neck tumors to ionizing radiation and enhances radioimmune therapy by Sishc, Brock J., Polsdofer, Elizabeth M., Zhang, Yuanyuan, Saha, Debabrata, Story, Michael D.

“…Abstract Locoregional recurrence (LRR) is the major cause of morbidity and mortality in patients with squamous cell carcinoma of the head and neck (HNSCC). For…”
Get full text

Abstract 3217: Newly identified role of tumor treating fields in DNA damage repair and replication stress pathways by Karanam, Narasimha Kumar, Ding, Lianghao, Sishc, Brock, Saha, Debabrata, Story, Michael D.

“…Abstract Tumor treating fields (TTFields) are low-intensity, intermediate frequency, alternating electric fields non-invasively applied to the region of the…”
Get full text