Search Results - "Sisco, Jay M"

Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I by Luzzio, Michael J, Besterman, Jeffrey M, Emerson, David L, Evans, Michael G, Lackey, Karen, Leitner, Peter L, McIntyre, Gordon, Morton, Bradley, Myers, Peter L, Peel, Michael, Sisco, Jay M, Sternbach, Daniel D, Tong, Wei-Qin, Truesdale, Ann, Uehling, David E, Vuong, Alan, Yates, Julie

“…The synthesis and antitumor activities of the novel water soluble camptothecin derivatives 7-[(4-methylpiperazino)methyl]-10,11-(methylenedioxy)-(20S)-campto…”
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Solubility behavior of lamivudine crystal forms in recrystallization solvents by Jozwiakowski, M J, Nguyen, N A, Sisco, J M, Spancake, C W

“…Lamivudine can be obtained as acicular crystals (form I, 0.2 hydrate) from water or methanol and as bipyramidal crystals (form II, nonsolvated) from many…”
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An unexpected hydrolysis pH-rate profile, at pH values less than 7, of the labile imide, ICRF-187 : (+)-1,2-bis-(3,5-dioxopiperazin-1-yl)propane by SISCO, J. M, STELLA, V. J

“…The hydrolysis of the cardioprotectant and anticancer agent, ICRF-187 (or ADR-529) and the structurally similar model compound, 4-methylpiperazine-2,6-dione…”
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Is ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane] unusually reactive for an imide ? by SISCO, J. M, STELLA, V. J

“…The hydrolysis of ICRF-187 and two model compounds, 4-methylpiperazine-2,6-dione (4-MP) and 3-methylglutarimide (3-MG), was investigated over the neutral to…”
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