Search Results - "Sirtori, Riccardo"
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Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis
Published in Nature communications (31-07-2020)“…Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by the degeneration of upper and lower motor neurons (MNs). We find a significant…”
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LINC complex alterations are a key feature of sporadic and familial ALS/FTD
Published in Acta neuropathologica communications (25-04-2024)“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects motor neurons, leading to progressive muscle weakness and loss of…”
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Indicators of Cardiovascular Risk in Metabolic Syndrome: Long Term Follow-up in Italian Patients
Published in Current vascular pharmacology (01-05-2017)“…Cardiovascular risk (CV) factors associated with the metabolic syndrome (MetS) may vary in different populations. In some, hypertension may be the major…”
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HSPA8 knock-down induces the accumulation of neurodegenerative disorder-associated proteins
Published in Neuroscience letters (25-09-2020)“…Highlights •HSPA8 knock-down induces HSPA1A overexpression.•HSPA8 and HSPA1A knock-down increases tau, SOD1 and α-synuclein protein levels.•HSPA8 knock-down or…”
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HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation
Published in Amyotrophic lateral sclerosis and frontotemporal degeneration (02-01-2020)“…Aim: The demonstration that chaperone-mediated autophagy (CMA) contributes to the degradation of TDP-43, the main constituent of cytoplasmic inclusions…”
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New players in the treatment of hypercholesterolaemia: focus on bempedoic acid and inclisiran
Published in European heart journal supplements (01-10-2021)“…Abstract Dyslipidaemias and in particular elevated plasma low-density lipoprotein cholesterol (LDL-C) levels are major risk factors for atherosclerotic…”
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High-density lipoprotein deficiency in genetically modified mice deeply affects skin morphology: A structural and ultrastructural study
Published in Experimental cell research (15-10-2015)“…Cutaneous lipids, endogenously synthetized and transported by lipoproteins, play a pivotal role in maintaining skin barrier. An impairment of extracutaneous…”
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