Search Results - "Sirovatka, Jeanne M"

Coenzyme B12 Chemical Precedent Studies:  Probing the Role of the Imidazole Base-on Motif Found in B12-Dependent Methylmalonyl-CoA Mutase by Sirovatka, Jeanne M, Finke, Richard G

“…Adenosylcobinamide (AdoCbi+) plus N-methylimidazole (N-MeIm), [AdoCbi·N-MeIm]+BF4 -, has been studied with the goal of providing a chemical precedent for the…”
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Molecular mechanics studies of coenzyme B12 complexes with constrained Co-N(axial-base) bond lengths: introduction of the universal force field (UFF) to coenzyme B12 chemistry and its use to probe the plausibility of an axial-base-induced, ground-state corrin butterfly conformational steric effect by Sirovatka, Jeanne M, Rappé, Anthony K, Finke, Richard G

“…The universal force field (UFF) is used to minimize a series of cobalamins to (i) test the applicability of UFF to model unstrained cobalamin structures in…”
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Coenzyme B12 Axial-Base Chemical Precedent Studies. Adenosylcobinamide Plus Sterically Hindered Axial-Base Co−C Bond Cleavage Product and Kinetic Studies:  Evidence for the Dominance of Axial-Base Transition-State Effects and for Co−N(Axial-Base) Distance-Dependent, Competing σ and π Effects by Sirovatka, Jeanne M, Finke, Richard G

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Coenzyme B12 Axial-Base Chemical Precedent Studies. † Adenosylcobinamide Plus Sterically Hindered Axial-Base Co−C Bond Cleavage Product and Kinetic Studies:  Evidence for the Dominance of Axial-Base Transition-State Effects and for Co−N(Axial-Base) Distance-Dependent, Competing σ and π Effects by Sirovatka, Jeanne M, Finke, Richard G

“…Adenosylcobinamide (AdoCbi+) plus the sterically hindered bases 1,2-dimethylimidazole, 2-methylpyridine, and 2,6-dimethylpyridine, as well as control…”
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Hydrogen abstraction from thiols by adenosyl radicals: chemical precedent for thiyl radical formation, the first catalytic step in ribonucleoside triphosphate reductase from Lactobacillus leichmannii by Sirovatka, Jeanne M, Finke, Richard G

“…Aqueous solutions of adenosylcobalamin (AdoCbl) were thermolyzed with excess β-mercaptoethanol under anaerobic conditions. The product studies reveal that ∼90%…”
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Adocobinamide, the Base-off Analog of Coenzyme B12 (Adocobalamin). 2. Probing the “Base-on” Effect in Coenzyme B12 via Cobalt−Carbon Bond Thermolysis Product and Kinetic Studies as a Function of Exogenous Pyridine Bases by Garr, Cheryl D, Sirovatka, Jeanne M, Finke, Richard G

“…The thermolysis of the Co−C bond in adocobinamide (AdoCbi+BF4 -) in anaerobic ethylene glycol has been studied as a function of a series of para-substituted…”
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Coenzyme B(12) Axial-Base Chemical Precedent Studies. Adenosylcobinamide Plus Sterically Hindered Axial-Base Co-C Bond Cleavage Product and Kinetic Studies: Evidence for the Dominance of Axial-Base Transition-State Effects and for Co-N(Axial-Base) Distance-Dependent, Competing sigma and pi Effects by Sirovatka, Jeanne M., Finke, Richard G.

“…Adenosylcobinamide (AdoCbi(+)) plus the sterically hindered bases 1,2-dimethylimidazole, 2-methylpyridine, and 2,6-dimethylpyridine, as well as control…”
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Coenzyme B 12 Chemical Precedent Studies:  Probing the Role of the Imidazole Base-on Motif Found in B 12 -Dependent Methylmalonyl-CoA Mutase by Sirovatka, Jeanne M., Finke, Richard G.

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Adenosylcobinamide, the Base-Free Analog of Coenzyme B12 (Adenosylcobalamin). 1. Probing the Role of the Axial 5,6-Dimethylbenzimidazole Base in Coenzyme B12 via Exogenous Axial Base Kassociation, ΔH, and ΔS Measurements plus a Critical Review of the Relevant Biochemical Literature by GARR, Cheryl D., FINKE, Richard G.

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Coenzyme B 12 Axial-Base Chemical Precedent Studies. Adenosylcobinamide Plus Sterically Hindered Axial-Base Co−C Bond Cleavage Product and Kinetic Studies:  Evidence for the Dominance of Axial-Base Transition-State Effects and for Co−N(Axial-Base) Distance-Dependent, Competing σ and π Effects by Sirovatka, Jeanne M., Finke, Richard G.

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Coenzyme B 12 Axial-Base Chemical Precedent Studies. Adenosylcobinamide Plus Sterically Hindered Axial-Base Co−C Bond Cleavage Product and Kinetic Studies:  Evidence for the Dominance of Axial-Base Transition-State Effects and for Co−N(Axial-Base) Distance-Dependent, Competing σ and π Effects by Sirovatka, Jeanne M., Finke, Richard G.

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Adocobinamide, the Base-off Analog of Coenzyme B 12 (Adocobalamin). 2. 1 Probing the “Base-on” Effect in Coenzyme B 12 via Cobalt−Carbon Bond Thermolysis Product and Kinetic Studies as a Function of Exogenous Pyridine Bases by Garr, Cheryl D., Sirovatka, Jeanne M., Finke, Richard G.

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Adenosylcobinamide, the Base-Free Analog of Coenzyme B 12 (Adenosylcobalamin). 1. 1 Probing the Role of the Axial 5,6-Dimethylbenzimidazole Base in Coenzyme B 12 via Exogenous Axial Base K association , Δ H , and Δ S Measurements plus a Critical Review of the Relevant Biochemical Literature by Garr, Cheryl D., Jeanne M. Sirovatka, and, Finke, Richard G.

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