Search Results - "Sirotnak, F."

Carrier-mediated membrane transport of folates in mammalian cells by Sirotnak, F.M, Tolner, B

“…Mediated internalization of folates is required for cellular macromolecular biosynthesis. Multiple carrier-mediated mechanisms have been identified that can…”
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Efficacy of Cytotoxic Agents against Human Tumor Xenografts Is Markedly Enhanced By Coadministration of ZD1839 (Iressa), an Inhibitor of EGFR Tyrosine Kinase by SIROTNAK, Francis M, ZAKOWSKI, Maureen F, MILLER, Vincent A, SCHER, Howard I, KRIS, Mark G

“…The blockade of epidermal growth factor receptor (EGFR) function with monoclonal antibodies has major antiproliferative effects against human tumors in vivo …”
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The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 Selectively Potentiates Radiation Response of Human Tumors in Nude Mice, with a Marked Improvement in Therapeutic Index by SHE, Yuhong, LEE, Fei, CHEN, Jing, HAIMOVITZ-FRIEDMAN, Adriana, MILLER, Vincent A, RUSCH, Valerie R, KRIS, Mark G, SIROTNAK, F. M

“…Purpose: The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) markedly potentiates the efficacy of many cytotoxic agents against…”
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Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency by Said, H M, Chatterjee, N, Haq, R U, Subramanian, V S, Ortiz, A, Matherly, L H, Sirotnak, F M, Halsted, C, Rubin, S A

“…Folate is an essential micronutrient that, in mammals, must be obtained from exogenous sources via intestinal absorption. Previous studies have characterized…”
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A Population Pharmacokinetic and Pharmacodynamic Evaluation of Pralatrexate in Patients With Relapsed or Refractory Non-Hodgkin's or Hodgkin's Lymphoma by Mould, DR, Sweeney, K, Duffull, SB, Neylon, E, Hamlin, P, Horwitz, S, Sirotnak, F, Fleisher, M, Saunders, ME, O'Connor, OA

“…In a pralatrexate phase I study, patients displayed a high incidence of mucositis of grades 3 and 4. Preliminary evaluations of the pharmacokinetics of the…”
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A phase I trial of intermittent high-dose gefitinib and fixed-dose docetaxel in patients with advanced solid tumors by FURY, Matthew G, SOLIT, David B, PIZZO, Barbara A, HENRY, Roxanne, PFISTER, David G, RIZVI, Naiyer A, SU, Yungpo Bernard, ROSEN, Neal, SIROTNAK, F. M, SMITH, Robert P, AZZOLI, Christopher G, GOMEZ, Jorge E, MILLER, Vincent A, KRIS, Mark G

“…Based on our mouse xenograft model demonstrating that intermittent high-dose gefitinib sensitizes tumors to subsequent treatment with taxanes, we initiated…”
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A Phase 1 Study of Pralatrexate in Combination with Paclitaxel or Docetaxel in Patients with Advanced Solid Tumors by AZZOLI, Christopher G, KRUG, Lee M, PIZZO, Barbara, FARMER, Amy, VENKATRAMAN, Ennapadam, STEFFEN, Robert, SIROTNAK, F. M, GOMEZ, Jorge, MILLER, Vincent A, KRIS, Mark G, GINSBERG, Michelle S, HENRY, Roxanne, JONES, Jessica, TYSON, Leslie, DUNNE, Megan

“…Purpose: Pralatrexate is a rationally designed antifolate with greater preclinical antitumor activity than methotrexate. Pralatrexate was synergistic with…”
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Activity of a Novel Anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against Human Lymphoma is Superior to Methotrexate and Correlates with Tumor RFC-1 Gene Expression by Wang, Eunice S., O'Connor, Owen, She, Yuhong, Zelenetz, Andrew D., Sirotnak, F.M., Moore, Malcolm A.S.

“…PDX (10-propargyl-10-deazaaminopterin) is a novel anti-folate with improved membrane transport and polyglutamylation in tumor cells. In prior studies, PDX…”
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10-Propargyl-10-deazaaminopterin: An antifolate with activity in Patients with previously treated non-small cell lung cancer by KRUG, Lee M, AZZOLI, Christopher G, BAEZ, Valerie, NG, Kenneth K, SIROTNAK, F. M, KRIS, Mark G, MILLER, Vincent A, KHOKHAR, Nushmia Z, TONG, William, GINSBERG, Michelle S, VENKATRAMAN, Ennapadam, TYSON, Leslie, PIZZO, Barbara

“…10-propargyl-10-deazaaminopterin (PDX) has superior antitumor efficacy in mouse xenograft models, likely attributable to increased uptake by the RFC-1 folate…”
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Pralatrexate with vitamin supplementation in patients with previously treated, advanced non-small cell lung cancer: safety and efficacy in a phase 1 trial by Azzoli, Christopher G, Patel, Jyoti D, Krug, Lee M, Miller, Vincent, James, Leonard, Kris, Mark G, Ginsberg, Michelle, Subzwari, Sara, Tyson, Leslie, Dunne, Megan, May, Jennifer, Huntington, Martha, Saunders, Michael, Sirotnak, F M

“…Pralatrexate is an antifolate designed for preferential tumor cell uptake and accumulation and received accelerated Food and Drug Administration approval in…”
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Phase II trial of pralatrexate (10-propargyl-10-deazaaminopterin, PDX) in patients with unresectable malignant pleural mesothelioma by Krug, Lee M, Heelan, Robert T, Kris, Mark G, Venkatraman, Ennapadam, Sirotnak, F M

“…Several previous clinical trials have shown that malignant pleural mesothelioma is responsive to antifolates. The dihydrofolate reductase inhibitor,…”
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Phase I and Pharmacokinetic Study of 10-Propargyl-10-deazaaminopterin, a New Antifolate by KRUG, Lee M, NG, Kenneth K, KRIS, Mark G, MILLER, Vincent A, TONG, William, HEELAN, Robert T, LEON, Larry, LEUNG, Denis, KELLY, Jean, SIROTNAK, F. M

“…The 10-deazaaminopterins are a new class of rationally designed antifolates demonstrating greater antitumor effects than methotrexate in murine tumor models…”
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Microarray analysis of prostate cancer progression to reduced androgen dependence: Studies in unique models contrasts early and late molecular events by Sirotnak, F.M., She, Yuhong, Khokhar, Nushmia Z., Hayes, Paula, Gerald, William, Scher, Howard I.

“…Three unique variants of the CWR22 human prostate cancer xenograft model (CWR22LD1, LD2, and LD3) with a decrease in dependence on androgens were selected…”
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RFC-1 Gene Expression Regulates Folate Absorption in Mouse Small Intestine by Chiao, J H, Roy, K, Tolner, B, Yang, C H, Sirotnak, F M

“…Mediated folate compound transport inward in isolated luminal epithelial cells from mouse small intestine was delineated as pH-dependent and non-pH-dependent…”
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Structural analysis of the human RFC-1 gene encoding a folate transporter reveals multiple promoters and alternatively spliced transcripts with 5′ end heterogeneity by Tolner, Berend, Roy, Krishnendu, Sirotnak, F.M

“…The organization and structure of the human RFC-1 gene encoding a folate transporter were determined. The RFC-1 gene spans 22.5 kb and was found to be…”
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A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice by SIROTNAK, F. M, DEGRAW, J. I, COLWELL, W. T, PIPER, J. R

“…These studies sought to evaluate the biochemical and cellular pharmacokinetic properties, cytotoxicity and antitumor efficacy of a new analogue of…”
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Co-administration of Probenecid, an Inhibitor of a cMOAT/MRP- like Plasma Membrane ATPase, Greatly Enhanced the Efficacy of a New 10-Deazaaminopterin against Human Solid Tumors in Vivo by SIROTNAK, F. M, WENDEL, H. Guido, BORNMANN, William G. B, TONG, William P, MILLER, Vincent A, SCHER, Howard I, KRIS, Mark G

“…Earlier studies from this laboratory have shown that the uricosuric agent probenecid (PBCD) will inhibit the extrusion of folate analogues from tumor cells…”
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A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter within the plasma membrane of tumor cells by Roy, K, Tolner, B, Chiao, J H, Sirotnak, F M

“…The apparent Km, but not Vmax, for influx of methotrexate (MTX) mediated through the plasma membrane of S180 cells by the one-carbon, reduced folate…”
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Augmentation of Apoptosis and Tumor Regression by Flavopiridol in the Presence of CPT-11 in Hct116 Colon Cancer Monolayers and Xenografts by MOTWANI, Monica, JUNG, Christoph, SIROTNAK, Francis M, YUHONG SHE, SHAH, Manish A, GONEN, Mithat, SCHWARTZ, Gary K

“…CPT-11, a DNA topoisomerase I inhibitor, has demonstrated clinical activity in colorectal cancer. Flavopiridol, a cyclin-dependent kinase inhibitor, is rapidly…”
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Regulation of transcription of the murine gamma-glutamyl hydrolase gene. Delineation of core promoter A and the role of LYF-1, E2F and ETS-1 in determining tumor-specific expression by Masumoto, Naoko, Chen, Jing, Sirotnak, F M

“…Our earlier studies (Gene 268 (2001) 183) showed that transcription of the mouse gamma-glutamyl hydrolase (gamma GH) gene is under the control of two separate…”
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