Search Results - "Siroky, J."

Renal disease in tuberous sclerosis complex: pathogenesis and therapy by Lam, Hilaire C., Siroky, Brian J., Henske, Elizabeth P.

“…Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by hamartomatous tumours of the brain, heart, skin, lung and kidney. Patients…”
Get full text

The TRPP2-dependent channel of renal primary cilia also requires TRPM3 by Kleene, Steven J, Siroky, Brian J, Landero-Figueroa, Julio A, Dixon, Bradley P, Pachciarz, Nolan W, Lu, Lu, Kleene, Nancy K

“…Primary cilia of renal epithelial cells express several members of the transient receptor potential (TRP) class of cation-conducting channel, including TRPC1,…”
Get full text

Improvement in Renal Cystic Disease of Tuberous Sclerosis Complex After Treatment with Mammalian Target of Rapamycin Inhibitor by Siroky, Brian J., PhD, Towbin, Alexander J., MD, Trout, Andrew T., MD, Schäfer, Hannah, MD, Thamann, Anna R., MPhil, Agricola, Karen D., MSN, APRN, FNP-BC, Tudor, Cynthia, MSN, CNP, Capal, Jamie, MD, Dixon, Bradley P., MD, Krueger, Darcy A., MD, PhD, Franz, David N., MD

“…Renal cysts occur in approximately 50% of patients with tuberous sclerosis complex, but their clinical significance and response to treatment are unknown…”
Get full text

Characterization of Renal Toxicity in Mice Administered the Marine Biotoxin Domoic Acid by FUNK, Jason A, JANECH, Michael G, DILLON, Joshua C, BISSLER, John J, SIROKY, Brian J, DARWIN BELL, P

“…Domoic acid (DA), an excitatory amino acid produced by diatoms belonging to the genus Pseudo-nitzschia, is a glutamate analog responsible for the neurologic…”
Get full text

Chromosome landmarks as tools to study the genome of Arabidopsis thaliana by Siroky, J

“…The model plant Arabidopsis thaliana has long been used for genetic, cellular and molecular studies. Whereas this plant was used as a model of genetics in the…”
Get more information

Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress by Siroky, Brian J, Yin, Hong, Babcock, Justin T, Lu, Lu, Hellmann, Anna R, Dixon, Bradley P, Quilliam, Lawrence A, Bissler, John J

“…Tuberous sclerosis complex (TSC), an inherited tumor predisposition syndrome associated with mutations in TSC1 or TSC2, affects ∼1 in 6,000 individuals. Eighty…”
Get more information

Cytogenetics for the study of telomere function in plants by Siroky, J

“…The ends of linear chromosomes of the vast majority of eukaryotic species possess specialized nucleo-protein structures called telomeres. Regardless of many…”
Get more information

Cell cycle control and DNA damage response of conditionally immortalized urothelial cells by Dixon, Bradley P, Henry, Jeff, Siroky, Brian J, Chu, Albert, Groen, Pamela A, Bissler, John J

“…Children with complex urogenital anomalies often require bladder reconstruction. Gastrointestinal tissues used in bladder augmentations exhibit a greatly…”
Get full text

Loss of primary cilia results in deregulated and unabated apical calcium entry in ARPKD collecting duct cells by Siroky, Brian J, Ferguson, William B, Fuson, Amanda L, Xie, Yi, Fintha, Attila, Komlosi, Peter, Yoder, Bradley K, Schwiebert, Erik M, Guay-Woodford, Lisa M, Bell, P Darwin

“…Recent genetic analysis has identified a pivotal role of primary cilia in the pathogenesis of polycystic kidney disease (PKD). However, little is known…”
Get more information

Chromatin fragmentation associated with apoptotic changes in tobacco cells exposed to cold stress by Koukalová, Blazˇena, Kovarˇík, Alesˇ, Fajkus, Jirˇí, Sˇiroký, Jirˇí

“…Programmed cell death (PCD) may be triggered by a variety of environmental stimuli. In this report we show that low temperature treatment of tobacco BY-2 cells…”
Get full text

Glomerulocystic kidney disease by Bissler, John J., Siroky, Brian J., Yin, Hong

“…Glomerulocystic disease is a rare renal cystic disease with a long descriptive history. Findings from recent studies have significantly advanced the…”
Get full text

Heterogeneity of rDNA distribution and genome size in Silene spp by Siroký, J, Lysák, M A, Dolezel, J, Kejnovský, E, Vyskot, B

“…Genus Silene L. (Caryophyllaceae) contains about 700 species divided into 44 sections. According to recent taxonomic classification this genus also includes…”
Get full text

Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3 by Siroky, Brian J, Kleene, Nancy K, Kleene, Steven J, Varnell, Jr, Charles D, Comer, Raven G, Liu, Jialiu, Lu, Lu, Pachciarz, Nolan W, Bissler, John J, Dixon, Bradley P

“…Primary cilia sense environmental conditions, including osmolality, but whether cilia participate in the osmotic response in renal epithelial cells is not…”
Get more information

Localization of Male-Specifically Expressed MROS Genes of Silene latifolia by PCR on Flow-Sorted Sex Chromosomes and Autosomes by Kejnovsky, Eduard, Vrana, Jan, Matsunaga, Sachihiro, Soucek, Premysl, Siroky, Jiri, Dolezel, Jaroslav, Vyskot, Boris

“…The dioecious white campion Silene latifolia (syn. Melandrium album) has heteromorphic sex chromosomes, XX in females and XY in males, that are larger than the…”
Get full text

Clinical and Molecular Insights into Tuberous Sclerosis Complex Renal Disease by Siroky, Brian J., Yin, Hong, Bissler, John J.

“…Patients with tuberous sclerosis complex are at great risk of developing renal lesions as part of their disease. These lesions include renal cysts and tumors…”
Get full text

Evidence for pericyte origin of TSC-associated renal angiomyolipomas and implications for angiotensin receptor inhibition therapy by Siroky, Brian J, Yin, Hong, Dixon, Bradley P, Reichert, Ryan J, Hellmann, Anna R, Ramkumar, Thiruvamoor, Tsuchihashi, Zenta, Bunni, Marlene, Dillon, Joshua, Bell, P Darwin, Sampson, Julian R, Bissler, John J

“…Nearly all patients with tuberous sclerosis complex (TSC) develop renal angiomyolipomas, although the tumor cell of origin is unknown. We observed decreased…”
Get more information

Tuberous sclerosis complex exhibits a new renal cystogenic mechanism by Bissler, John J., Zadjali, Fahad, Bridges, Dave, Astrinidis, Aristotelis, Barone, Sharon, Yao, Ying, Redd, JeAnna R., Siroky, Brian J., Wang, Yanqing, Finley, Joel T., Rusiniak, Michael E., Baumann, Heinz, Zahedi, Kamyar, Gross, Kenneth W., Soleimani, Manoocher

“…Tuberous sclerosis complex (TSC) is a tumor predisposition syndrome with significant renal cystic and solid tumor disease. While the most common renal tumor in…”
Get full text

Hyperglycemia in the absence of cilia accelerates cystogenesis and induces renal damage by Sas, Kelli M, Yin, Hong, Fitzgibbon, Wayne R, Baicu, Catalin F, Zile, Michael R, Steele, Stacy L, Amria, May, Saigusa, Takamitsu, Funk, Jason, Bunni, Marlene A, Siegal, Gene P, Siroky, Brian J, Bissler, John J, Bell, P Darwin

“…In polycystic kidney disease (PKD), the rate of cyst formation and disease progression is highly variable. The lack of predictability in disease progression…”
Get more information

Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells by Li, Chenggang, Liu, Xiaolei, Liu, Yang, Zhang, Erik, Medepalli, Kantha, Masuda, Kouhei, Li, Na, Wikenheiser-Brokamp, Kathryn A, Osterburg, Andrew, Borchers, Michael T, Kopras, Elizabeth J, Plas, David R, Sun, Julia, Franz, David N, Capal, Jamie K, Mays, Maxwell, Sun, Yang, Kwiatkowski, David J, Alayev, Anya, Holz, Marina K, Krueger, Darcy A, Siroky, Brian J, Yu, Jane J

“…Tuberous sclerosis complex (TSC) is a tumor-suppressor syndrome affecting multiple organs, including the brain, skin, kidneys, heart, and lungs. TSC is…”
Get full text

Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors by Saigusa, Takamitsu, Reichert, Ryan, Guare, Jennifer, Siroky, Brian J, Gooz, Monika, Steele, Stacy, Fenton, Robert A, Bell, P Darwin, Kolb, Robert J

“…Polycystic kidney disease (PKD) is a ciliopathy characterized by renal cysts and hypertension. These changes are presumably due to altered fluid and…”
Get more information