Search Results - "Sirois, Suzanne"

Progress in computational approach to drug development against SARS by Chou, Kuo-Chen, Wei, Dong-Qing, Du, Qi-Shi, Sirois, Suzanne, Zhong, Wei-Zhu

“…Since the outbreak of SARS (severe acute respiratory syndrome) in November 2002 in Southern China's Guangdong Province, considerable progress has been made in…”
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Glycosylation of HIV-1 gp120 V3 loop: towards the rational design of a synthetic carbohydrate vaccine by Sirois, Suzanne, Touaibia, Mohamed, Chou, Kuo-Chen, Roy, René

“…A wide variety of proteins can bind high-mannose oligosaccharides and are broadly neutralizing against HIV-1. However, success in eliciting broadly…”
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A first QSAR model for galectin-3 glycomimetic inhibitors based on 3D docked structures by Sirois, Suzanne, Giguère, Denis, Roy, René

“…This study presents the first QSAR model for Galectin-3 glycomimetic inhibitors based on docked structures to the carbohydrate recognition domain (CRD)…”
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HIV-1 gp120 V3 loop for structure-based drug design by Sirois, Suzanne, Sing, Tobias, Chou, Kuo-Chen

“…HIV-1 cell entry is mediated by sequential interactions of the envelope protein gp120 with the receptor CD4 and a coreceptor, usually CCR5 or CXCR4, depending…”
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Mannosylated G(0) Dendrimers with Nanomolar Affinities to Escherichia coli FimH by Touaibia, Mohamed, Wellens, Adinda, Shiao, Tze Chieh, Wang, Qingan, Sirois, Suzanne, Bouckaert, Julie, Roy, René

“…Pentaerythritol and bis‐pentaerythritol scaffolds were used for the preparation of first generation glycodendrimers bearing aryl α‐D‐mannopyranoside residues…”
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Virtual Screening for SARS-CoV Protease Based on KZ7088 Pharmacophore Points by Sirois, Suzanne, Wei, Dong-Qing, Du, Qishi, Chou, Kuo-Chen

“…Pharmacophore modeling can provide valuable insight into ligand−receptor interactions. It can also be used in 3D (dimensional) database searching for…”
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Molecular modeling and chemical modification for finding peptide inhibitor against severe acute respiratory syndrome coronavirus main proteinase by Du, Qishi, Wang, Shuqing, Wei, Dongqing, Sirois, Suzanne, Chou, Kuo-Chen

“…Severe acute respiratory syndrome (SARS) is a respiratory disease caused by a newly found virus, called SARS coronavirus. In this study, the cleavage mechanism…”
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Aryl O- and S-galactosides and lactosides as specific inhibitors of human galectins-1 and -3: Role of electrostatic potential at O-3 by Giguère, Denis, Sato, Sachiko, St-Pierre, Christian, Sirois, Suzanne, Roy, René

“…Aryl O- and S-galactosides, and lactosides were prepared and used for the specific inhibition of galectins-1 and -3. In inhibition of hemagglutination assay…”
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Polyprotein cleavage mechanism of SARS CoV M pro and chemical modification of the octapeptide by Du, Qi-Shi, Wang, Shu-Qing, Zhu, Yu, Wei, Dong-Qing, Guo, Hong, Sirois, Suzanne, Chou, Kuo-Chen

“…The cleavage mechanism of severe acute respiratory syndrome (SARS) coronavirus main proteinase (M pro or 3CL pro) for the octapeptide AVLQSGFR is studied using…”
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Bayesian versus Frequentist statistical modeling: A debate for hit selection from HTS campaigns by Cloutier, L. Martin, Sirois, Suzanne

“…The existing literature suggests the Bayesian–Frequentist debate could soon be involved in the prioritization of hits from HTS campaigns. The…”
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Needed: system dynamics for the drug discovery process by Sirois, Suzanne, Cloutier, L. Martin

“…A system dynamics structure to characterize the link between technology and critical management decisions in the drug discovery process (DDP) is needed. The…”
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Assessment of chemical libraries for their druggability by Sirois, Suzanne, Hatzakis, George, Wei, Dongqing, Du, Qishi, Chou, Kuo-Chen

“…High throughput virtual screening is acknowledged as the initial means for identifying hit compounds that will be eventually transformed to leads or drug…”
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Cover Picture: Mannosylated G(0) Dendrimers with Nanomolar Affinities to Escherichia coli FimH (ChemMedChem 8/2007) by Touaibia, Mohamed, Wellens, Adinda, Shiao, Tze Chieh, Wang, Qingan, Sirois, Suzanne, Bouckaert, Julie, Roy, René

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Polyprotein cleavage mechanism of SARS CoV Mpro and chemical modification of the octapeptide by DU, Qi-Shi, WANG, Shu-Qing, YU ZHU, WEI, Dong-Qing, HONG GUO, SIROIS, Suzanne, CHOU, Kuo-Chen

“…The cleavage mechanism of severe acute respiratory syndrome (SARS) coronavirus main proteinase (M(pro) or 3CL(pro)) for the octapeptide AVLQSGFR is studied…”
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Applications de la theorie de la fonctionnelle de la densite aux systemes (bio)organiques et inorganiques: Vers un protocole pour la modelisation moleculaire quantique by Sirois, Suzanne

“…Les methodes ab initio Hartree-Fock (HF) et post-HF de chimie quantique ont ete surtout confinees a de petits systemes. De toutes les methodes ab initio, celle…”
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