Search Results - "Sirois, Cherilyn M"

IFI16 is an innate immune sensor for intracellular DNA by Bowie, Andrew G, Unterholzner, Leonie, Keating, Sinead E, Baran, Marcin, Horan, Kristy A, Jensen, Søren B, Sharma, Shruti, Sirois, Cherilyn M, Jin, Tengchuan, Latz, Eicke, Xiao, T Sam, Fitzgerald, Katherine A, Paludan, Søren R

“…Foreign nucleic acids trigger innate immune sensors. Bowie and colleagues identify the PYHIN protein IFI16 as an innate duplex DNA sensor that triggers IFN-β…”
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Inflammatory status and severity of disease in dengue patients are associated with lipoprotein alterations by Marin-Palma, Damariz, Sirois, Cherilyn M, Urcuqui-Inchima, Silvio, Hernandez, Juan C

“…The triggering of severe dengue has been associated with an exacerbated inflammatory process characterized by the production of pro-inflammatory cytokines such…”
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Ligand-induced conformational changes allosterically activate Toll-like receptor 9 by Latz, Eicke, Golenbock, Douglas T, Verma, Anjali, Visintin, Alberto, Gong, Mei, Sirois, Cherilyn M, Klein, Dionne C G, Monks, Brian G, McKnight, C James, Lamphier, Marc S, Duprex, W Paul, Espevik, Terje

“…Microbial and synthetic DNA rich in CpG dinucleotides stimulates Toll-like receptor 9 (TLR9), whereas DNA lacking CpG either is inert or can inhibit TLR9…”
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TLR9 and the Recognition of Self and Non-Self Nucleic Acids by LAMPHIER, MARC S., SIROIS, CHERILYN M., VERMA, ANJALI, GOLENBOCK, DOUGLAS T., LATZ, EICKE

“…:  Toll‐like receptors (TLRs) are involved in the innate recognition of foreign material and their activation leads to both innate and adaptive immune…”
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Natural Loss-of-function Mutation of Myeloid Differentiation Protein 88 Disrupts Its Ability to Form Myddosomes by Nagpal, Kamalpreet, Plantinga, Theo S., Sirois, Cherilyn M., Monks, Brian G., Latz, Eicke, Netea, Mihai G., Golenbock, Douglas T.

“…Myeloid differentiation protein 88 (MyD88) is a key signaling adapter in Toll-like receptor (TLR) signaling. MyD88 is also one of the most polymorphic adapter…”
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals by Sirois, Cherilyn M, Latz, Eicke, Fitzgerald, Katherine A, Rayner, Katey J, Kono, Hajime, Espevik, Terje, Hornung, Veit, Abela, George S, Schnurr, Max, Lien, Egil, Wright, Samuel D, Vladimer, Gregory, Nuñez, Gabriel, Rock, Kenneth L, Duewell, Peter, Bauernfeind, Franz G, Franchi, Luigi, Moore, Kathryn J

“…The inflammatory nature of atherosclerosis is well established but the agent(s) that incite inflammation in the artery wall remain largely unknown. Germ-free…”
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Particulate matter air pollution from the city of Quito, Ecuador, activates inflammatory signaling pathways in vitro by Cevallos, Victoria M, Díaz, Valeria, Sirois, Cherilyn M

“…Automobile traffic, industrial processes and natural phenomena cause notable air pollution, including gaseous and particulate contaminants, in urban centers…”
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RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA by Sirois, Cherilyn M, Jin, Tengchuan, Miller, Allison L, Bertheloot, Damien, Nakamura, Hirotaka, Horvath, Gabor L, Mian, Abubakar, Jiang, Jiansheng, Schrum, Jacob, Bossaller, Lukas, Pelka, Karin, Garbi, Natalio, Brewah, Yambasu, Tian, Jane, Chang, ChewShun, Chowdhury, Partha S, Sims, Gary P, Kolbeck, Roland, Coyle, Anthony J, Humbles, Alison A, Xiao, T Sam, Latz, Eicke

“…Recognition of DNA and RNA molecules derived from pathogens or self-antigen is one way the mammalian immune system senses infection and tissue damage…”
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Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling by Gray, Pearl, Michelsen, Kathrin S, Sirois, Cherilyn M, Lowe, Emily, Shimada, Kenichi, Crother, Timothy R, Chen, Shuang, Brikos, Constantinos, Bulut, Yonca, Latz, Eicke, Underhill, David, Arditi, Moshe

“…Myeloid differentiation factor 2 (MD-2) is a secreted gp that assembles with TLR4 to form a functional signaling receptor for bacterial LPS. In this study, we…”
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'Toll2008' outgrows its name by Sirois, Cherilyn M, Hornung, Veit, Latz, Eicke

“…On 24–27 September 2008, members of the scientific community gathered to discuss advances in innate immunity at the 'Toll meeting' in Cascais, Portugal. Before…”
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals by Duewell, Peter, Kono, Hajime, Rayner, Katey J, Sirois, Cherilyn M, Vladimer, Gregory, Bauernfeind, Franz G, Abela, George S, Franchi, Luigi, Nuñez, Gabriel, Schnurr, Max, Espevik, Terje, Lien, Egil, Fitzgerald, Katherine A, Rock, Kenneth L, Moore, Kathryn J, Wright, Samuel D, Hornung, Veit, Latz, Eicke

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9 by Bertheloot, Damien, Sirois, Cherilyn M., Miller, Allison L., Jin, Tengchuan, Garbi, Natalio, Sam Xiao, T., Latz, Eicke

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9: RAGE is a cell surface nucleic acid sensor by Bertheloot, Damien, Sirois, Cherilyn M., Miller, Allison L., Jin, Tengchuan, Garbi, Natalio, Sam Xiao, T., Latz, Eicke

“…RAGE is a multi-ligand cell surface receptor of the Immunoglobulin super-family. It is composed of three extracellular immunoglobulin-like domains (V, C1 and…”
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RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA by Sirois, Cherilyn M., Jin, Tengchuan, Miller, Allison L., Bertheloot, Damien, Nakamura, Hirotaka, Horvath, Gabor L., Mian, Abubakar, Jiang, Jiansheng, Schrum, Jacob, Bossaller, Lukas, Pelka, Karin, Garbi, Natalio, Brewah, Yambasu, Tian, Jane, Chang, ChewShun, Chowdhury, Partha S., Sims, Gary P., Kolbeck, Roland, Coyle, Anthony J., Humbles, Alison A., Xiao, T. Sam, Latz, Eicke

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RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA by Sirois, Cherilyn M, Jin, Tengchuan, Miller, Allison L, Bertheloot, Damien, Nakamura, Hirotaka, Horvath, Gabor L, Mian, Abubakar, Jiang, Jiansheng, Schrum, Jacob, Bossaller, Lukas, Pelka, Karin, Garbi, Natalio, Brewah, Yambasu, Tian, Jane, Chang, Chew-Shun, Chowdhury, Partha, Sims, Gary, Kolbeck, Roland, Coyle, Anthony, Humbles, Alison, Xiao, T. Sam, Latz, Eicke

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Identification of a novel human MD-2 splice variant that negatively regulates LPS-induced Toll-like receptor 4 signaling by Gray, Pearl, Michelsen, Kathrin S., Sirois, Cherilyn M., Lowe, Emily, Shimada, Kenichi, Crother, Timothy R., Chen, Shuang, Brikos, Constantinos, Bulut, Yonca, Latz, Eicke, Underhill, David, Arditi, Moshe

“…Myeloid differentiation factor 2 (MD-2) is a secreted glycoprotein that assembles with Toll-like receptor 4 (TLR4) to form a functional signaling receptor for…”
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Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals by Duewell, Peter, Kono, Hajime, Rayner, Katey J., Sirois, Cherilyn M., Vladimer, Gregory, Bauernfeind, Franz G., Abela, George S., Franchi, Luigi, Nuñez, Gabriel, Schnurr, Max, Espevik, Terje, Lien, Egil, Fitzgerald, Katherine A., Rock, Kenneth L., Moore, Kathryn J., Wright, Samuel D., Hornung, Veit, Latz, Eicke

“…Nature 464, 1357–1361 (2010) In this Letter, the address for author Veit Hornung was listed incorrectly. The correct address is: The Institute of Clinical…”
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NLRP3 inflamasomes are required for atherogenesis and activated by cholesterol crystals that form early in disease by Duewell, Peter, Kono, Hajime, Rayner, Katey J., Sirois, Cherilyn M., Vladimer, Gregory, Bauernfeind, Franz G., Abela, George S., Franchi, Luigi, Nuñez, Gabriel, Schnurr, Max, Espevik, Terje, Lien, Egil, Fitzgerald, Katherine A, Rock, Kenneth L., Moore, Kathryn J., Wright, Samuel D, Hornung, Veit, Latz, Eicke

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Corrigendum: Ligand-induced conformational changes allosterically activate Toll-like receptor 9 by Latz, Eicke, Verma, Anjali, Visintin, Alberto, Gong, Mei, Sirois, Cherilyn M, Klein, Dionne C G, Monks, Brian G, McKnight, C James, Lamphier, Marc S, Duprex, W Paul, Espevik, Terje, Golenbock, Douglas T

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Erratum: Corrigendum: Ligand-induced conformational changes allosterically activate Toll-like receptor 9 by Latz, Eicke, Verma, Anjali, Visintin, Alberto, Gong, Mei, Sirois, Cherilyn M, Klein, Dionne C G, Monks, Brian G, McKnight, C James, Lamphier, Marc S, Duprex, W Paul, Espevik, Terje, Golenbock, Douglas T

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