Search Results - "Siriwardena, Sachini U"

Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases by Siriwardena, Sachini U, Chen, Kang, Bhagwat, Ashok S

“…The AID/APOBEC family enzymes convert cytosines in single-stranded DNA to uracils, causing base substitutions and strand breaks. They are induced by cytokines…”
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Phosphorylation-Inducing Chimeric Small Molecules by Siriwardena, Sachini U, Munkanatta Godage, Dhanushka N. P, Shoba, Veronika M, Lai, Sophia, Shi, Mengchao, Wu, Peng, Chaudhary, Santosh K, Schreiber, Stuart L, Choudhary, Amit

“…Small molecules have been classically developed to inhibit enzyme activity; however, new classes of small molecules that endow new functions to enzymes via…”
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A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9 by Maji, Basudeb, Gangopadhyay, Soumyashree A., Lee, Miseon, Shi, Mengchao, Wu, Peng, Heler, Robert, Mok, Beverly, Lim, Donghyun, Siriwardena, Sachini U., Paul, Bishwajit, Dančík, Vlado, Vetere, Amedeo, Mesleh, Michael F., Marraffini, Luciano A., Liu, David R., Clemons, Paul A., Wagner, Bridget K., Choudhary, Amit

“…The precise control of CRISPR-Cas9 activity is required for a number of genome engineering technologies. Here, we report a generalizable platform that provided…”
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A Tumor-Promoting Phorbol Ester Causes a Large Increase in APOBEC3A Expression and a Moderate Increase in APOBEC3B Expression in a Normal Human Keratinocyte Cell Line without Increasing Genomic Uracils by Siriwardena, Sachini U., Perera, Madusha L. W., Senevirathne, Vimukthi, Stewart, Jessica, Bhagwat, Ashok S.

“…Phorbol 12-myristate 13-acetate (PMA) promotes skin cancer in rodents. The mutations found in murine tumors are similar to those found in human skin cancers,…”
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Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine by Siriwardena, Sachini U., Guruge, Thisari A., Bhagwat, Ashok S.

“…Human APOBEC3B deaminates cytosines in DNA and belongs to the AID/APOBEC family of enzymes. These proteins are involved in innate and adaptive immunity and may…”
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Development and Applications of Chimera Platforms for Tyrosine Phosphorylation by Pergu, Rajaiah, Shoba, Veronika M, Chaudhary, Santosh K, Munkanatta Godage, Dhanushka N P, Deb, Arghya, Singha, Santanu, Dhawa, Uttam, Singh, Prashant, Anokhina, Viktoriya, Singh, Sameek, Siriwardena, Sachini U, Choudhary, Amit

“…Chimeric small molecules that induce post-translational modification (PTM) on a target protein by bringing it into proximity to a PTM-inducing enzyme are…”
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A Jumbo Phage Forms a Nucleus-like Compartment to Evade Bacterial Defense Systems by Modell, Ashley E, Siriwardena, Sachini U, Choudhary, Amit

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Synthetic Reprogramming of Kinases Expands Cellular Activities of Proteins by Shoba, Veronika M., Munkanatta Godage, Dhanushka N. P., Chaudhary, Santosh K., Deb, Arghya, Siriwardena, Sachini U., Choudhary, Amit

“…Phosphorylation‐inducing chimeric small molecules (PHICS) can enable a kinase to act at a new cellular location or phosphorylate non‐native substrates…”
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Chemical and optical control of CRISPR-associated nucleases by Modell, Ashley E., Siriwardena, Sachini U., Shoba, Veronika M., Li, Xing, Choudhary, Amit

“…The clustered regularly interspaced short palindromic repeats (CRISPR)–Cas system of bacteria has furnished programmable nucleases (e.g., Cas9) that are…”
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Synthetic Reprogramming of Kinases Expands Cellular Activities of Proteins by Shoba, Veronika M., Munkanatta Godage, Dhanushka N. P., Chaudhary, Santosh K., Deb, Arghya, Siriwardena, Sachini U., Choudhary, Amit

“…Phosphorylation‐inducing chimeric small molecules (PHICS) can enable a kinase to act at a new cellular location or phosphorylate non‐native substrates…”
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APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response by Conner, Kayla L, Shaik, Asra N, Marshall, Katie A, Floyd, Ashley M, Ekinci, Elmira, Lindquist, Jacob, Sawant, Akshada, Lei, Wen, Adolph, Madison B, Chelico, Linda, Siriwardena, Sachini U, Bhagwat, Ashok, Kim, Seongho, Cote, Michele L, Patrick, Steve M

“…Identifying the mechanisms mediating cisplatin response is essential for improving patient response. Previous research has identified base excision repair…”
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