Electrosprayed Nanoparticles Containing Mangiferin-Rich Extract from Mango Leaves for Cosmeceutical Application

Electrosprayed Nanoparticles Containing Mangiferin-Rich Extract from Mango Leaves for Cosmeceutical Application

Mango (Mangifera indica L.) is one of the most economically important fruits in Thailand. Mango has been used as a traditional medicine because it possesses many biological activities, such as antioxidant properties, anti-inflammatory properties, microorganism-growth inhibition, etc. Among its natur...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Vol. 13; no. 22; p. 2931
Main Authors: Sirirungsee, Vissuta, Samutrtai, Pawitrabhorn, Sangthong, Padchanee, Papan, Phakorn, Leelapornpisid, Pimporn, Saenjum, Chalermpong, Sirithunyalug, Busaban
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-11-2023
Subjects:
Actin
aging
Anti-inflammatory agents
Antioxidants
Cancer
Collagen
Cosmeceuticals
Cytoskeleton
Drug delivery
Economic importance
Electric fields
Electrospraying
Entrapment
Ethanol
Fourier transforms
Fruits
Hyaluronic acid
Identification and classification
Inflammation
Kinases
Leaves
mangiferin
Mango
mango leaves
Mangoes
Materia medica, Vegetable
Membranes
Nanoparticles
Phenols
Plant extracts
Properties
Proteins
Proteomics
Skin
Thailand
United States > US
Germany
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Summary:Mango (Mangifera indica L.) is one of the most economically important fruits in Thailand. Mango has been used as a traditional medicine because it possesses many biological activities, such as antioxidant properties, anti-inflammatory properties, microorganism-growth inhibition, etc. Among its natural pharmacologically active compounds, mangiferin is the main active component found in mango leaves. Mangiferin has the potential to treat a variety of diseases due to its multifunctional activities. This study aims to prepare a mangiferin-rich extract (MRE) from mango leaves and develop nanoparticles containing the MRE using an electrospraying technique to apply it in a cosmeceutical formulation. The potential cosmeceutical mechanisms of the MRE were investigated using proteomic analysis. The MRE is involved in actin-filament organization, the positive regulation of cytoskeleton organization, etc. Moreover, the related mechanism to its cosmeceutical activity is metalloenzyme-activity regulation. Nanoparticles were prepared from 0.8% w/v MRE and 2% w/v Eudragit® L100 solution using an electrospraying process. The mean size of the MRE-loaded nanoparticles (MNPs) received was 247.8 nm, with a PDI 0.271. The MRE entrapment by the process was quantified as 84.9%, indicating a high encapsulation efficiency. For the skin-retention study, the mangiferin content in the MNP-containing emulsion-gel membranes was examined and found to be greater than in the membranes of the MRE solution, illustrating that the MNPs produced by the electrospraying technique help transdermal delivery for cosmetic applications.
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ISSN:2079-4991
2079-4991
DOI:10.3390/nano13222931