Search Results - "Sirakanyan, Samvel N"

Benzothiazole and Chromone Derivatives as Potential ATR Kinase Inhibitors and Anticancer Agents by Frasinyuk, Mykhaylo, Chhabria, Dimple, Kartsev, Victor, Dilip, Haritha, Sirakanyan, Samvel N., Kirubakaran, Sivapriya, Petrou, Anthi, Geronikaki, Athina, Spinelli, Domenico

“…Despite extensive studies and the great variety of existing anticancer agents, cancer treatment remains an aggravating and challenging problem. Therefore, the…”
Get full text

New Bicyclic Pyridine-Based Hybrids Linked to the 1,2,3-Triazole Unit: Synthesis via Click Reaction and Evaluation of Neurotropic Activity and Molecular Docking by Sirakanyan, Samvel N, Spinelli, Domenico, Petrou, Anthi, Geronikaki, Athina, Kartsev, Victor G, Hakobyan, Elmira K, Yegoryan, Hasmik A, Zuppiroli, Luca, Zuppiroli, Riccardo, Ayvazyan, Armen G, Paronikyan, Ruzanna G, Arakelyan, Tatevik A, Hovakimyan, Anush A

“…The synthesis of new original bicyclic pyridine-based hybrids linked to the 1,2,3-triazole unit was described via a click reaction. The anticonvulsant activity…”
Get full text

Synthesis and Neurotropic Activity of New Heterocyclic Systems: Pyridofuro[3,2-d]pyrrolo[1,2-a]pyrimidines, Pyridofuro[3,2-d]pyrido[1,2-a]pyrimidines and Pyridofuro[3′,2′:4,5]pyrimido[1,2-a]azepines by Sirakanyan, Samvel N., Spinelli, Domenico, Geronikaki, Athina, Kartsev, Victor, Hakobyan, Elmira K., Petrou, Anthi, Paronikyan, Ruzanna G., Nazaryan, Ivetta M., Akopyan, Hasmik H., Hovakimyan, Anush A.

“…Background: Neurotic disturbances, anxiety, neurosis-like disorders, and stress situations are widespread. Benzodiazepine tranquillizers have been found to be…”
Get full text

Synthesis of 1-Amino-3-oxo-2,7-naphthyridines via Smiles Rearrangement: A New Approach in the Field of Chemistry of Heterocyclic Compounds by Sirakanyan, Samvel N, Spinelli, Domenico, Geronikaki, Athina, Zuppiroli, Luca, Zuppiroli, Riccardo, Kartsev, Victor G, Hakobyan, Elmira K, Yegoryan, Hasmik A, Hovakimyan, Anush A

“…In this paper we describe an efficient method for the synthesis of new heterocyclic systems: furo[2,3- ]-2,7-naphthyridines , as well as a new method for the…”
Get full text

Synthesis, Antitumor Activity, and Docking Analysis of New Pyrido[3',2':4,5]furo(thieno)[3,2- d ]pyrimidin-8-amines by Sirakanyan, Samvel N, Spinelli, Domenico, Geronikaki, Athina, Hakobyan, Elmira K, Sahakyan, Harutyun, Arabyan, Erik, Zakaryan, Hovakim, Nersesyan, Lusine E, Aharonyan, Anahit S, Danielyan, Irina S, Muradyan, Rafayel E, Hovakimyan, Anush A

“…Continuing our research in the field of new heterocyclic compounds, herein we report on the synthesis and antitumor activity of new amino derivatives of…”
Get full text

Synthesis and antimicrobial activity of new amino derivatives of pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine by Sirakanyan, Samvel N, Geronikaki, Athina, Spinelli, Domenico, Hakobyan, Elmira K, Kartsev, Viktor G, Petrou, Anthi, Hovakimyan, Anush A

“…Annulated thienopyrimidine derivatives attracted big interest of the scientific community due to their broad spectrum of biological activities among which are…”
Get full text

New triazole-based hybrids as neurotropic agents by Sirakanyan, Samvel N, Spinelli, Domenico, Geronikaki, Athina, Hakobyan, Elmira K, Petrou, Anti, Kartsev, Victor G, Yegoryan, Hasmik A, Paronikyan, Ervand G, Zuppiroli, Luca, Jughetsyan, Hasmik V, Paronikyan, Ruzanna G, Arakelyan, Tatevik A, Hovakimyan, Anush A

“…Herein, we describe the synthesis of new hybrids linked to 1,2,3- and 1,2,4-triazole units. Hybrids connected to a 1,2,3-triazole ring were synthesized using…”
Get full text

Synthesis and antimicrobial activity of new derivatives of pyrano[4'',3'':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine and new heterocyclic systems by Sirakanyan, Samvel N., Spinelli, Domenico, Geronikaki, Athina, Kartsev, Viktor G., Hakobyan, Elmira K., Hovakimyan, Anush A.

“…Taking into account previously obtained biological results on some polyheterocyclic compounds (containing different heteroatoms) and in particular on several…”
Get full text

Synthesis of 3,3-dimethyl-6-oxopyrano[3,4-c]pyridines and their antiplatelet and vasodilatory activity by Sirakanyan, Samvel N, Hrubša, Marcel, Spinelli, Domenico, Dias, Patrícia, Kartsev, Victor, Carazo, Alejandro, Hovakimyan, Anush A, Pourová, Jana, Hakobyan, Elmira K, Karlíčková, Jana, Parvin, Shamima, Fadraersada, Jaka, Macáková, Kateřina, Geronikaki, Athina, Mladěnka, Přemysl

“…Abstract Objectives Both pyridine and pyrano derivatives have been previously shown to possess biologically relevant activity. In this study, we report the…”
Get full text

In silico Design, Synthesis and Biological Evaluation of Novel Thieno[3,2‐d]pyrimidine Derivatives for Cancer Therapy – A Preliminary Study on the Inhibitory Potential towards ATR Kinase Domain and PIKK Family by Sirakanyan, Samvel N., Dilip, Haritha, Geronikaki, Athina, Spinelli, Domenico, Kirubakaran, Sivapriya, Petrou, Anthi, Hakobyan, Elmira K., Kartsev, Victor G., Paronikyan, Ervand G., Yegoryan, Hasmik A., Yermalovyan, Lilit V., Hovakimyan, Anush A.

“…Continuing our studies in the field of new heterocyclic compounds with biological interest, herein we report the synthesis and anticancer activity of new N‐…”
Get full text

New heterocyclic systems: Pyrido[2′,3′:5,4]thieno(furo)[3,2-d]oxazines as intermediate compounds for the synthesis of substituted pyrido[3′,2′:4,5]thieno(furo)[3,2-d]pyrimidines by Sirakanyan, Samvel N., Spinelli, Domenico, Geronikaki, Athina, Hakobyan, Elmira K., Hovakimyan, Anush A.

“…Starting from the ethyl 1-aminothieno(furo)[2,3-b]pyridine-2-carboxylates 1 by alkaline hydrolysis the corresponding potassium salts of…”
Get full text

New Methods for the Synthesis of 3‐Amino‐6,7‐Dihydro‐5H‐Cyclopenta[c]Pyridine‐4‐Carbonitriles and Cyclopenta[d]Pyrazolo[3,4‐b]Pyridines via a Smiles‐type Rearrangement by Sirakanyan, Samvel N., Spinelli, Domenico, Geronikaki, Athina, Hovakimyan, Anush A.

“…By reaction with sodium ethoxide and as a function of their structures, 2‐[(1‐alkyl(aryl)‐4‐cyano‐6,7‐dihydro‐5H‐cyclopenta[c]pyridin‐3‐yl)oxy]acetamides 11…”
Get full text

New heterocyclic systems derived from pyridine: new substrates for the investigation of the azide/tetrazole equilibrium by Sirakanyan, Samvel N., Spinelli, Domenico, Geronikaki, Athina, Hovakimyan, Anush A., Noravyan, Azat S.

“…By exploiting the reactivity of 7-alkyl-3-chloro-4-cyano-1-hydrazino-5,6,7,8-tetrahydro-2,7-naphthyridines 5 some…”
Get full text

Synthesis and structure of condensed triazolo- and tetrazolopyrimidines by Sirakanyan, Samvel N., Geronikaki, Athina, Spinelli, Domenico, Hovakimyan, Anush A., Noravyan, Azat S.

“…Herein we present the synthesis of several new hydrazino derivatives of cyclopenta[c]pyridine, 5,6,7,8-tetrahydroisoquinoline and pyrano[3,4-c]pyridine from…”
Get full text

Synthesis and antimicrobial evaluation of novel polyheterocyclic systems derived from cyclopenta[4',5']pyrido[3',2':4,5]furo[3,2-d]pyrimidine by Sirakanyan, Samvel N., Spinelli, Domenico, Geronikaki, Athina, Kartsev, Victor G., Stepanyan, Hrachya M., Hakobyan, Elmira K., Hovakimyan, Anush A.

“…The synthesis of new cyclopenta[4',5']pyrido[3',2':4,5]furo[3,2- d ]pyrimidin-7-amines have been carried out to study their antimicrobial activity. The…”
Get full text

On the reactivity of 4-cyano-1,3-dichloro-7-methyl-5,6,7,8-tetrahydro-2,7-naphthyridine with several amines in different experimental conditions: monosubstitution, disubstitution, and a new unexpected rearrangement by Sirakanyan, Samvel N., Kartsev, Viktor G., Spinelli, Domenico, Geronikaki, Athina, Noravyan, Azat S., Hovakimyan, Anush A., Panosyan, Henrik A., Ayvazyan, Armen G., Tamazyan, Rafael A.

“…The reactivity of 4-cyano-1,3-dichloro-7-methyl-5,6,7,8-tetrahydro-2,7-naphthyridine 1 with nucleophiles has been investigated. The different reactivity of the…”
Get full text

On the reactivity of pyrido[3′,2′:4,5]furo(thieno)[3,2-d]pyrimidin-7(8)-ones with some alkyl mono- and di-halides: synthesis of new heterocyclic systems containing thiazolo[3,2-a]pyrimidine and pyrimido[2,1-b]thiazine moiety by Sirakanyan, Samvel N., Spinelli, Domenico, Geronikaki, Athina, Hovakimyan, Anush A.

“…Ethyl 1-aminofuro(thieno)[2,3-b]pyridine-2-carboxylates 1 reacted with benzoyl isothiocyanate and gave the relevant thioureido derivatives 2, whose…”
Get full text

Synthesis and Rearrangement of New 1,3-Diamino-2,7-naphthyridines and 1-Amino-3-oxo-2,7-naphthyridines by Sirakanyan, Samvel N., Spinelli, Domenico, Mattioli, Edoardo Jun, Calvaresi, Matteo, Geronikaki, Athina, Kartsev, Victor G., Hakobyan, Elmira K., Yegoryan, Hasmik A., Jughetsyan, Hasmik V., Manukyan, Mariam E., Hovakimyan, Anush A.

“…Herein we describe the synthesis and rearrangement of 1,3-diamino-2,7-naphthyridines and 1-amino-3-oxo-2,7-naphthyridines. In the case of…”
Get full text

Synthesis and structure of a new heterocyclic system: pyrido[3′,2′:4,5]furo[3,2-d][1,2,4]triazolo[4,3-a]pyrimidin-7(8)-one by Sirakanyan, Samvel N., Spinelli, Domenico, Geronikaki, Athina, Kartsev, Viktor G., Hakobyan, Elmira K., Hovakimyan, Anush A.

“…[Display omitted] •Synthesis of new heterocycles by intramolecular cyclization.•Triazole annulation by action of formic acid or its derivative.•Structure…”
Get full text

In silico Design, Synthesis and Biological Evaluation of Novel Thienopyrimidine Derivatives for Cancer Therapy – A Preliminary Study on the Inhibitory Potential towards ATR Kinase Domain and PIKK Family by Sirakanyan, Samvel N, Haritha Dilip, Geronikaki, Athina, Spinelli, Domenico, Sivapriya Kirubakaran, Petrou, Anthi, Hakobyan, Elmira K, Kartsev, Victor G, Paronikyan, Ervand G, Yegoryan, Hasmik A, Yermalovyan, Lilit V, Hovakimyan, Anush A

“…Continuing our studies in the field of new heterocyclic compounds with biological interest, herein we report the synthesis and anticancer activity of new N‐…”
Get full text