Development of 99mTc-SDP-choline SPECT radiopharmaceutical for imaging of cerebrovascular diseases

Cerebrovascular diseases are known as serious public health problem worldwide, which can be addressed more precisely through molecular imaging of non-functional brain cells. CDP-choline is an active cerebrovascular chemotherapeutic agent that can be used for diagnosis of cerebrovascular diseases pos...

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Bibliographic Details
Published in:	Pakistan journal of pharmaceutical sciences Vol. 33; no. 1(Supplementary); p. 241
Main Authors:	Rasheed, Rashid, Raza Naqvi, Syed Ali, Siraj, Rida, Aslam, Nosheen, Nasir, Muhammad Waqas, Abbas, Ali, Yaseen, Muhammad, Qaddus, Abdul, Roohi, Samina
Format:	Journal Article
Language:	English
Published:	Pakistan 01-01-2020
Subjects:	Cerebrovascular Disorders - diagnostic imaging Cerebrovascular Disorders - metabolism Choline - metabolism Cytidine Diphosphate - metabolism Humans Organotechnetium Compounds - metabolism Tissue Distribution - physiology Tomography, Emission-Computed, Single-Photon - methods Tomography, Emission-Computed, Single-Photon - trends
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Summary:	Cerebrovascular diseases are known as serious public health problem worldwide, which can be addressed more precisely through molecular imaging of non-functional brain cells. CDP-choline is an active cerebrovascular chemotherapeutic agent that can be used for diagnosis of cerebrovascular diseases post radiolabeling with γ-emitter radioisotopes. In this study we developed Tc labeled CDP-choline for imaging of cerebrovascular diseases particularly alzheimer, stroke, and parkinson's diseases. The radiosynthesis reaction resulted 97.47±2.34% radiochemical with promising stability, that is, >95% up to 6 h in blood serum. The biodistribution study in healthy mice revealed non-accumulated uptake of radiochemical in key body organs; in brain it was 8.59±1.11% ID/g at 1h post-injection which washed-out leaving behind 0.87±0.61% ID/g at 24 h post-injection. The over-all data revealed the Tc-CDP-choline could be a good candidate for further imaging investigations in diseased animal model.
ISSN:	1011-601X
DOI:	10.36721/PJPS.2020.33.1.SUP.241-244.1