Search Results - "Siragy, Helmy"

Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/ PGC-1α pathway in diabetic kidney by Akhtar, Safia, Siragy, Helmy M

“…Abnormal mitochondrial biogenesis and function has been linked to multiple diseases including diabetes. Recently, we demonstrated the role of renal (Pro)renin…”
Get full text

High glucose induces podocyte injury via enhanced (pro)renin receptor-Wnt-β-catenin-snail signaling pathway by Li, Caixia, Siragy, Helmy M

“…(Pro)renin receptor (PRR) expression is upregulated in diabetes. We hypothesized that PRR contributes to podocyte injury via activation of Wnt-β-catenin-snail…”
Get full text

Renal Hypokalemia: An Endocrine Perspective by Culver, Silas A, Suleman, Nawar, Kavuru, Varun, Siragy, Helmy M

“…The majority of disorders that cause renal potassium wasting present with abnormalities in adrenal hormone secretion. While these findings frequently lead…”
Get full text

(Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose by Li, Caixia, Siragy, Helmy M

“…High glucose reduces autophagy and enhances apoptosis of podocytes. Previously, we reported that high glucose induced podocyte injury through upregulation of…”
Get more information

(Pro)renin receptor contributes to regulation of renal epithelial sodium channel by Quadri, Syed, Siragy, Helmy M

“…BACKGROUND:Recent studies reported increased (Pro)renin receptor (PRR) expression during low-salt intake. We hypothesized that PRR plays a role in regulation…”
Get full text

Angiotensin AT2 Receptor Stimulation Inhibits Early Renal Inflammation in Renovascular Hypertension by Matavelli, Luis C, Huang, Jiqian, Siragy, Helmy M

“…Angiotensin II type 2 receptor (AT2R) counteracts most effects of angiotensin II type 1 receptor (AT1R). We hypothesized that direct AT2R stimulation reduces…”
Get full text

AT2 Receptor Activities and Pathophysiological Implications by Matavelli, Luis C, Siragy, Helmy M

“…Although angiotensin II subtype-2 receptor (AT2R) was discovered over 2 decades ago, its contribution to physiology and pathophysiology is not fully…”
Get full text

Role of the intrarenal renin-angiotensin-aldosterone system in chronic kidney disease by Siragy, Helmy M, Carey, Robert M

“…The existence of local or tissue-based renin-angiotensin-aldosterone systems (RAAS) is well documented and has been implicated as a key player in the…”
Get more information

How I Approach It: Adrenal Insufficiency in Cirrhosis by Wentworth, Brian J., Henry, Zachary H., Siragy, Helmy M.

“…Cholesterol is delivered to the adrenal gland by hepatic-derived high-density lipoprotein (HDL); is transported across the mitochondrial membrane; and…”
Get full text

Novel regulation of renal gluconeogenesis by Atp6ap2 in response to high fat diet via PGC1-α/AKT-1 pathway by Akhtar, Safia, Culver, Silas A., Siragy, Helmy M.

“…Recent studies suggested that renal gluconeogenesis is substantially stimulated in the kidney in presence of obesity. However, the mechanisms responsible for…”
Get full text

Intrarenal Angiotensin-Converting Enzyme: the Old and the New by Culver, Silas, Li, Caixia, Siragy, Helmy M.

“…Purpose of Review The intrarenal renin-angiotensin-aldosterone system (RAS) is an independent paracrine hormonal system with an increasingly prominent role in…”
Get full text

S1266 Elevated Interleukin-6 Activity Is Associated With Adrenal Insufficiency in Outpatients With Decompensated Cirrhosis by Geng, Calvin X., Wentworth, Brian J., Siragy, Helmy, Henry, Zachary

Get full text

Autophagy upregulates (pro)renin receptor expression via reduction of P62/SQSTM1 and activation of ERK1/2 signaling pathway in podocytes by Li, Caixia, Siragy, Helmy M

“…Autophagy plays a major role in podocytes health and disease. P62, also known as sequestosome-1 (SQSTM1), is a marker for autophagic activity and is required…”
Get more information

Glucose Promotes the Production of Interleukine-1β and Cyclooxygenase-2 in Mesangial Cells via Enhanced (Pro)Renin Receptor Expression by Huang, Jiqian, Siragy, Helmy M

“…(Pro)renin receptor (PRR) is present in renal glomeruli, and its expression is up-regulated in diabetes. Similarly, renal inflammation is increased in the…”
Get full text

(Pro)renin receptor contributes to renal mitochondria dysfunction, apoptosis and fibrosis in diabetic mice by Li, Caixia, Matavelli, Luis C., Akhtar, Safia, Siragy, Helmy M.

“…Recently we demonstrated that increased renal (Pro)renin receptor (PRR) expression in diabetes contributes to development of diabetic kidney disease. However,…”
Get full text

S1527 Adrenal Dysfunction Does Not Predict Increased Rates of Portal Hypertension-Related Decompensation in Outpatients With Decompensated Cirrhosis by Geng, Calvin X., Kadiyala, Jagannath, Siragy, Helmy, Henry, Zachary, Wentworth, Brian J.

“…Baseline characteristics including age, sex, comorbidity index, and MELD were similar (Table 1). Analysis of Patients with and without Adrenal Dysfunction No…”
Get full text

Author's reply: Plasma corticosteroid‐binding globulin levels in cirrhosis by Wentworth, Brian J., Schliep, Matthew, Siragy, Helmy M., Henry, Zachary H.

Get full text

Relative adrenal insufficiency in the non‐critically ill patient with cirrhosis: A systematic review and meta‐analysis by Wentworth, Brian J., Schliep, Matthew, Novicoff, Wendy, Siragy, Helmy M., Geng, Calvin X., Henry, Zachary H.

“…Background & Aims Characterization of relative adrenal insufficiency (RAI) in cirrhosis is heterogeneous with regard to studied patient populations and…”
Get full text

Angiotensin Type-2 Receptors: Transducers of Natriuresis in the Renal Proximal Tubule by Carey, Robert M, Siragy, Helmy M, Gildea, John J, Keller, Susanna R

“…Angiotensin II (Ang II) type-2 receptors (AT R) are expressed in the adult kidney, prominently in renal proximal tubule cells (RPTCs), and play an important…”
Get full text

Sodium Depletion Enhances Renal Expression of (Pro)Renin Receptor via Cyclic GMP-Protein Kinase G Signaling Pathway by Huang, Jiqian, Siragy, Helmy M

“…(Pro)renin receptor (PRR) is expressed in renal vasculature, glomeruli, and tubules. The physiological regulation of this receptor is not well established. We…”
Get full text