Search Results - "Sirac Dilber, M"

Good manufacturing practice and clinical-grade human embryonic stem cell lines by Unger, Christian, Skottman, Heli, Blomberg, Pontus, Sirac Dilber, M., Hovatta, Outi

“…Human embryonic stem cell (hESC) lines, after directed differentiation, hold the greatest potential for cell transplantation treatment in many severe diseases…”
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Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components by Alici, Evren, Sutlu, Tolga, Björkstrand, Bo, Gilljam, Mari, Stellan, Birgitta, Nahi, Hareth, Quezada, Hernan Concha, Gahrton, Gösta, Ljunggren, Hans-Gustaf, Dilber, M. Sirac

“…Multiple myeloma (MM) is an incurable plasma cell malignancy with poor outcome. The most promising therapeutic options currently available are combinations of…”
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The derivation of clinical-grade human embryonic stem cell lines by Skottman, Heli, Dilber, M. Sirac, Hovatta, Outi

“…The pluripotent nature of human embryonic stem cells (hESC) has attracted great interest in using them as a source of cells or tissue in cell therapy. However,…”
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NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy by Malmberg, Karl-Johan, Bryceson, Yenan T., Carlsten, Mattias, Andersson, Sandra, Björklund, Andreas, Björkström, Niklas K., Baumann, Bettina C., Fauriat, Cyril, Alici, Evren, Dilber, M. Sirac, Ljunggren, Hans-Gustaf

“…Insights into the molecular basis for natural killer (NK) cell recognition of human cancer have been obtained in recent years. Here, we review current…”
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TK.007: A novel, codon-optimized HSVtk(A168H) mutant for suicide gene therapy by Preuss, Ellen, Treschow, Alexandra, Newrzela, Sebastian, Brücher, Daniela, Weber, Kristoffer, Felldin, Ulrika, Alici, Evren, Gahrton, Gösta, von Laer, Dorothee, Dilber, M Sirac, Fehse, Boris

“…Conditional elimination of infused gene-modified alloreactive T cells, using suicide gene activation, has been shown to be an efficient strategy to abrogate…”
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Retroviral gene transfer into primary human natural killer cells by Alici, Evren, Sutlu, Tolga, Sirac Dilber, M

“…Modulation of intracellular signaling pathways or receptor expression in natural killer (NK) cells by genetic manipulation is an attractive possibility in…”
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A murine model of acute myeloid leukemia with Evi1 overexpression and autocrine stimulation by an intracellular form of GM-CSF in DA-3 cells by Cardona, Maria E., Simonson, Oscar E., Oprea, Iulian I., Moreno, Pedro M. D., Silva-Lara, Maria F., Mohamed, Abdalla J., Christensson, Birger, Gahrton, Gösta, Dilber, M. Sirac, Smith, C. I. Edvard, Arteaga, H. Jose

“…The poor treatment response of acute myeloid leukemia (AML) overexpressing high-risk oncogenes such as EVI1, demands specific animal models for new treatment…”
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Safety analysis of ex vivo-expanded NK and NK-like T cells administered to cancer patients: a phase I clinical study by Barkholt, Lisbeth, Alici, Evren, Conrad, Reka, Sutlu, Tolga, Gilljam, Mari, Stellan, Birgitta, Christensson, Birger, Guven, Hayrettin, Björkström, Niklas K, Söderdahl, Gunnar, Cederlund, Kerstin, Kimby, Eva, Aschan, Johan, Ringdén, Olle, Ljunggren, Hans-Gustaf, Dilber, M Sirac

“…The chimeric state after allogeneic hematopoietic stem cell transplantation provides a platform for adoptive immunotherapy using donor-derived immune cells…”
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Anti-myeloma activity of endogenous and adoptively transferred activated natural killer cells in experimental multiple myeloma model by Alici, Evren, Konstantinidis, Kyriakos V, Sutlu, Tolga, Aints, Alar, Gahrton, Gösta, Ljunggren, Hans-Gustaf, Dilber, M. Sirac

“…Objective Despite advances in autologous stem cell transplantation and chemotherapy, multiple myeloma (MM) remains an incurable disease. Due to the role of…”
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Lentiviral‐Mediated HoxB4 Expression in Human Embryonic Stem Cells Initiates Early Hematopoiesis in a Dose‐Dependent Manner but Does Not Promote Myeloid Differentiation by Unger, Christian, Kärner, Elerin, Treschow, Alexandra, Stellan, Birgitta, Felldin, Ulrika, Concha, Hernan, Wendel, Mikael, Hovatta, Outi, Aints, Alar, Ährlund‐Richter, Lars, Dilber, M. Sirac

“…The variation of HoxB4 expression levels might be a key regulatory mechanism in the differentiation of human embryonic stem cell (hESC)‐derived hematopoietic…”
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Differentiation of human embryonic stem cells into osteogenic or hematopoietic lineages: A dose-dependent effect of osterix over-expression by Kärner, Elerin, Unger, Christian, Cerny, Radim, Ährlund-Richter, Lars, Ganss, Bernhard, Dilber, M. Sirac, Wendel, Mikael

“…Enhanced differentiation of human embryonic stem cells (HESCs), induced by genetic modification could potentially generate a vast number of diverse cell types…”
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Efficient gene transfer into primary human natural killer cells by retroviral transduction by Guven, Hayrettin, Konstantinidis, Kyriakos V., Alici, Evren, Aints, Alar, Abedi-Valugerdi, Manuchehr, Christensson, Birger, Ljunggren, Hans-Gustaf, Dilber, M. Sirac

“…To optimize retroviral gene transfer into primary human natural killer (NK) cells. NK cells from healthy donors were expanded ex vivo for a period of 21 days…”
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Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene by Asklund, Thomas, Appelskog, Ioulia B, Ammerpohl, Ole, Langmoen, Iver A, Dilber, M Sirac, Aints, Alar, Ekström, Tomas J, Almqvist, Per M

“…The ability of herpes simplex virus type 1 thymidine kinase (HSV-tk)-expressing cells incubated with ganciclovir (GCV) to induce cytotoxicity in neighboring…”
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Targeting IL-2 to the endoplasmic reticulum confines autocrine growth stimulation to NK-92 cells by Konstantinidis, Kyriakos V., Alici, Evren, Aints, Alar, Christensson, Birger, Ljunggren, Hans-Gustaf, Dilber, M. Sirac

“…Anti-tumor effects mediated by adoptively transferred natural killer (NK) cells are dependent on the presence of interleukin-2 (IL-2). IL-2 is considered to be…”
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Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo by DILBER, M. S, ABEDI, M. R, CHRISTENSSON, B, BJÖRKSTRAND, B, KIDDER, G. M, NAUS, C. C. G, GAHRTON, G, SMITH, C. I. E

“…Transfer of the herpes simplex thymidine kinase gene (HSVtk) into tumor cells followed by the administration of ganciclovir (GCV) provides a potential strategy…”
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Visualization of 5T33 myeloma cells in the C57BL/KaLwRij mouse: establishment of a new syngeneic murine model of multiple myeloma by Alici, Evren, Konstantinidis, Kyriakos V., Aints, Alar, Dilber, M. Sirac, Abedi-Valugerdi, Manuchehr

“…Lack of good models for in vivo detection of multiple myeloma (MM) cells hampers our understanding of the disease. Our objective was to establish a murine…”
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Derivation of human skin fibroblast lines for feeder cells of human embryonic stem cells by Unger, Christian, Felldin, Ulrika, Nordenskjöld, Agneta, Dilber, M Sirac, Hovatta, Outi

“…After the first derivations of human embryonic stem cell (hESC) lines on fetal mouse feeder cell layers, the idea of using human cells instead of mouse cells…”
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Choosing CCR5 or Rev siRNA in HIV-1 by Arteaga, H. Jose, Hinkula, Jorma, van Dijk-Härd, Iris, Dilber, M. Sirac, Wahren, Britta, Christensson, Birger, Mohamed, Abdalla J, Edvard Smith, C. I

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Intercellular spread of GFP-VP22 by Aints, Alar, Dilber, M. Sirac, Smith, C. I. Edvard

“…Background The herpes simplex virus type 1 (HSV‐1) VP22 polypeptide has been reported to mediate intercellular trafficking of heterologous proteins fused to…”
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Enhanced ouabain resistance gene as a eukaryotic selection marker by Aints, Alar, Belusa, Roger, Andersson, Ronnie M, Güven, Hayrettin, Dilber, M Sirac

“…Current selection markers allow selection by antibiotics or fluorescent/magnetic sorting by green fluorescent protein or membrane antigens. Antibiotic…”
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