Ilex paraguariensis: Potential antioxidant on aluminium toxicity, in an experimental model of Alzheimer's disease

Ilex paraguariensis: Potential antioxidant on aluminium toxicity, in an experimental model of Alzheimer's disease

Ilex paraguariensis, yerba mate is a native plant from the southern region of Brazil. Studies showed that yerba mate has an antioxidant potential, which could help to reduce the risk of developing neurodegenerative diseases, as Alzheimer's Disease (AD). It's known that I. paraguariensis gr...

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Bibliographic Details
Published in:Journal of inorganic biochemistry Vol. 181; pp. 104 - 110
Main Authors: Bortoli, Pâmela M., Alves, Carla, Costa, Eduarda, Vanin, Ana Paula, Sofiatti, Jéssica R., Siqueira, Diego P., Dallago, Rogério M., Treichel, Helen, Vargas, Gean Delise L.P., Kaizer, Rosilene R.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-04-2018
Subjects:
Acetylcholinesterase
Antioxidants
C. elegans
Neurodegeneratives diseases
Worms
Yerba mate
Antioxidants
C. elegans
Neurodegeneratives diseases
Yerba mate
Acetylcholinesterase
Worms
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Summary:Ilex paraguariensis, yerba mate is a native plant from the southern region of Brazil. Studies showed that yerba mate has an antioxidant potential, which could help to reduce the risk of developing neurodegenerative diseases, as Alzheimer's Disease (AD). It's known that I. paraguariensis grows in acid soils with aluminium (Al), which is bioavailable in these soils. Al has a neurotoxic potential related with the progression of neurological disorders. This study aim was to evaluate the potential of I. paraguariensis in the etiology of AD using strains of Caenorhabditis elegans and the concentration of Al and antioxidants in the yerba mate extract. The results of the I. paraguariensis infusions made at 65°C and at 75° C show that there was no significant difference between both temperatures when preparing the tea infusion in relation to the presence of Al, methylxanthines, phenolic compounds and flavonoids. Additionally, in the case of Al, there was no difference between the extracts prepared at both temperatures. The behavioral parameters of C. elegans were altered after a long-term exposure to both factors: I. paraguariensis extract and Al. Through the antioxidant levels results along with the Al content on the Acetylcholinesterase (AChE) activity it is possible to observe that the acute and chronic exposure to Al and I. paraguariensis leaves extract are very similar to wild-type worms. Moreover, we can observe that the results in both the transgenic strains long-term exposed to I. paraguariensis leaves extract and to the Al concentrations presented an increase in the AChE activity. [Display omitted] •Aluminium levels are present in the I. paraguariensis extract.•I. paraguariensis infusion modifies the cholinergic nervous system in worms with AD.•Al elicits the AD characteristics in AD-related transgenic strain worms of C. elegans.•Al-induced activation of acetylcholinesterase activity in transgenic strains of worms.•The Al has inhibitory role on the cholinergic system and behavior.
ISSN:0162-0134
1873-3344
DOI:10.1016/j.jinorgbio.2017.11.001