Ipsilateral breast recurrence after breast conserving surgery in patients with small (≤2 cm) breast cancer treated with modern adjuvant therapies

Ipsilateral breast recurrence after breast conserving surgery in patients with small (≤2 cm) breast cancer treated with modern adjuvant therapies

Abstract Background Modern multimodality treatment greatly influences the rate and the predictive factors for ipsilateral cancer recurrence (IBR) after breast conserving surgery. Material and nethods The study is based on 1297 patients with pT1 breast cancer and treated with breast conserving surger...

Full description

Saved in:
Bibliographic Details
Published in:European journal of surgical oncology Vol. 37; no. 1; pp. 25 - 31
Main Authors: Siponen, E.T, Vaalavirta, L, Joensuu, H, Vironen, J, Heikkilä, P, Leidenius, M.H.K
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-01-2011
WB Saunders
Subjects:
Adult
Aged
Breast cancer
Breast conserving surgery
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Combined Modality Therapy
Female
Hematology, Oncology and Palliative Medicine
Humans
Local recurrence
Mastectomy, Segmental
Middle Aged
Neoplasm Recurrence, Local
Radiotherapy
Radiotherapy, Adjuvant
Risk Factors
Surgery
Breast conserving surgery
Breast cancer
Radiotherapy
Local recurrence
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Modern multimodality treatment greatly influences the rate and the predictive factors for ipsilateral cancer recurrence (IBR) after breast conserving surgery. Material and nethods The study is based on 1297 patients with pT1 breast cancer and treated with breast conserving surgery in February 2001–August 2005. The median duration of follow-up was 57 months. Results IBR occurred in 27 (2.1%) patients. It was located in the quadrant of prior breast resection in 17 (63%) cases. The median time to an IBR was 41 months (range, 6–78) regardless of whether the recurrence was located in the same or in another quadrant. Omission of radiotherapy was associated with a higher IBR incidence, HR 10,344 (95% CI 1904–56,184; p = 0.007). The IBRs occurred particularly often, in 27% of the 11 patients who refused radiotherapy. Patients diagnosed with ER+ cancer had a lower risk of IBR when compared with those with ER−/HER2+ cancer, HR 0.215 (95% CI 0.049–0.935; p = 0.040). Conclusions The risk of IBR was low during the first 5 years after breast resection among patients with pT1 breast cancer and treated with modern surgical and adjuvant therapies. The majority IBRs still occur at or close to the prior resection site underlining the importance of local therapies. Omission of radiotherapy was the most significant risk factor for IBR.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2010.11.003