Search Results - "Sipkins, Dorothy A"

Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy by Boyerinas, Benjamin, Zafrir, Maya, Yesilkanal, Ali E., Price, Trevor T., Hyjek, Elizabeth M., Sipkins, Dorothy A.

“…Malignant cells may evade death from cytotoxic agents if they are in a dormant state. The host microenvironment plays important roles in cancer progression,…”
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Rewiring the Niche: Sympathetic Neuropathy Drives Malignant Niche Transformation by Price, Trevor, Sipkins, Dorothy A.

“…In recent years, it has become increasingly evident that hematological malignancies can alter their microenvironment, but the therapeutic implications of these…”
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Leukaemia: a model metastatic disease by Whiteley, Andrew E., Price, Trevor T., Cantelli, Gaia, Sipkins, Dorothy A.

“…In contrast to solid cancers, which often require genetic modifications and complex cellular reprogramming for effective metastatic dissemination, leukaemic…”
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E-Selectin and SDF-1 regulate metastatic trafficking of breast cancer cells within the bone by Price, Trevor T., Sipkins, Dorothy A.

“…E-selectin is a key mediator of breast cancer cell (BCC) metastatic entry into the bone and stromal-derived factor 1 (SDF-1) is a critical molecular anchor for…”
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Leukaemia hijacks a neural mechanism to invade the central nervous system by Yao, Hisayuki, Price, Trevor T., Cantelli, Gaia, Ngo, Brandon, Warner, Matthew J., Olivere, Lindsey, Ridge, Sarah M., Jablonski, Elizabeth M., Therrien, Joseph, Tannheimer, Stacey, McCall, Chad M., Chenn, Anjen, Sipkins, Dorothy A.

“…Acute lymphoblastic leukaemia (ALL) has a marked propensity to metastasize to the central nervous system (CNS). In contrast to brain metastases from solid…”
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Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells by Colmone, Angela, Amorim, Maria, Pontier, Andrea L., Wang, Sheng, Jablonski, Elizabeth, Sipkins, Dorothy A.

“…The host tissue microenvironment influences malignant cell proliferation and metastasis, but little is known about how tumor-induced changes in the…”
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Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone by Price, Trevor T, Burness, Monika L, Sivan, Ayelet, Warner, Matthew J, Cheng, Renee, Lee, Clara H, Olivere, Lindsey, Comatas, Karrie, Magnani, John, Kim Lyerly, H, Cheng, Qing, McCall, Chad M, Sipkins, Dorothy A

“…Breast cancer metastatic relapse can occur years after therapy, indicating that disseminated breast cancer cells (BCCs) have a prolonged dormant phase before…”
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Salting the Soil: Targeting the Microenvironment of Brain Metastases by Srinivasan, Ethan S, Tan, Aaron C, Anders, Carey K, Pendergast, Ann Marie, Sipkins, Dorothy A, Ashley, David M, Fecci, Peter E, Khasraw, Mustafa

“…Paget's "seed and soil" hypothesis of metastatic spread has acted as a foundation of the field for over a century, with continued evolution as mechanisms of…”
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Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis by Whiteley, Andrew E, Ma, Danhui, Wang, Lihua, Yu, Seok-Yeong, Yin, Claire, Price, Trevor T, Simon, Brennan G, Xu, Katie R, Marsh, Kathleen A, Brockman, Maegan L, Prioleau, Tatiana M, Zhou, Katherine I, Cui, Xiuyu, Fecci, Peter E, Jeck, William R, McCall, Chad M, Neff, Jadee L, Sipkins, Dorothy A

“…The molecular mechanisms that regulate breast cancer cell (BCC) metastasis and proliferation within the leptomeninges (LM) are poorly understood, which limits…”
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Real-time Detection of Circulating Apoptotic Cells by in Vivo Flow Cytometry by Wei, Xunbin, Sipkins, Dorothy A., Pitsillides, Costas M., Novak, John, Georgakoudi, Irene, Lin, Charles P.

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In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment by Sipkins, Dorothy A, Lin, Charles P, Wei, Xunbin, Wu, Juwell W, Runnels, Judith M, Côté, Daniel, Means, Terry K, Luster, Andrew D, Scadden, David T

“…The organization of cellular niches is known to have a key role in regulating normal stem cell differentiation and regeneration, but relatively little is known…”
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The stem cell niche in health and malignancy by Burness, Monika L, Sipkins, Dorothy A

“…Abstract Somatic stem cells play a well-defined and important role in tissue renewal. Their malignant counterparts, cancer stem cells, are thought to be…”
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Rendering the Leukemia Cell Susceptible to Attack by Sipkins, Dorothy A

“…In mice, short-term treatment with interferon-α pushes dormant hematopoietic stem cells into a state of proliferation. This finding may be relevant to the…”
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Pan-PI3Ki targets multiple B-ALL microenvironment interactions that fuel systemic and CNS relapse by Ridge, Sarah M., Whiteley, Andrew E., Yao, Hisayuki, Price, Trevor T., Brockman, Maegan L., Murray, Andrew S., Simon, Brennan G., Islam, Prioty, Sipkins, Dorothy A.

“…The majority of adult patients with acute lymphoblastic leukemia (ALL) suffer relapse, and in patients with central nervous system (CNS) metastasis, prognosis…”
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HSPCs in the Balance: The Vascular Niche by Boyerinas, Benjamin, Sipkins, Dorothy A.

“…Recently, in Nature Cell Biology, Kobayashi et al. (2010) report that Akt-activated sinusoidal endothelial cells within the bone marrow modulate the…”
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Stem cell factor expression in B cell malignancies is influenced by the niche by Fox, Matthew F., Pontier, Andrea, Gurbuxani, Sandeep, Sipkins, Dorothy A.

“…Abstract Our group has previously demonstrated that expression of the cytokine stem cell factor (SCF) by leukemic blasts is a frequent finding in pre-B acute…”
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Beyond angiogenesis: the role of endothelium in the bone marrow vascular niche by Colmone, Angela, Sipkins, Dorothy A

“…Specific tissue microenvironments, or niches, are critical for homing and maintenance of both stem cells and tumor cells in vivo . Little is known, however,…”
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Chemotherapy and the bone marrow stroma by Sipkins, Dorothy A.

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ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging by Sipkins, Dorothy A, Gijbels, Koenraad, Tropper, François D, Bednarski, Mark, Li, King C.P, Steinman, Lawrence

“…The expression of leukocyte adhesion molecules in the intact brains of mice with experimental autoimmune encephalitis (EAE) was visualized by Magnetic…”
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Paramagnetic Polymerized Liposomes: Synthesis, Characterization, and Applications for Magnetic Resonance Imaging by Storrs, Richard W, Tropper, Francois D, Li, Henry Y, Song, Curtis K, Kuniyoshi, Jeremy K, Sipkins, Dorothy A, Li, King C. P, Bednarski, Mark D

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