Search Results - "Sipila, Sampsa"

GABA Uptake via GABA Transporter-1 Modulates GABAergic Transmission in the Immature Hippocampus by Sipila, Sampsa, Huttu, Kristiina, Voipio, Juha, Kaila, Kai

“…GABA uptake limits GABA actions during synaptic responses when the density of active release sites is high or multiple axons are synchronously activated. GABA…”
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Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis by Kaila, Kai, Schuchmann, Sebastian, Schmitz, Dietmar, Rivera, Claudio, Vanhatalo, Sampsa, Salmen, Benedikt, Mackie, Ken, Sipilä, Sampsa T, Voipio, Juha

“…Febrile seizures are frequent during early childhood, and prolonged (complex) febrile seizures are associated with an increased susceptibility to temporal lobe…”
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Compensatory Enhancement of Intrinsic Spiking upon NKCC1 Disruption in Neonatal Hippocampus by Sipila, Sampsa T, Huttu, Kristiina, Yamada, Junko, Afzalov, Ramil, Voipio, Juha, Blaesse, Peter, Kaila, Kai

“…Depolarizing and excitatory GABA actions are thought to be important in cortical development. We show here that GABA has no excitatory action on CA3 pyramidal…”
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The cation-chloride cotransporter NKCC1 promotes sharp waves in the neonatal rat hippocampus by Sipilä, Sampsa T., Schuchmann, Sebastian, Voipio, Juha, Yamada, Junko, Kaila, Kai

“…Earlier studies indicate a crucial role for the interconnected network of intrinsically bursting CA3 pyramidal neurons in the generation of in vivo hippocampal…”
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Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2 by Rivera, Claudio, Voipio, Juha, Thomas-Crusells, Judith, Li, Hong, Emri, Zsuzsa, Sipila, Sampsa, Payne, John A, Minichiello, Liliana, Saarma, Mart, Kaila, Kai

“…GABA-mediated fast-hyperpolarizing inhibition depends on extrusion of chloride by the neuron-specific K-Cl cotransporter, KCC2. Here we show that sustained…”
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Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability by Jacobs, Stefan, Ruusuvuori, Eva, Sipilä, Sampsa T, Haapanen, Aleksi, Damkier, Helle H, Kurth, Ingo, Hentschke, Moritz, Schweizer, Michaela, Rudhard, York, Laatikainen, Linda M, Tyynelä, Jaana, Praetorius, Jeppe, Voipio, Juha, Hübner, Christian A

“…Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. Here we report that disrupting the Slc4a10 gene, which…”
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Depolarizing GABA Acts on Intrinsically Bursting Pyramidal Neurons to Drive Giant Depolarizing Potentials in the Immature Hippocampus by Sipila, Sampsa T, Huttu, Kristiina, Soltesz, Ivan, Voipio, Juha, Kaila, Kai

“…Spontaneous periodic network events are a characteristic feature of developing neuronal networks, and they are thought to play a crucial role in the maturation…”
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Intrinsic bursting of immature CA3 pyramidal neurons and consequent giant depolarizing potentials are driven by a persistent Na+ current and terminated by a slow Ca2+-activated K+ current by Sipilä, Sampsa T., Huttu, Kristiina, Voipio, Juha, Kaila, Kai

“…The CA3 area of the mature hippocampus is known for its ability to generate intermittent network activity both in physiological and in pathological conditions…”
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Glycine transporter-1 controls nonsynaptic inhibitory actions of glycine receptors in the neonatal rat hippocampus by Sipilä, Sampsa T, Spoljaric, Albert, Virtanen, Mari A, Hiironniemi, Inkeri, Kaila, Kai

“…Although functional glycinergic synapses have not been identified in the hippocampus, neurons in this area express Cl(-) permeable extrasynaptic glycine…”
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GAT-1 acts to limit a tonic GABA(A) current in rat CA3 pyramidal neurons at birth by Sipilä, Sampsa T, Voipio, Juha, Kaila, Kai

“…Tonic activation of GABA(A) receptors takes place before the development of functional synapses in cortical structures. We studied whether inefficient GABA…”
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GAT-1 acts to limit a tonic GABA sub(A) current in rat CA3 pyramidal neurons at birth by Sipila, Sampsa T, Voipio, Juha, Kaila, Kai

“…Tonic activation of GABA sub(A) receptors takes place before the development of functional synapses in cortical structures. We studied whether inefficient GABA…”
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Decreasing incidence and improved survival of laryngeal cancer in Finland by Teppo, H, Koivunen, P, Sipilä, S, Jokinen, K, Hyrynkangas, K, Läärä, E, Pukkala, E, Sovio, U, Alho, O P

“…The decreasing incidence rate and improvement in survival of laryngeal cancer patients in Finland are exceptions among western countries. A descriptive study…”
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GAT-1 acts to limit a tonic GABAA current in rat CA3 pyramidal neurons at birth by Sipilä, Sampsa T., Voipio, Juha, Kaila, Kai

“…Tonic activation of GABAA receptors takes place before the development of functional synapses in cortical structures. We studied whether inefficient GABA…”
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GABAergic control of CA3-driven network events in the developing hippocampus by Sipilä, Sampsa T, Kaila, Kai

“…Endogenous activity is a characteristic feature of developing neuronal networks. In the neonatal rat hippocampus, spontaneously occurring network events known…”
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Intrinsic bursting of immature CA3 pyramidal neurons and consequent giant depolarizing potentials are driven by a persistent Na + current and terminated by a slow Ca 2+ ‐activated K + current by Sipilä, Sampsa T., Huttu, Kristiina, Voipio, Juha, Kaila, Kai

“…Abstract The CA3 area of the mature hippocampus is known for its ability to generate intermittent network activity both in physiological and in pathological…”
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Modulation of slow brain potentials by working memory load in spatial and nonspatial auditory tasks by Rämä, Pia, Paavilainen, Liisa, Anourova, Irina, Alho, Kimmo, Reinikainen, Kalevi, Sipilä, Sampsa, Carlson, Synnöve

“…Slow event-related brain potentials were recorded from the human scalp during spatial and nonspatial auditory delayed matching-to-sample and n-back tasks to…”
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