Search Results - "Sion, A"

Acute Hyperenergetic, High-Fat Feeding Increases Circulating FGF21, LECT2, and Fetuin-A in Healthy Men by Willis, Scott A, Sargeant, Jack A, Yates, Thomas, Takamura, Toshinari, Takayama, Hiroaki, Gupta, Vinay, Brittain, Emily, Crawford, Joe, Parry, Siôn A, Thackray, Alice E, Varela-Mato, Veronica, Stensel, David J, Woods, Rachel M, Hulston, Carl J, Aithal, Guruprasad P, King, James A

“…Hepatokines such as fibroblast growth factor 21 (FGF21), leukocyte cell-derived chemotaxin 2 (LECT2), fetuin-A, fetuin-B, and selenoprotein P (SeP) are…”
Get more information

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans by Patel, Satish, Alvarez-Guaita, Anna, Melvin, Audrey, Rimmington, Debra, Dattilo, Alessia, Miedzybrodzka, Emily L., Cimino, Irene, Maurin, Anne-Catherine, Roberts, Geoffrey P., Meek, Claire L., Virtue, Samuel, Sparks, Lauren M., Parsons, Stephanie A., Redman, Leanne M., Bray, George A., Liou, Alice P., Woods, Rachel M., Parry, Sion A., Jeppesen, Per B., Kolnes, Anders J., Harding, Heather P., Ron, David, Vidal-Puig, Antonio, Reimann, Frank, Gribble, Fiona M., Hulston, Carl J., Farooqi, I. Sadaf, Fafournoux, Pierre, Smith, Steven R., Jensen, Jorgen, Breen, Danna, Wu, Zhidan, Zhang, Bei B., Coll, Anthony P., Savage, David B., O’Rahilly, Stephen

“…GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest…”
Get full text

Short-term, high-fat overfeeding impairs glycaemic control but does not alter gut hormone responses to a mixed meal tolerance test in healthy, normal-weight individuals by Parry, Siôn A., Smith, Jennifer R., Corbett, Talitha R. B., Woods, Rachel M., Hulston, Carl J.

“…Obesity is undoubtedly caused by a chronic positive energy balance. However, the early metabolic and hormonal responses to overeating are poorly described…”
Get full text

Formulation of hydrophobic peptides for skin delivery via coated microneedles by Zhao, Xin, Coulman, Sion A., Hanna, Stephanie J., Wong, F. Susan, Dayan, Colin M., Birchall, James C.

“…Microneedles (MNs) have been investigated as a minimally-invasive delivery technology for a range of active pharmaceutical ingredients (APIs). Various…”
Get full text

Microneedle delivery of plasmid DNA to living human skin: Formulation coating, skin insertion and gene expression by Pearton, Marc, Saller, Verena, Coulman, Sion A., Gateley, Chris, Anstey, Alexander V., Zarnitsyn, Vladimir, Birchall, James C.

“…Microneedle delivery of nucleic acids, in particular plasmid DNA (pDNA), to the skin represents a potential new approach for the clinical management of genetic…”
Get full text

Lifestyle interventions affecting hepatic fatty acid metabolism by Parry, Sion A., Turner, Mark C., Hodson, Leanne

“…PURPOSE OF REVIEWPrevalence of metabolic-associated fatty liver disease (MAFLD) is increasing, and as pharmacological treatment does not exist, lifestyle…”
Get full text

Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes by Arikat, Farah, Hanna, Stephanie J., Singh, Ravinder K., Vilela, Luciano, Wong, F. Susan, Dayan, Colin M., Coulman, Sion A., Birchall, James C.

“…Antigen-specific immunotherapy (ASI) has been proposed as an alternative treatment strategy for type 1 diabetes (T1D). ASI aims to induce a regulatory, rather…”
Get full text

An analysis of the relationship between microneedle spacing, needle force and skin strain during the indentation phase prior to skin penetration by Potts, Matthew R., Evans, Sam L., Pullin, Rhys, Coulman, Sion A., Birchall, James C., Wyatt, Hayley

“…Microneedle (MN) array patches present a promising new approach for the minimally invasive delivery of therapeutics and vaccines. However, ensuring…”
Get full text

Dissociation between liver fat content and fasting metabolic markers of selective hepatic insulin resistance in humans by Westcott, Felix A, Nagarajan, Shilpa R, Parry, Sion A, Savic, Dragana, Green, Charlotte J, Marjot, Thomas, Johnson, Elspeth, Cornfield, Thomas, Mózes, Ferenc E, O'Rourke, Paige, Mendall, Jessica, Dearlove, David, Fielding, Barbara, Smith, Kieran, Tomlinson, Jeremy W, Hodson, Leanne

“…Fasting hyperglycemia and hypertriglyceridemia are characteristic of insulin resistance (IR) and rodent work has suggested this may be due to selective hepatic…”
Get full text

Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product by Dul, Maria, Alali, Mohammed, Ameri, Mahmoud, Burke, Matthew Douglas, Craig, Christine M., Creelman, Benjamin Paul, Dick, Lisa, Donnelly, Ryan F., Eakins, Michael N., Frivold, Collrane, Forster, Angus Harry, Gilbert, Philippe-Alexandre, Henke, Stefan, Henry, Sebastien, Hunt, Desmond, Lewis, Hayley, Maibach, Howard I., Mistilis, Jessica Joyce, Park, Jung-Hwan, Prausnitz, Mark R., Robinson, David Kenneth, Hernandez, Carmen Amelia Rodriguez, Ross, Charles, Shin, Juyeop, Speaker, Tycho Joseph, Taylor, Kevin Michael, Zehrung, Darin, Birchall, James C., Jarrahian, Courtney, Coulman, Sion A.

“…Microneedle Array Patches (MAPs) are an emerging dosage form that creates transient micron-sized disruptions in the outermost physical skin barrier, the…”
Get full text

An anisotropic, hyperelastic model for skin: Experimental measurements, finite element modelling and identification of parameters for human and murine skin by Groves, Rachel B., Coulman, Sion A., Birchall, James C., Evans, Sam L.

“…The mechanical characteristics of skin are extremely complex and have not been satisfactorily simulated by conventional engineering models. The ability to…”
Get full text

Microneedle mediated delivery of nanoparticles into human skin by Coulman, Sion A., Anstey, Alexander, Gateley, Chris, Morrissey, Anthony, McLoughlin, Peter, Allender, Chris, Birchall, James C.

“…The development of novel cutaneous delivery technologies that can produce micron-sized channels within the outermost skin layers has stimulated interest in the…”
Get full text

Skin vaccination using microneedles coated with a plasmid DNA cocktail encoding nucleosomal histones of Leishmania spp by Moreno, Esther, Schwartz, Juana, Calvo, Alba, Blanco, Laura, Larrea, Esther, Irache, Juan M., Sanmartín, Carmen, Coulman, Sion A., Soto, Manuel, Birchall, James C., Espuelas, Socorro

“…[Display omitted] Vaccine delivery using microneedles (MNs) represents a safe, easily disposable and painless alternative to traditional needle immunizations…”
Get full text

Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept by Chong, Rosalind H.E., Gonzalez-Gonzalez, Emilio, Lara, Maria F., Speaker, Tycho J., Contag, Christopher H., Kaspar, Roger L., Coulman, Sion A., Hargest, Rachel, Birchall, James C.

“…The development of siRNA-based gene silencing therapies has significant potential for effectively treating debilitating genetic, hyper-proliferative or…”
Get full text

Fasting hepatic de novo lipogenesis is not reliably assessed using circulating fatty acid markers by Rosqvist, Fredrik, McNeil, Catriona A, Pramfalk, Camilla, Parry, Sion A, Low, Wee Suan, Cornfield, Thomas, Fielding, Barbara A, Hodson, Leanne

“…Observational studies often infer hepatic de novo lipogenesis (DNL) by measuring circulating fatty acid (FA) markers; however, it remains to be elucidated…”
Get full text

Models and methods to characterise levonorgestrel release from intradermally administered contraceptives by Al Dalaty, Adnan, Gualeni, Benedetta, Coulman, Sion A., Birchall, James C.

“…Microneedle (MN)-based technologies have been proposed as a means to facilitate minimally invasive sustained delivery of long-acting hormonal contraceptives…”
Get full text

SLA-Printed 3-D Waveguide Paths for E-Band Using Electroless Silver Plating by Lomakin, Konstantin, Gold, G., Herold, S., Ringel, L., Ringel, J., Simon, D., Sippel, M., Sion, A., Vossiek, M., Helmreich, K.

“…This paper proposes a fabrication approach for 3-D printed waveguide paths based on a combination of an optimized electroless silver plating process with a…”
Get full text

Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides by Singh, Ravinder K., Malosse, Camille, Davies, Joanne, Malissen, Bernard, Kochba, Efrat, Levin, Yotam, Birchall, James C., Coulman, Sion A, Mous, Jan, McAteer, Martina A., Dayan, Colin M., Henri, Sandrine, Wong, F. Susan

“…Ultra-small 1-2 nm gold nanoparticles (NP) were conjugated with a poorly-soluble peptide auto-antigen, associated with type 1 diabetes, to modify the peptide…”
Get full text

The influence of nutritional state on the fatty acid composition of circulating lipid fractions: implications for their use as biomarkers of dietary fat intake by Parry, Sion A, Rosqvist, Fredrik, Peters, Sarah, Young, Rebecca K, Cornfield, Thomas, Dyson, Pamela, Hodson, Leanne

“…The fatty acid (FA) composition of blood can be used as an objective biomarker of dietary FA intake. It remains unclear how the nutritional state influences…”
Get full text

Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes by Zhao, Xin, Birchall, James C., Coulman, Sion A., Tatovic, Danijela, Singh, Ravinder K., Wen, Li, Wong, F. Susan, Dayan, Colin M., Hanna, Stephanie J.

“…Antigen specific immunotherapy mediated via the sustained generation of regulatory T cells arguably represents the ideal therapeutic approach to preventing…”
Get full text