Search Results - "Sinxadi, Phumla"

Pharmacokinetic interactions of modern antiretroviral therapy by Sinxadi, Phumla Z., Khoo, Saye H., Boffito, Marta

“…Drug--drug interactions (DDIs) have been a clinical challenge in HIV medicine for over two decades. The newer antiretroviral drugs (ARTs) have significantly…”
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Pharmacokinetics of Single-Dose Versus Double-Dose Dolutegravir After Switching From a Failing Efavirenz-Based Regimen by Griesel, Rulan, Banda, Clifford G, Zhao, Ying, Omar, Zaayid, Wiesner, Lubbe, Meintjes, Graeme, Sinxadi, Phumla, Maartens, Gary

“…Dolutegravir exposure is reduced after switching from efavirenz, which could select for dolutegravir resistance if switching occurs during virologic failure…”
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Pharmacogenetics of the Late-Onset Efavirenz Neurotoxicity Syndrome (LENS) by van Rensburg, Roland, Nightingale, Sam, Brey, Naeem, Albertyn, Christine H, Kellermann, Tracy A, Taljaard, Jantjie J, Esterhuizen, Tonya M, Sinxadi, Phumla Z, Decloedt, Eric H

“…Abstract Background The late-onset efavirenz neurotoxicity syndrome (LENS) presents as ataxia and/or encephalopathy with supratherapeutic efavirenz plasma…”
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Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites by Decloedt, Eric H, Sinxadi, Phumla Z, van Zyl, Gert U, Wiesner, Lubbe, Khoo, Saye, Joska, John A, Haas, David W, Maartens, Gary

“…Abstract Background There are limited data on the pharmacogenetics and pharmacokinetics of the CNS penetration of efavirenz. Objectives We investigated genetic…”
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Pharmacogenetics of plasma efavirenz exposure in HIV‐infected adults and children in South Africa by Sinxadi, Phumla Z., Leger, Paul D., McIlleron, Helen M., Smith, Peter J., Dave, Joel A., Levitt, Naomi S, Maartens, Gary, Haas, David W.

“…Aims Genetic factors, notably CYP2B6 516G→T [rs3745274] and 983T→C [rs28399499], explain much of the interindividual variability in efavirenz pharmacokinetics,…”
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Genetic Associations with Weight Gain among South Africans who Initiated Dolutegravir-Containing and Tenofovir-Containing Regimens by Cindi, Zinhle, Maartens, Gary, Bradford, Yuki, Venter, Willem D.F., Sokhela, Simiso, Chandiwana, Nomathemba C., Haas, David W., Sinxadi, Phumla

“…Excessive weight gain affects some HIV-positive individuals prescribed dolutegravir-containing regimens. Mechanisms underlying such weight gain are unknown…”
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Simultaneous Determination of Carvedilol, Enalaprilat, and Perindoprilat in Human Plasma Using LC–MS/MS and Its Application to a Pharmacokinetic Pilot Study by Joubert, Andre, Kellermann, Tracy, Joubert, Anton, van der Merwe, Marthinus, Norman, Jennifer, Castel, Sandra, Sliwa, Karen, Maartens, Gary, Sinxadi, Phumla, Wiesner, Lubbe

“…A method for the extraction and quantification of carvedilol, enalaprilat, and perindoprilat in 50 µL human plasma, using high-performance liquid…”
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Weight gain on dolutegravir: Association is not the same as causation by Maartens, Gary, Sinxadi, Phumla, Venter, W.D. Francois

“…Efavirenz concentrations are highly variable, which is mainly due to loss-of-function mutations in genes encoding for the cytochrome P450 enzymes responsible…”
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Population pharmacokinetics of tenofovir given as either tenofovir disoproxil fumarate or tenofovir alafenamide in an African population by Kawuma, Aida N., Wasmann, Roeland E., Sinxadi, Phumla, Sokhela, Simiso M., Chandiwana, Nomathemba, Venter, Willem D. F., Wiesner, Lubbe, Maartens, Gary, Denti, Paolo

“…Tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) are prodrugs of the nucleotide analogue tenofovir, which acts intracellularly to inhibit…”
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Effect of obesity on dolutegravir exposure in Black Southern African adults living with HIV by Mondleki, Enkosi, Banda, Clifford G, Chandiwana, Nomathemba C, Sokhela, Simiso, Wiesner, Lubbe, Venter, Francois, Maartens, Gary, Sinxadi, Phumla Z

“…Dolutegravir, a component of the preferred first-line antiretroviral therapy regimen, has been associated with increased weight gain. South Africa has a high…”
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Effects of rifampin-based antituberculosis therapy on plasma efavirenz concentrations in children vary by CYP2B6 genotype by MCILLERON, Helen M, SCHOMAKER, Michael, HAAS, David W, MAARTENS, Gary, YUAN REN, SINXADI, Phumla, NUTTALL, James J. C, GOUS, Hermien, MOULTRIE, Harry, ELEY, Brian, MERRY, Concepta, SMITH, Peter

“…An efavirenz-based antiretroviral therapy (ART) regimen is preferred for children more than 3 years of age with tuberculosis. However, rifampin, a key…”
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Pharmacogenomics of Hypertension in Africa: Paving the Way for a Pharmacogenetic-Based Approach for the Treatment of Hypertension in Africans by Katsukunya, Jonathan N., Soko, Nyarai D., Naidoo, Jashira, Rayner, Brian, Blom, Dirk, Sinxadi, Phumla, Chimusa, Emile R., Dandara, Michelle, Dzobo, Kevin, Jones, Erika, Dandara, Collet

“…In Africa, the burden of hypertension has been rising at an alarming rate for the last two decades and is a major cause for cardiovascular disease (CVD)…”
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Management of drug-induced liver injury in people with HIV treated for tuberculosis: 2024 update by Boyles, Tom, Berhanu, Rebecca H, Gogela, Neliswa, Gunter, Hannah, Lovelock, Tamsin, Mphothulo, Ndiviwe, Parker, Arifa, Rabie, Helena, Richards, Lauren, Sinxadi, Phumla, Wattrus, Camilla, Moosa, Mahomed-Yunus

“…Background In 2022, South Africa (SA) had one of the highest incidences of TB globally.2 An estimated 60% of new TB cases in SA are in persons with HIV (PWH).3…”
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Pharmacogenetics of tenofovir and emtricitabine penetration into cerebrospinal fluid by Decloedt, Eric H, Sinxadi, Phumla Z, Wiesner, Lubbe, Joska, John A, Haas, David W, Maartens, Gary

“…Blood-cerebrospinal fluid (CSF) barrier transporters affect the influx and efflux of drugs. The antiretrovirals tenofovir and emtricitabine may be substrates…”
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Objectively measured medication adherence using assays for carvedilol and enalaprilat in patients with heart failure in Mozambique and Nigeria by Mwita, Julius Chacha, Joubert, Andre, Saidu, Hadiza, Sani, Mahmoud Umar, Damasceno, Albertino, Mocumbi, Ana Olga, Sinxadi, Phumla, Viljoen, Charle Andre, Hoevelmann, Julian, Gebreyesus, Manna Semere, Denti, Paolo, Wasmann, Roeland, Maartens, Gary, Wiesner, Lubbe, Stewart, Simon, Davison, Beth, Cotter, Gad, Sliwa, Karen

“…Poor medication adherence leads to poor health outcomes and increased healthcare costs among patients with heart failure (HF). This study aimed to objectively…”
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Validation of a quantitative multiplex LC-MS/MS assay of carvedilol, enalaprilat, and perindoprilat in dried blood spots from heart failure patients and its cross validation with a plasma assay by Joubert, Andre, Joubert, Anton, van der Merwe, Marthinus, Norman, Jennifer, Castel, Sandra, Denti, Paolo, Sliwa, Karen, Maartens, Gary, Sinxadi, Phumla, Wiesner, Lubbe

“…•Simultaneous determination of carvedilol, enalaprilat, and perindoprilat in DBS.•Good correlation between DBS and plasma pharmacokinetic samples.•Foundation…”
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Low-dose ritonavir-boosted darunavir once daily versus ritonavir-boosted lopinavir for participants with less than 50 HIV RNA copies per mL (WRHI 052): a randomised, open-label, phase 3, non-inferiority trial by Venter, Willem D F, Moorhouse, Michelle, Sokhela, Simiso, Serenata, Celicia, Akpomiemie, Godspower, Qavi, Ambar, Mashabane, Nonkululeko, Arulappan, Natasha, Sim, Joel W, Sinxadi, Phumla Z, Wiesner, Lubbe, Maharaj, Ellisha, Wallis, Carole, Boyles, Tom, Ripin, David, Stacey, Sarah, Chitauri, Gila, Hill, Andrew

“…Pilot studies suggest that ritonavir-boosted darunavir could show high efficacy at doses below those currently approved. We investigated whether switch to 400…”
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Understanding the Implications of Mitochondrial DNA Variation in the Health of Black Southern African Populations: The 2014 Workshop by van der Westhuizen, Francois H., Sinxadi, Phumla Z., Dandara, Collet, Smuts, Izelle, Riordan, Gillian, Meldau, Surita, Malik, Afshan N., Sweeney, Mary G., Tsai, Yuchia, Towers, Gordon W., Louw, Roan, Gorman, Grainne S., Payne, Brendan A., Soodyall, Himla, Pepper, Michael S., Elson, Joanna L.

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Mitochondrial genomics and antiretroviral therapy-associated metabolic complications in HIV-infected Black South Africans: a pilot study by Sinxadi, Phumla Z, Dave, Joel A, Samuels, David C, Heckmann, Jeannine M, Maartens, Gary, Levitt, Naomi S, Wester, C William, Haas, David W, Hulgan, Todd

“…Studies suggest that mitochondrial DNA (mtDNA) haplogroups are associated with antiretroviral therapy (ART)-related metabolic complications and distal sensory…”
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Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study by Sinxadi, Phumla Z, McIlleron, Helen M, Dave, Joel A, Smith, Peter J, Levitt, Naomi S, Maartens, Gary

“…Dyslipidaemia and dysglycaemia have been associated with exposure to ritonavir-boosted protease inhibitors. Lopinavir/ritonavir, the most commonly used…”
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