Search Results - "Sinton, Christopher M."

Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep by Mieda, Michihiro, Hasegawa, Emi, Kisanuki, Yaz Y, Sinton, Christopher M, Yanagisawa, Masashi, Sakurai, Takeshi

“…Orexin-A and orexin-B are hypothalamic neuropeptides that play critical roles in the maintenance of wakefulness. Intracerebroventricular (ICV) administration…”
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Behavioral and biochemical dissociation of arousal and homeostatic sleep need influenced by prior wakeful experience in mice by Suzuki, Ayako, Sinton, Christopher M., Greene, Robert W., Yanagisawa, Masashi

“…Sleep is regulated by homeostatic mechanisms, and the low-frequency power in the electroencephalogram (delta power) during non-rapid eye movement sleep…”
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Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline by Jessberger, Sebastian, Nakashima, Kinichi, Clemenson, Gregory D., Jr, Mejia, Eunice, Mathews, Emily, Ure, Kerstin, Ogawa, Shiori, Sinton, Christopher M, Gage, Fred H, Hsieh, Jenny

“…The conceptual understanding of hippocampal function has been challenged recently by the finding that new granule cells are born throughout life in the…”
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Orexin/hypocretin plays a role in the response to physiological disequilibrium by Sinton, Christopher M

“…Summary In the decade since the discovery that pathology of the orexin/hypocretin system is causative for the sleep disorder narcolepsy, considerable progress…”
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Orexin Peptides Prevent Cataplexy and Improve Wakefulness in an Orexin Neuron-Ablated Model of Narcolepsy in Mice by Mieda, Michihiro, Willie, Jon T., Hara, Junko, Sinton, Christopher M., Sakurai, Takeshi, Yanagisawa, Masashi

“…Narcolepsy-cataplexy is a neurological disorder associated with the inability to maintain wakefulness and abnormal intrusions of rapid eye movement…”
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Glut1 deficiency (G1D): Epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype by Marin-Valencia, Isaac, Good, Levi B, Ma, Qian, Duarte, Joao, Bottiglieri, Teodoro, Sinton, Christopher M, Heilig, Charles W, Pascual, Juan M

“…Abstract Brain glucose supplies most of the carbon required for acetyl-coenzyme A (acetyl-CoA) generation (an important step for myelin synthesis) and for…”
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To eat or to sleep? Orexin in the regulation of feeding and wakefulness by WILLIE, Jon T, CHEMELLI, Richard M, SINTON, Christopher M, YANAGISAWA, Masashi

“…Orexin-A and orexin-B are neuropeptides originally identified as endogenous ligands for two orphan G-protein-coupled receptors. Orexin neuropeptides (also…”
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Mesolimbic neuropeptide W coordinates stress responses under novel environments by Motoike, Toshiyuki, Long, Jeffrey M., Tanaka, Hirokazu, Sinton, Christopher M., Skach, Amber, Williams, S. Clay, Hammer, Robert E., Sakurai, Takeshi, Yanagisawa, Masashi

“…Neuropeptide B (NPB) and neuropeptide W(NPW) are endogenous neuropeptide ligands for the G protein-coupled receptors NPBWR1 and NPBWR2. Here we report that the…”
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Orexin Neurons Function in an Efferent Pathway of a Food-Entrainable Circadian Oscillator in Eliciting Food-Anticipatory Activity and Wakefulness by Mieda, Michihiro, Williams, S. Clay, Sinton, Christopher M, Richardson, James A, Sakurai, Takeshi, Yanagisawa, Masashi

“…Temporal restriction of feeding can entrain circadian behavioral and physiological rhythms in mammals. Considering the critical functions of the hypothalamic…”
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Expression of a Poly-Glutamine-Ataxin-3 Transgene in Orexin Neurons Induces Narcolepsy-Cataplexy in the Rat by Beuckmann, Carsten T, Sinton, Christopher M, Williams, S. Clay, Richardson, James A, Hammer, Robert E, Sakurai, Takeshi, Yanagisawa, Masashi

“…The sleep disorder narcolepsy has been linked to loss of hypothalamic neurons producing the orexin (hypocretin) neuropeptides. Here, we report the generation…”
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Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep by Funato, Hiromasa, Sato, Makito, Sinton, Christopher M., Gautron, Laurent, Williams, S. Clay, Skach, Amber, Elmquist, Joel K., Skoultchi, Arthur I., Yanagisawa, Masashi

“…Sleep and wakefulness are regulated primarily by inhibitory interactions between the hypothalamus and brainstem. The expression of the states of rapid eye…”
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Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5 by Hawasli, Ammar H, Koovakkattu, Della, Hayashi, Kanehiro, Anderson, Anne E, Powell, Craig M, Sinton, Christopher M, Bibb, James A, Cooper, Donald C

“…Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic plasticity, neurotransmission,…”
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Behavioral phenotyping based on physical inactivity can predict sleep in female rats before, during, and after sleep disruption by Kostiew, Kora N, Tuli, Diya, Coborn, Jamie E, Sinton, Christopher M, Teske, Jennifer A

“…A noninvasive method that can accurately quantify sleep before, during, and after sleep disruption (SD) has not been validated in female rats across their…”
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Pten deletion in adult hippocampal neural stem/progenitor cells causes cellular abnormalities and alters neurogenesis by Amiri, Anahita, Cho, Woosung, Zhou, Jing, Birnbaum, Shari G, Sinton, Christopher M, McKay, Renée M, Parada, Luis F

“…Adult neurogenesis persists throughout life in restricted brain regions in mammals and is affected by various physiological and pathological conditions. The…”
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Neuropeptide B-Deficient Mice Demonstrate Hyperalgesia in Response to Inflammatory Pain by Kelly, Michele A., Beuckmann, Carsten T., Williams, S. Clay, Sinton, Christopher M., Motoike, Toshiyuki, Richardson, James A., Hammer, Robert E., Garry, Mary G., Yanagisawa, Masashi

“…Neuropeptide B (NPB) and neuropeptide W (NPW) have been recently identified as ligands for the G protein-coupled receptor (GPR) 7 and GPR8. The precise in vivo…”
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Sleep loss in male rats contributes more to weight gain during sleep disruption than stress assessed by corticosterone by Houser, Monica M., Coborn, Jamie E., Sinton, Christopher M., Perez-Leighton, Claudio E., Teske, Jennifer A.

“…•Weight gain during sleep disruption induced by noise is not driven by stress as assessed by corticosterone.•Sleep loss due to gentle handling is more…”
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Noise-induced sleep disruption increases weight gain and decreases energy metabolism in female rats by Coborn, Jamie E., Lessie, Rebecca E., Sinton, Christopher M., Rance, Naomi E., Perez-Leighton, Claudio E., Teske, Jennifer A.

“…Background/objectives Inadequate sleep increases obesity and environmental noise contributes to poor sleep. However, women may be more vulnerable to noise and…”
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Promotion of Wakefulness and Energy Expenditure by Orexin-A in the Ventrolateral Preoptic Area by Mavanji, Vijayakumar, Perez-Leighton, Claudio E, Kotz, Catherine M, Billington, Charles J, Parthasarathy, Sairam, Sinton, Christopher M, Teske, Jennifer A

“…The ventrolateral preoptic area (VLPO) and the orexin/hypocretin neuronal system are key regulators of sleep onset, transitions between vigilance states, and…”
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Validation of a novel method to interrupt sleep in the mouse by Sinton, Christopher M., Kovakkattu, Della, Friese, Randall S.

“…Interrupted sleep, fragmented sleep or restricted sleep is a corollary of many psychiatric, neurological and respiratory disorders and also results from…”
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Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity by Hara, Junko, Beuckmann, Carsten T., Nambu, Tadahiro, Willie, Jon T., Chemelli, Richard M., Sinton, Christopher M., Sugiyama, Fumihiro, Yagami, Ken-ichi, Goto, Katsutoshi, Yanagisawa, Masashi, Sakurai, Takeshi

“…Orexins (hypocretins) are a pair of neuropeptides implicated in energy homeostasis and arousal. Recent reports suggest that loss of orexin-containing neurons…”
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