Search Results - "Sinsheimer, J S"

Bayesian selection of continuous-time Markov chain evolutionary models by Suchard, M A, Weiss, R E, Sinsheimer, J S

“…We develop a reversible jump Markov chain Monte Carlo approach to estimating the posterior distribution of phylogenies based on aligned DNA/RNA sequences under…”
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Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus by Snelling, S., Sinsheimer, J. S., Carr, A., Loughlin, J.

“…Objective. A genetic association with knee osteoarthritis (OA) of a single nucleotide polymorphism (SNP) in intron 1 of the LRCH1 gene was recently reported in…”
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The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population by Loughlin, J., Sinsheimer, J.S., Carr, A., Chapman, K.

“…A convincing genetic association with hip osteoarthritis (OA) of a functional single nucleotide polymorphism (SNP) in the core promoter of the calmodulin 1…”
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Linkage analysis of candidate genes as susceptibility loci for osteoarthritis—suggestive linkage of COL9A1 to female hip osteoarthritis by Mustafa, Z., Chapman, K., Irven, C., Carr, A. J., Clipsham, K., Chitnavis, J., Sinsheimer, J. S., Bloomfield, V. A., McCartney, M., Cox, O., Sykes, B., Loughlin, J.

“…Objective. To examine 11 candidate genes as susceptibility loci for osteoarthritis (OA). Methods. A total of 481 families have been ascertained in which at…”
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End‐stage coxarthrosis and gonarthrosis. Aetiology, clinical patterns and radiological features of idiopathic osteoarthritis by Chitnavis, J., Sinsheimer, J. S., Suchard, M. A., Clipsham, K., Carr, A. J.

“…Objectives. To determine and compare the aetiological background, clinical patterns and radiological features of idiopathic osteoarthritis (OA) of the hip and…”
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Osteoarthritis-Susceptibility Locus on Chromosome 11q, Detected by Linkage by Chapman, Kay, Mustafa, Zehra, Irven, Catherine, Carr, Andrew J., Clipsham, Kim, Smith, Anne, Chitnavis, Jai, Sinsheimer, Janet S., Bloomfield, Victoria A., McCartney, Mary, Cox, Olive, Cardon, Lon R., Sykes, Bryan, Loughlin, John

“…We present a two-stage genomewide scan for osteoarthritis-susceptibility loci, using 481 families that each contain at least one affected sibling pair. The…”
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Association analysis of the vitamin D receptor gene, the type I collagen gene COL1A1, and the estrogen receptor gene in idiopathic osteoarthritis by Loughlin, J, Sinsheimer, J S, Mustafa, Z, Carr, A J, Clipsham, K, Bloomfield, V A, Chitnavis, J, Bailey, A, Sykes, B, Chapman, K

“…Evidence has accumulated supporting a role for genes in the etiology of osteoarthritis (OA). Several candidates have been targeted as potential susceptibility…”
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Gamete-Competition Models by Sinsheimer, Janet S., Blangero, John, Lange, Kenneth

“…The gamete-competition model is an application of the Bradley-Terry model for ranking of sports teams. If allele i of a marker locus is assigned parameter τ…”
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Head injury, α-synuclein genetic variability and Parkinson's disease by Lee, P. C., Bordelon, Y., Bronstein, J., Sinsheimer, J. S., Farrer, M., Ritz, B.

“…Background and purpose Head injury has been linked to Parkinson's disease (PD) in some but not all studies. Differences in the genetic and environmental…”
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Fishing for Pleiotropic QTLs in a Polygenic Sea by Bauman, L. E., Almasy, L., Blangero, J., Duggirala, R., Sinsheimer, J. S., Lange, K.

“…Summary The application of factor analysis to human genetics has the potential to discover the coordinated control of multiple traits by common environment,…”
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In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects by Lech, W J, Wang, G, Yang, Y L, Chee, Y, Dorman, K, McCrae, D, Lazzeroni, L C, Erickson, J W, Sinsheimer, J S, Kaplan, A H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Linkage analysis of chromosome 2q in osteoarthritis by Loughlin, J., Mustafa, Z., Smith, A., Irven, C., Carr, A. J., Clipsham, K., Chitnavis, J., Bloomfield, V. A., McCartney, M., Cox, O., Sinsheimer, J. S., Sykes, B., Chapman, K. E.

“…Background In independent linkage studies chromosome 2q11‐q24 and chromosome 2q23–35 have previously been implicated as regions potentially harbouring…”
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Penalized regression for genome-wide association screening of sequence data by Zhou, H, Alexander, D H, Sehl, M E, Sinsheimer, J S, Sobel, E M, Lange, K

“…Whole exome and whole genome sequencing are likely to be potent tools in the study of common diseases and complex traits. Despite this promise, some very…”
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Familial combined hyperlipidemia is associated with upstream transcription factor 1 ( USF1 ) by Pajukanta, Päivi, Peltonen, Leena, Lilja, Heidi E, Sinsheimer, Janet S, Cantor, Rita M, Lusis, Aldons J, Gentile, Massimiliano, Duan, Xiaoqun Joyce, Soro-Paavonen, Aino, Naukkarinen, Jussi, Saarela, Janna, Laakso, Markku, Ehnholm, Christian, Taskinen, Marja-Riitta

“…Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total cholesterol, triglycerides or both, is observed in about 20% of…”
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No evidence of linkage or linkage disequilibrium between DAT1 and attention deficit hyperactivity disorder in a large sample by Palmer, C G, Bailey, J N, Ramsey, C, Cantwell, D, Sinsheimer, J S, Del'Homme, M, McGough, J, Woodward, J A, Asarnow, R, Asarnow, J, Nelson, S, Smalley, S L

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SNPs and snails and puppy dogs' tails: analysis of SNP haplotype data using the gamete competition model by SINSHEIMER, J. S., MCKENZIE, C. A., KEAVNEY, B., LANGE, K.

“…The gamete competition model is a likelihood version of the transmission disequilibrium test (TDT) that is inspired by conditional logistic regression and the…”
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A Genomewide Screen for Autism-Spectrum Disorders: Evidence for a Major Susceptibility Locus on Chromosome 3q25-27 by Auranen, Mari, Vanhala, Raija, Varilo, Teppo, Ayers, Kristin, Kempas, Elli, Ylisaukko-oja, Tero, Sinsheimer, Janet S., Peltonen, Leena, Järvelä, Irma

“…To identify genetic loci for autism-spectrum disorders, we have performed a two-stage genomewide scan in 38 Finnish families. The detailed clinical examination…”
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Dissecting prenatal, postnatal, and inherited effects: ART and design by Zhou, J.J., Pelka, S., Lange, K., Palmer, C.G.S., Sinsheimer, J.S.

“…With the failure of common variants alone to explain the bulk of trait heritability, it becomes more important to understand the contribution of maternally…”
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Chromosome 1 loci in finnish schizophrenia families by EKELUND, Jesper, HOVATTA, Iiris, SOBEL, Eric, JUVONEN, Hannu, ARAJÄRVI, Ritva, PARTONEN, Timo, SUVISAARI, Jaana, LÖNNQVIST, Jouko, MEYER, Joanne, PELTONEN, Leena, PARKER, Alex, PAUNIO, Tiina, VARILO, Teppo, MARTIN, Rory, SUHONEN, Johanna, ELLONEN, Pekka, GAYUN CHAN, SINSHEIMER, Janet S

“…We have earlier reported evidence for linkage to two regions on chromosome 1q32--q42 in schizophrenia families collected for two separate studies in Finland…”
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Hierarchical Phylogenetic Models for Analyzing Multipartite Sequence Data by Suchard, Marc A., Kitchen, Christina M. R., Sinsheimer, Janet S., Weiss, Robert E., Yang, Ziheng

“…Debate exists over how to incorporate information from multipartite sequence data in phylogenetic analyses. Strict combined-data approaches argue for…”
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