Search Results - "Sinnreich, Michael"

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia by Ham, Daniel J., Börsch, Anastasiya, Lin, Shuo, Thürkauf, Marco, Weihrauch, Martin, Reinhard, Judith R., Delezie, Julien, Battilana, Fabienne, Wang, Xueyong, Kaiser, Marco S., Guridi, Maitea, Sinnreich, Michael, Rich, Mark M., Mittal, Nitish, Tintignac, Lionel A., Handschin, Christoph, Zavolan, Mihaela, Rüegg, Markus A.

“…With human median lifespan extending into the 80s in many developed countries, the societal burden of age-related muscle loss (sarcopenia) is increasing…”
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Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy by Castets, Perrine, Lin, Shuo, Rion, Nathalie, Di Fulvio, Sabrina, Romanino, Klaas, Guridi, Maitea, Frank, Stephan, Tintignac, Lionel A., Sinnreich, Michael, Rüegg, Markus A.

“…Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3…”
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Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice by Ozcelik, Sefika, Fraser, Graham, Castets, Perrine, Schaeffer, Véronique, Skachokova, Zhiva, Breu, Karin, Clavaguera, Florence, Sinnreich, Michael, Kappos, Ludwig, Goedert, Michel, Tolnay, Markus, Winkler, David Theo

“…Altered autophagy contributes to the pathogenesis of Alzheimer's disease and other tauopathies, for which curative treatment options are still lacking. We have…”
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mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4 by Castets, Perrine, Rion, Nathalie, Théodore, Marine, Falcetta, Denis, Lin, Shuo, Reischl, Markus, Wild, Franziska, Guérard, Laurent, Eickhorst, Christopher, Brockhoff, Marielle, Guridi, Maitea, Ibebunjo, Chikwendu, Cruz, Joseph, Sinnreich, Michael, Rudolf, Rüdiger, Glass, David J., Rüegg, Markus A.

“…Loss of innervation of skeletal muscle is a determinant event in several muscle diseases. Although several effectors have been identified, the pathways…”
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Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle by Ham, Daniel J., Börsch, Anastasiya, Chojnowska, Kathrin, Lin, Shuo, Leuchtmann, Aurel B., Ham, Alexander S., Thürkauf, Marco, Delezie, Julien, Furrer, Regula, Burri, Dominik, Sinnreich, Michael, Handschin, Christoph, Tintignac, Lionel A., Zavolan, Mihaela, Mittal, Nitish, Rüegg, Markus A.

“…Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie restriction (CR) potently extends health and lifespan, but is…”
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Nerve ultrasound for differentiation between amyotrophic lateral sclerosis and multifocal motor neuropathy by Grimm, Alexander, Décard, Bernhard F., Athanasopoulou, Ioanna, Schweikert, Kathi, Sinnreich, Michael, Axer, Hubertus

“…Ultrasound is useful for non-invasive visualization of focal nerve pathologies probably resulting from demyelination, remyelination, edema or inflammation. In…”
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Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I by Brockhoff, Marielle, Rion, Nathalie, Chojnowska, Kathrin, Wiktorowicz, Tatiana, Eickhorst, Christopher, Erne, Beat, Frank, Stephan, Angelini, Corrado, Furling, Denis, Rüegg, Markus A, Sinnreich, Michael, Castets, Perrine

“…Myotonic dystrophy type I (DM1) is a disabling multisystemic disease that predominantly affects skeletal muscle. It is caused by expanded CTG repeats in the…”
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Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study by Hafner, Patricia, Bonati, Ulrike, Erne, Beat, Schmid, Maurice, Rubino, Daniela, Pohlman, Urs, Peters, Thomas, Rutz, Erich, Frank, Stephan, Neuhaus, Cornelia, Deuster, Stefanie, Gloor, Monika, Bieri, Oliver, Fischmann, Arne, Sinnreich, Michael, Gueven, Nuri, Fischer, Dirk

“…Altered neuronal nitric oxide synthase function in Duchenne muscular dystrophy leads to impaired mitochondrial function which is thought to be one cause of…”
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Author Correction: Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle by Ham, Daniel J., Börsch, Anastasiya, Chojnowska, Kathrin, Lin, Shuo, Leuchtmann, Aurel B., Ham, Alexander S., Thürkauf, Marco, Delezie, Julien, Furrer, Regula, Burri, Dominik, Sinnreich, Michael, Handschin, Christoph, Tintignac, Lionel A., Zavolan, Mihaela, Mittal, Nitish, Rüegg, Markus A.

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AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions by Bouquier, Nathalie, Moutin, Enora, Tintignac, Lionel A, Reverbel, Amandine, Jublanc, Elodie, Sinnreich, Michael, Chastagnier, Yan, Averous, Julien, Fafournoux, Pierre, Verpelli, Chiara, Boeckers, Tobias, Carnac, Gilles, Perroy, Julie, Ollendorff, Vincent

“…Abstract Background mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET…”
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Diagnosis of adult-onset MELAS syndrome in a 63-year-old patient with suspected recurrent strokes - a case report by Sinnecker, Tim, Andelova, Michaela, Mayr, Michael, Rüegg, Stephan, Sinnreich, Michael, Hench, Juergen, Frank, Stephan, Schaller, André, Stippich, Christoph, Wuerfel, Jens, Bonati, Leo H

“…Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is a mitochondrial cytopathy caused by mutations in mitochondrial DNA…”
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CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I by Falcetta, Denis, Quirim, Sandrine, Cocchiararo, Ilaria, Chabry, Florent, Théodore, Marine, Stiefvater, Adeline, Lin, Shuo, Tintignac, Lionel, Ivanek, Robert, Kinter, Jochen, Rüegg, Markus A, Sinnreich, Michael, Castets, Perrine

“…Myotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that neuromuscular junctions (NMJs)…”
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mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice by Ham, Alexander S., Chojnowska, Kathrin, Tintignac, Lionel A., Lin, Shuo, Schmidt, Alexander, Ham, Daniel J., Sinnreich, Michael, Rüegg, Markus A.

“…Background The balance between protein synthesis and degradation (proteostasis) is a determining factor for muscle size and function. Signalling via the…”
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Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation by Di Fulvio, Sabrina, Azakir, Bilal A, Therrien, Christian, Sinnreich, Michael

“…Dysferlin is a multi-C2 domain transmembrane protein involved in a plethora of cellular functions, most notably in skeletal muscle membrane repair, but also in…”
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Dysferlin interacts with tubulin and microtubules in mouse skeletal muscle by Azakir, Bilal A, Di Fulvio, Sabrina, Therrien, Christian, Sinnreich, Michael

“…Dysferlin is a type II transmembrane protein implicated in surface membrane repair in muscle. Mutations in dysferlin lead to limb girdle muscular dystrophy 2B,…”
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Calorie restriction and rapamycin distinctly restore non-canonical ORF translation in the muscles of aging mice by Mittal, Nitish, Ataman, Meric, Tintignac, Lionel, Ham, Daniel J., Jörin, Lena, Schmidt, Alexander, Sinnreich, Michael, Ruegg, Markus A., Zavolan, Mihaela

“…Loss of protein homeostasis is one of the hallmarks of aging. As such, interventions that restore proteostasis should slow down the aging process and improve…”
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Protein delivery in intermittent and continuous enteral nutrition with a protein-rich formula in critically ill patients-a protocol for the prospective randomized controlled proof-of-concept Protein Bolus Nutrition (Pro BoNo) study by Reinhold, Simona, Yeginsoy, Desirée, Hollinger, Alexa, Todorov, Atanas, Tintignac, Lionel, Sinnreich, Michael, Kiss, Caroline, Gebhard, Caroline E, Kovács, Balázs, Gysi, Bianca, Imwinkelried, Lara, Siegemund, Martin

“…Critically ill patients rapidly develop muscle wasting resulting in sarcopenia, long-term disability and higher mortality. Bolus nutrition (30-60 min period),…”
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"Get the Balance Right": Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders by Castets, Perrine, Frank, Stephan, Sinnreich, Michael, Rüegg, Markus A

“…Recent research has revealed that autophagy, a major catabolic process in cells, is dysregulated in several neuromuscular diseases and contributes to the…”
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Molecular targets to treat muscular dystrophies by Kinter, Jochen, Sinnreich, Michael

“…Muscular dystrophies are classically subdivided according to their clinical phenotype, and were historically defined as progressive myopathies in which muscle…”
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Mutation impact on dysferlin inferred from database analysis and computer-based structural predictions by Therrien, Christian, Dodig, Dubravka, Karpati, George, Sinnreich, Michael

“…Dysferlin is a large sarcolemmal protein implicated in the repair of surface membrane tears in muscle cells. Mutations in dysferlin result in limb girdle…”
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