Search Results - "Sinnar, Shamim"

The Problem of Microbial Dark Matter in Neonatal Sepsis by Sinnar, Shamim A, Schiff, Steven J

“…Neonatal sepsis (NS) kills 750,000 infants every year. Effectively treating NS requires timely diagnosis and antimicrobial therapy matched to the causative…”
Get full text

Capping protein is essential for cell migration in vivo and for filopodial morphology and dynamics by Sinnar, Shamim A, Antoku, Susumu, Saffin, Jean-Michel, Cooper, Jon A, Halpain, Shelley

“…Capping protein (CP) binds to barbed ends of growing actin filaments and inhibits elongation. CP is essential for actin-based motility in cell-free systems and…”
Get full text

Pan-African evolution of within- and between-country COVID-19 dynamics by Ssentongo, Paddy, Fronterre, Claudio, Geronimo, Andrew, Greybush, Steven J., Mbabazi, Pamela K., Muvawala, Joseph, Nahalamba, Sarah B., Omadi, Philip O., Opar, Bernard T., Sinnar, Shamim A., Wang, Yan, Whalen, Andrew J., Held, Leonhard, Jewell, Christopher, Muwanguzi, Abraham J. B., Greatrex, Helen, Norton, Michael M., Diggle, Peter J., Schiff, Steven J.

“…The coronavirus disease 2019 (COVID-19) pandemic is heterogeneous throughout Africa and threatening millions of lives. Surveillance and short-term modeling…”
Get full text

Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants by Paulson, Joseph N, Williams, Brent L, Hehnly, Christine, Mishra, Nischay, Sinnar, Shamim A, Zhang, Lijun, Ssentongo, Paddy, Mbabazi-Kabachelor, Edith, Wijetunge, Dona S S, von Bredow, Benjamin, Mulondo, Ronnie, Kiwanuka, Julius, Bajunirwe, Francis, Bazira, Joel, Bebell, Lisa M, Burgoine, Kathy, Couto-Rodriguez, Mara, Ericson, Jessica E, Erickson, Tim, Ferrari, Matthew, Gladstone, Melissa, Guo, Cheng, Haran, Murali, Hornig, Mady, Isaacs, Albert M, Kaaya, Brian Nsubuga, Kangere, Sheila M, Kulkarni, Abhaya V, Kumbakumba, Elias, Li, Xiaoxiao, Limbrick, Jr, David D, Magombe, Joshua, Morton, Sarah U, Mugamba, John, Ng, James, Olupot-Olupot, Peter, Onen, Justin, Peterson, Mallory R, Roy, Farrah, Sheldon, Kathryn, Townsend, Reid, Weeks, Andrew D, Whalen, Andrew J, Quackenbush, John, Ssenyonga, Peter, Galperin, Michael Y, Almeida, Mathieu, Atkins, Hannah, Warf, Benjamin C, Lipkin, W Ian, Broach, James R, Schiff, Steven J

“…Postinfectious hydrocephalus (PIH), which often follows neonatal sepsis, is the most common cause of pediatric hydrocephalus worldwide, yet the microbial…”
Get more information

Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus by Hehnly, Christine, Ssentongo, Paddy, Bebell, Lisa M., Burgoine, Kathy, Bazira, Joel, Fronterre, Claudio, Kumbakumba, Elias, Mulondo, Ronald, Mbabazi-Kabachelor, Edith, Morton, Sarah U., Ngonzi, Joseph, Ochora, Moses, Olupot-Olupot, Peter, Mugamba, John, Onen, Justin, Roberts, Drucilla J., Sheldon, Kathryn, Sinnar, Shamim A., Smith, Jasmine, Ssenyonga, Peter, Kiwanuka, Julius, Paulson, Joseph N., Meier, Frederick A., Ericson, Jessica E., Broach, James R., Schiff, Steven J.

“…To estimate the prevalence of cytomegalovirus (CMV) infections among newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus in Uganda…”
Get full text

The Mouse Polyubiquitin Gene Ubb Is Essential for Meiotic Progression by Ryu, Kwon-Yul, Sinnar, Shamim A., Reinholdt, Laura G., Vaccari, Sergio, Hall, Susan, Garcia, Manuel A., Zaitseva, Tatiana S., Bouley, Donna M., Boekelheide, Kim, Handel, Mary Ann, Conti, Marco, Kopito, Ron R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Immune activation during Paenibacillus brain infection in African infants with frequent cytomegalovirus co-infection by Isaacs, Albert M., Morton, Sarah U., Movassagh, Mercedeh, Zhang, Qiang, Hehnly, Christine, Zhang, Lijun, Morales, Diego M., Sinnar, Shamim A., Ericson, Jessica E., Mbabazi-Kabachelor, Edith, Ssenyonga, Peter, Onen, Justin, Mulondo, Ronnie, Hornig, Mady, Warf, Benjamin C., Broach, James R., Townsend, R. Reid, Limbrick, David D., Paulson, Joseph N., Schiff, Steven J.

“…Inflammation during neonatal brain infections leads to significant secondary sequelae such as hydrocephalus, which often follows neonatal sepsis in the…”
Get full text

Vaginal microbiome topic modeling of laboring Ugandan women with and without fever by Movassagh, Mercedeh, Bebell, Lisa M., Burgoine, Kathy, Hehnly, Christine, Zhang, Lijun, Moran, Kim, Sheldon, Kathryn, Sinnar, Shamim A., Mbabazi-Kabachelor, Edith, Kumbakumba, Elias, Bazira, Joel, Ochora, Moses, Mulondo, Ronnie, Nsubuga, Brian Kaaya, Weeks, Andrew D., Gladstone, Melissa, Olupot-Olupot, Peter, Ngonzi, Joseph, Roberts, Drucilla J., Meier, Frederick A., Irizarry, Rafael A., Broach, James R., Schiff, Steven J., Paulson, Joseph N.

“…The composition of the maternal vaginal microbiome influences the duration of pregnancy, onset of labor, and even neonatal outcomes. Maternal microbiome…”
Get full text

Altered testicular gene expression patterns in mice lacking the polyubiquitin gene Ubb by Sinnar, Shamim A., Small, Christopher L., Evanoff, Ryan M., Reinholdt, Laura G., Griswold, Michael D., Kopito, Ron R., Ryu, Kwon-Yul

“…Ubiquitin (Ub) is an essential protein found in all eukaryotic cells and plays important roles in a variety of cellular functions including germ cell…”
Get full text

Diazepam Promotes ATP Recovery and Prevents Cytochrome c Release in Hippocampal Slices After In Vitro Ischemia by Galeffi, Francesca, Sinnar, Shamim, Schwartz‐Bloom, Rochelle D.

“…: Benzodiazepines protect hippocampal neurons when administered within the first few hours after transient cerebral ischemia. Here, we examined the ability of…”
Get full text

2537. Population Pharmacokinetics of Isavuconazole in Pediatric Patients by Desai, Amit, Parasrampuria, Dolly A, Kovanda, Laura, Sinnar, Shamim, Tannenbaum, Stacey

“…Abstract Background Isavuconazole (ISAV) is approved for the treatment of invasive aspergillosis (IA) and invasive mucormycosis (IM) in adults; however, there…”
Get full text

2535. Physiological-based pharmacokinetic analysis of drug–drug interactions between isavuconazole and vincristine in pediatric subjects by Choules, Mary P, Otsuka, Yukio, Kovanda, Laura, Bonate, Peter, Sinnar, Shamim, Desai, Amit

“…Abstract Background Invasive fungal diseases (IFD), including invasive aspergillosis (IA) and invasive mucormycosis (IM), occur primarily in immunocompromised…”
Get full text

1699. Safety and Outcomes of Isavuconazonium Sulfate for the Treatment of Invasive Aspergillosis or Invasive Mucormycosis in Pediatric Patients by Arrieta, Antonio C, Segers, Heidi, Deville, Jaime G, Muller, William J, Manzanares, Angela, Neely, Michael N, Bordon, Victoria, Hanisch, Benjamin, Lassaletta, Alvaro, Fisher, Brian T, Autmizguine, Julie, Groll, Andreas H, Sinnar, Shamim, Croos-Dabrera, Rodney, Engelhardt, Marc, Jones, Mark E, Kovanda, Laura

“…Abstract Background Invasive aspergillosis (IA) and invasive mucormycosis (IM) are life-threatening invasive fungal diseases (IFDs) that occur in critically…”
Get full text

The Role of Capping Protein in Migrating Cells and Neurons by Sinnar, Shamim A

“…Actin capping protein (CP) binds to the barbed ends of actin filaments and inhibits further polymerization. CP is thought to be essential for cell motility,…”
Get full text

Prospective randomized comparison of 1-day and 3-day application of topical 0.5% moxifloxacin in eliminating preoperative conjunctival bacteria by He, Lingmin, Ta, Christopher N, Hu, Nan, Sinnar, Shamim, Miño de Kaspar, Herminia

“…Compare the efficacy of a 1-day versus 3-day application of topical 0.5% moxifloxacin in reducing preoperative conjunctival bacteria. Following IRB approval,…”
Get more information

The Role of Capping Protein in Migrating Cells and Neurons by Sinnar, Shamim A

“…Actin capping protein (CP) binds to the barbed ends of actin filaments and inhibits further polymerization. CP is thought to be essential for cell motility,…”
Get full text