Search Results - "Sinnamon, Robert H."

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction by Gilmartin, Aidan G, Faitg, Thomas H, Richter, Mark, Groy, Arthur, Seefeld, Mark A, Darcy, Michael G, Peng, Xin, Federowicz, Kelly, Yang, Jingsong, Zhang, Shu-Yun, Minthorn, Elisabeth, Jaworski, Jon-Paul, Schaber, Michael, Martens, Stan, McNulty, Dean E, Sinnamon, Robert H, Zhang, Hong, Kirkpatrick, Robert B, Nevins, Neysa, Cui, Guanglei, Pietrak, Beth, Diaz, Elsie, Jones, Amber, Brandt, Martin, Schwartz, Benjamin, Heerding, Dirk A, Kumar, Rakesh

“…Allosteric small-molecule inhibitors of the p53-induced oncogenic phosphatase Wip1 bind at a ‘flap’ subdomain near the catalytic site. Inhibitor GSK2830371…”
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Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions by King, Alastair J, Arnone, Marc R, Bleam, Maureen R, Moss, Katherine G, Yang, Jingsong, Fedorowicz, Kelly E, Smitheman, Kimberly N, Erhardt, Joseph A, Hughes-Earle, Angela, Kane-Carson, Laurie S, Sinnamon, Robert H, Qi, Hongwei, Rheault, Tara R, Uehling, David E, Laquerre, Sylvie G

“…Mitogen-Activated Protein Kinase (MAPK) pathway activation has been implicated in many types of human cancer. BRAF mutations that constitutively activate MAPK…”
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Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase by Concha, Nestor, Huang, Jianzhong, Bai, Xiaopeng, Benowitz, Andrew, Brady, Pat, Grady, LaShadric C, Kryn, Luz Helena, Holmes, David, Ingraham, Karen, Jin, Qi, Pothier Kaushansky, Laura, McCloskey, Lynn, Messer, Jeffrey A, O’Keefe, Heather, Patel, Amish, Satz, Alexander L, Sinnamon, Robert H, Schneck, Jessica, Skinner, Steve R, Summerfield, Jennifer, Taylor, Amy, Taylor, J. David, Evindar, Ghotas, Stavenger, Robert A

“…Undecaprenyl pyrophosphate synthase (UppS) is an essential enzyme in bacterial cell wall synthesis. Here we report the discovery of Staphylococcus aureus UppS…”
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C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site by Ma, Jianhong, Martin, John D., Xue, Yu, Lor, Leng A., Kennedy-Wilson, Karen M., Sinnamon, Robert H., Ho, Thau F., Zhang, Guofeng, Schwartz, Benjamin, Tummino, Peter J., Lai, Zhihong

“…► Deletion of the N-terminal TRAF-like domain of USP7 has no effect on USP7 mediated deubiquitination of Ub n-mdm2 and Ub n-p53. ► Amino acids 208–1102 were…”
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A Biochemical Rationale for the Anticancer Effects of Hsp90 Inhibitors: Slow, Tight Binding Inhibition by Geldanamycin and Its Analogues by Gooljarsingh, Lata T., Fernandes, Christine, Yan, Kang, Zhang, Hong, Grooms, Michael, Johanson, Kyung, Sinnamon, Robert H., Kirkpatrick, Robert B., Kerrigan, John, Lewis, Tia, Arnone, Marc, King, Alastair J., Lai, Zhihong, Copeland, Robert A., Tummino, Peter J.

“…Heat shock protein (Hsp)90 is emerging as an important therapeutic target for the treatment of cancer. Two analogues of the Hsp90 inhibitor geldanamycin are…”
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Cocktailed fragment screening by X‐ray crystallography of the antibacterial target undecaprenyl pyrophosphate synthase from Acinetobacter baumannii by Thorpe, James H., Wall, Ian D., Sinnamon, Robert H., Taylor, Amy N., Stavenger, Robert A.

“…Direct soaking of protein crystals with small‐molecule fragments grouped into complementary clusters is a useful technique when assessing the potential of a…”
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Characterization of PI3K class IA isoforms with regulatory subunit p55α using a scintillation proximity assay by Aller, Glenn S. Van, Carson, Jeff D., Fernandes, Christine, Lehr, Ruth, Sinnamon, Robert H., Kirkpatrick, Robert B., Tummino, Peter J., Luo, Lusong

“…Differential activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway has been linked to cancer. Activation occurs through gene amplification and…”
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Baculovirus production of fully-active phosphoinositide 3-kinase alpha as a p85α–p110α fusion for X-ray crystallographic analysis with ATP competitive enzyme inhibitors by Sinnamon, Robert H., McDevitt, Patrick, Pietrak, Beth L., Leydon, Vaughan R., Xue, Yu, Lehr, Ruth, Qi, Hongwei, Burns, Matthew, Elkins, Patricia, Ward, Paris, Vincentini, Giorgia, Fisher, Donald, Grimes, Maggie, Brandt, Martin, Auger, Kurt R., Ho, Thau, Johanson, Kyung, Jones, Christopher S., Schwartz, Benjamin, Sweitzer, Thomas D., Kirkpatrick, Robert B.

“…Phosphoinositide 3-kinases have been targeted for therapeutic research because they are key components of a cell signaling cascade controlling proliferation,…”
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Characterization of PI3K class IA isoforms with regulatory subunit p55alpha using a scintillation proximity assay by Van Aller, Glenn S, Carson, Jeff D, Fernandes, Christine, Lehr, Ruth, Sinnamon, Robert H, Kirkpatrick, Robert B, Tummino, Peter J, Luo, Lusong

“…Differential activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway has been linked to cancer. Activation occurs through gene amplification and…”
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Baculovirus production of fully-active phosphoinositide 3-kinase alpha as a p85alpha-p110alpha fusion for X-ray crystallographic analysis with ATP competitive enzyme inhibitors by Sinnamon, Robert H, McDevitt, Patrick, Pietrak, Beth L, Leydon, Vaughan R, Xue, Yu, Lehr, Ruth, Qi, Hongwei, Burns, Matthew, Elkins, Patricia, Ward, Paris, Vincentini, Giorgia, Fisher, Donald, Grimes, Maggie, Brandt, Martin, Auger, Kurt R, Ho, Thau, Johanson, Kyung, Jones, Christopher S, Schwartz, Benjamin, Sweitzer, Thomas D, Kirkpatrick, Robert B

“…Phosphoinositide 3-kinases have been targeted for therapeutic research because they are key components of a cell signaling cascade controlling proliferation,…”
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Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase by Carson, Jeffrey D, Van Aller, Glenn, Lehr, Ruth, Sinnamon, Robert H, Kirkpatrick, Robert B, Auger, Kurt R, Dhanak, Dashyant, Copeland, Robert A, Gontarek, Richard R, Tummino, Peter J, Luo, Lusong

“…The PIK3CA gene, encoding the p110alpha catalytic subunit of Class IA PI3Ks (phosphoinositide 3-kinases), is frequently mutated in many human tumours. The…”
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