Search Results - "Sinnamon, John R."

Highly scalable generation of DNA methylation profiles in single cells by Mulqueen, Ryan M, Pokholok, Dmitry, Norberg, Steven J, Torkenczy, Kristof A, Fields, Andrew J, Sun, Duanchen, Sinnamon, John R, Shendure, Jay, Trapnell, Cole, O'Roak, Brian J, Xia, Zheng, Steemers, Frank J, Adey, Andrew C

“…Methylation profiling of single cells in high throughput achieves read-alignment rates approaching bulk cell population studies. We present a highly scalable…”
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Site-directed RNA repair of endogenous Mecp2 RNA in neurons by Sinnamon, John R., Kim, Susan Y., Corson, Glen M., Song, Zhen, Nakai, Hiroyuki, Adelman, John P., Mandel, Gail

“…Rett syndrome (RTT) is a debilitating neurological disorder caused by mutations in the gene encoding the transcription factor Methyl CpG Binding Protein 2…”
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In Vivo Repair of a Protein Underlying a Neurological Disorder by Programmable RNA Editing by Sinnamon, John R., Kim, Susan Y., Fisk, Jenna R., Song, Zhen, Nakai, Hiroyuki, Jeng, Sophia, McWeeney, Shannon K., Mandel, Gail

“…Programmable RNA editing is gaining momentum as an approach to repair mutations, but its efficiency in repairing endogenous mutant RNA in complex tissue is…”
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The accessible chromatin landscape of the murine hippocampus at single-cell resolution by Sinnamon, John R, Torkenczy, Kristof A, Linhoff, Michael W, Vitak, Sarah A, Mulqueen, Ryan M, Pliner, Hannah A, Trapnell, Cole, Steemers, Frank J, Mandel, Gail, Adey, Andrew C

“…Here we present a comprehensive map of the accessible chromatin landscape of the mouse hippocampus at single-cell resolution. Substantial advances of this work…”
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Hnrpab regulates neural development and neuron cell survival after glutamate stimulation by Sinnamon, John R, Waddell, Catherine B, Nik, Sara, Chen, Emily I, Czaplinski, Kevin

“…The molecular mechanisms that govern the timing and fate of neural stem-cell differentiation toward the distinct neural lineages of the nervous system are not…”
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mRNA trafficking and local translation： the Yin and Yang of regulating mRNA localization in neurons by Sinnamon, John R, Czaplinski, Kevin

“…Localized translation and the requisite trafficking of the mRNA template play significant roles in the nervous system including the establishment of dendrites…”
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RNA detection in situ with FISH-STICs by Sinnamon, John R, Czaplinski, Kevin

“…The ability to detect RNA molecules in situ has long had important applications for molecular biological studies. Enzyme or dye-labeled antisense in vitro…”
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Targeted RNA editing in brainstem alleviates respiratory dysfunction in a mouse model of Rett syndrome by Sinnamon, John R, Jacobson, Michael E, Yung, John F, Fisk, Jenna R, Jeng, Sophia, McWeeney, Shannon K, Parmelee, Lindsay K, Chan, Chi Ngai, Yee, Siu-Pok, Mandel, Gail

“…Rett syndrome is a neurological disease due to loss-of-function mutations in the transcription factor, Methyl CpG binding protein 2 (MECP2). Because…”
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Locating RNAs in situ with FISH-STIC probes by Sinnamon, John R, Czaplinski, Kevin

“…The location of a molecule within the cell often provides important clues to its function and regulation, therefore techniques to locate RNA within cells are…”
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RNA detection in situ with FISH-STICs by Sinnamon, John R, Czaplinski, Kevin

“…The ability to detect RNA molecules in situ has long had important applications for molecular biological studies. Enzyme or dyelabeled antisense in vitro…”
Get full text