Search Results - "Sinn, B."

A randomised phase II study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple-negative breast cancer: clinical results and biomarker analysis of GeparNuevo study by Loibl, S., Untch, M., Burchardi, N., Huober, J., Sinn, B.V., Blohmer, J.-U., Grischke, E.-M., Furlanetto, J., Tesch, H., Hanusch, C., Engels, K., Rezai, M., Jackisch, C., Schmitt, W.D., von Minckwitz, G., Thomalla, J., Kümmel, S., Rautenberg, B., Fasching, P.A., Weber, K., Rhiem, K., Denkert, C., Schneeweiss, A.

“…Combining immune-checkpoint inhibitors with chemotherapy yielded an increased response rates in patients with metastatic triple-negative breast cancer (TNBC)…”
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Tumor mutational burden and immune infiltration as independent predictors of response to neoadjuvant immune checkpoint inhibition in early TNBC in GeparNuevo by Karn, T., Denkert, C., Weber, K.E., Holtrich, U., Hanusch, C., Sinn, B.V., Higgs, B.W., Jank, P., Sinn, H.P., Huober, J., Becker, C., Blohmer, J.-U., Marmé, F., Schmitt, W.D., Wu, S., van Mackelenbergh, M., Müller, V., Schem, C., Stickeler, E., Fasching, P.A., Jackisch, C., Untch, M., Schneeweiss, A., Loibl, S.

“…The predictive value of tumor mutational burden (TMB), alone or in combination with an immune gene expression profile (GEP), for response to neoadjuvant…”
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α-Smooth muscle actin expression and desmoplastic stromal reaction in pancreatic cancer: results from the CONKO-001 study by Sinn, M, Denkert, C, Striefler, J K, Pelzer, U, Stieler, J M, Bahra, M, Lohneis, P, Dörken, B, Oettle, H, Riess, H, Sinn, B V

“…Background: Previous investigations in pancreatic cancer suggest a prognostic role for α -smooth muscle actin ( α -SMA) expression and stromal density in the…”
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SPARC expression in resected pancreatic cancer patients treated with gemcitabine: results from the CONKO-001 study by Sinn, M., Sinn, B.V., Striefler, J.K., Lindner, J.L., Stieler, J.M., Lohneis, P., Bischoff, S., Bläker, H., Pelzer, U., Bahra, M., Dietel, M., Dörken, B., Oettle, H., Riess, H., Denkert, C.

“…Previous investigations in pancreatic cancer suggested a prognostic role for secreted protein acidic and rich in cysteine (SPARC) expression in the peritumoral…”
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A gene signature to predict high tumor-infiltrating lymphocytes after neoadjuvant chemotherapy and outcome in patients with triple-negative breast cancer by Criscitiello, C., Bayar, M.A., Curigliano, G., Symmans, F.W., Desmedt, C., Bonnefoi, H., Sinn, B., Pruneri, G., Vicier, C., Pierga, J.Y., Denkert, C., Loibl, S., Sotiriou, C., Michiels, S., André, F.

“…In patients with triple-negative breast cancer (TNBC), the extent of tumor-infiltrating lymphocytes (TILs) in the residual disease after neoadjuvant…”
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Reconstructing tumor history in breast cancer: signatures of mutational processes and response to neoadjuvant chemotherapy by Denkert, C., Untch, M., Benz, S., Schneeweiss, A., Weber, K.E., Schmatloch, S., Jackisch, C., Sinn, H.P., Golovato, J., Karn, T., Marmé, F., Link, T., Budczies, J., Nekljudova, V., Schmitt, W.D., Stickeler, E., Müller, V., Jank, P., Parulkar, R., Heinmöller, E., Sanborn, J.Z., Schem, C., Sinn, B.V., Soon-Shiong, P., van Mackelenbergh, M., Fasching, P.A., Rabizadeh, S., Loibl, S.

“…Different endogenous and exogenous mutational processes act over the evolutionary history of a malignant tumor, driven by abnormal DNA editing, mutagens or…”
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Human equilibrative nucleoside transporter 1 expression analysed by the clone SP 120 rabbit antibody is not predictive in patients with pancreatic cancer treated with adjuvant gemcitabine – Results from the CONKO-001 trial by Sinn, M, Riess, H, Sinn, B.V, Stieler, J.M, Pelzer, U, Striefler, J.K, Oettle, H, Bahra, M, Denkert, C, Bläker, H, Lohneis, P

“…Abstract Background High expression of human equilibrative nucleoside transporter 1 (hENT1) is considered to predict survival in patients treated with adjuvant…”
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Expression of secreted protein acidic and rich in cysteine (SPARC) in breast cancer and response to neoadjuvant chemotherapy by Lindner, J.L., Loibl, S., Denkert, C., Ataseven, B., Fasching, P.A., Pfitzner, B.M., Gerber, B., Gade, S., Darb-Esfahani, S., Sinn, B.V., Huober, J., Engels, K., Tesch, H., Karn, T., Pommerenke, F., Liedtke, C., Untch, M., Müller, V., Rack, B., Schem, C., von Minckwitz, G.

“…Secreted protein acidic and rich in cysteine (SPARC) has been suggested as a new biomarker and therapeutic target in breast cancer, as well as other tumor…”
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Evaluation of Mucin-1 protein and mRNA expression as prognostic and predictive markers after neoadjuvant chemotherapy for breast cancer by Sinn, B.V., von Minckwitz, G., Denkert, C., Eidtmann, H., Darb-Esfahani, S., Tesch, H., Kronenwett, R., Hoffmann, G., Belau, A., Thommsen, C., Holzhausen, H.J., Grasshoff, S.T., Baumann, K., Mehta, K., Dietel, M., Loibl, S.

“…Mucin-1 (MUC1) is a promising antigen for the development of tumor vaccines. We evaluated the frequency of MUC1 expression and its impact on therapy response…”
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RNA-based determination of ESR1 and HER2 expression and response to neoadjuvant chemotherapy by Denkert, C., Loibl, S., Kronenwett, R., Budczies, J., von Törne, C., Nekljudova, V., Darb-Esfahani, S., Solbach, C., Sinn, B.V., Petry, C., Müller, B.M., Hilfrich, J., Altmann, G., Staebler, A., Roth, C., Ataseven, B., Kirchner, T., Dietel, M., Untch, M., von Minckwitz, G.

“…Hormone and human epidermal growth factor receptor 2 (HER2) receptors are the most important breast cancer biomarkers, and additional objective and…”
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Final analysis of the Male-GBG54 study: A prospective, randomised multi-centre phase II study evaluating endocrine treatment with either tamoxifen +/- gonadotropin releasing hormone analogue (GnRHa) or an aromatase inhibitor + GnRHa in male breast cancer patients by Reinisch, M., Seiler, S., Hauzenberger, T., Schmatloch, S., Strittmatter, H.-J., Zahm, D.-M., Thode, C., Jackisch, C., Strik, D., Moebus, V., Reimer, T., Sinn, B., Stickeler, E., Marme, F., Janni, W., Kamischke, A., Rudlowski, C., Nekljudova, V., von Minckwitz, G., Loibl, S.

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SPARC expression in resected pancreatic cancer patients treated with Gemcitabine: results from the CONKO-001 study by Sinn, M, Sinn, B V, Striefler, J K, Lindner, J L, Stieler, J M, Lohneis, P, Bischoff, S, Bläker, H, Pelzer, U, Bahra, M, Dietel, M, Dörken, B, Oettle, H, Riess, H, Denkert, C

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Effects of Bacteriophages on the Population Dynamics of Four Strains of Pelagic Marine Bacteria by M. Middelboe, Hagström, A., N. Blackburn, B. Sinn, Fischer, U., N. H. Borch, J. Pinhassi, K. Simu, M. G. Lorenz

“…Viral lysis of specific bacterial populations has been suggested to be an important factor for structuring marine bacterioplankton communities. In the present…”
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Cryopreserved human amniotic membrane for ocular surface reconstruction by KRUSE, F. E, JOUSSEN, A. M, ROHRSCHNEIDER, K, LINGTAO YOU, SINN, B, BAUMANN, J, VÖLCKER, H. E

“…Amniotic membrane transplantation is used for the reconstruction of the ocular surface in the context of, for example, corneal ulcers or conjunctival scarring…”
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Processing and high strain rate impact response of multi-functional sandwich composites by Vaidya, U.K, Nelson, S, Sinn, B, Mathew, B

“…Sandwich composites are finding increasing applications in aerospace, marine and commercial structures because they offer high bending stiffness and…”
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Precise measurement of protein interacting fractions with fluorescence lifetime imaging microscopy by Walther, Kirstin A, Papke, Björn, Sinn, Maja B, Michel, Kirsten, Kinkhabwala, Ali

“…Precise quantification of endogenous protein-protein interactions across live cells would be a major boon to biology. Such precise measurement is theoretically…”
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Radiation-induced apoptosis in human non-small-cell lung cancer cell lines is secondary to cell-cycle progression beyond the G2-phase checkpoint by Stuschke, M., Sak, A., Wurm, R., Sinn, B., Wolf, G., Stüben, G., Budach, V.

“…Purpose : To characterize the relationship between cell-cycle progression and radiation-induced apoptosis in NSCLC cell lines with different p53 status…”
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177P TP53 and PRBM1 mutations predict “hot” tumor microenvironment in intrahepatic cholangiocarcinoima by Lozzi Da Costa, I., Sinn, B., Arnold, A., Andreou, A., Felsenstein, M., Schirmeier, A., Reutzel-Selke, A., Pratschke, J., Sauer, I.M., Feist, M.

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The novel synthetic inhibitor of matrix metalloproteinases Ro 28-2653 induces apoptosis in Dunning tumor cells by Mangoldt, D, Sinn, B, Lein, M, Krell, H W, Schnorr, D, Loening, S A, Jung, K

“…The effect of synthetic inhibitors of matrix metalloproteinases (MMP) has been shown against a variety of tumors in preclinical models. Ro 28-2653, a novel…”
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17P Impact of body mass index (BMI) on prognostic and predictive value of stromal tumour-infiltrating lymphocytes (sTILs) in triple-negative breast cancer (TNBC): A pooled analysis of six neoadjuvant trials by Furlanetto, J., Denkert, C., Untch, M., Sinn, B., Lederer, B., Schneeweiss, A., Mueller, V., van Mackelenbergh, M., Stickeler, E., Fasching, P.A., Schem, C., Karn, T., Marmé, F., Nekljudova, V., Loibl, S.

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