Search Results - "Sinitski, Dzmitry"

Macrophage Migration Inhibitory Factor (MIF)-Based Therapeutic Concepts in Atherosclerosis and Inflammation by Sinitski, Dzmitry, Kontos, Christos, Krammer, Christine, Asare, Yaw, Kapurniotu, Aphrodite, Bernhagen, Jürgen

“…Chemokines orchestrate leukocyte recruitment in atherosclerosis and their blockade is a promising anti-atherosclerotic strategy, but few chemokine-based…”
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Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells by Spiller, Lukas, Manjula, Ramu, Leissing, Franz, Basquin, Jerome, Bourilhon, Priscila, Sinitski, Dzmitry, Brandhofer, Markus, Levecque, Sophie, Gerra, Simona, Sabelleck, Björn, Zhang, Lin, Feederle, Regina, Flatley, Andrew, Hoffmann, Adrian, Panstruga, Ralph, Bernhagen, Jürgen, Lolis, Elias

“…Mammalian macrophage migration inhibitory factor (MIF) and its paralog, D-dopachrome tautomerase, are multifunctional inflammatory cytokines. Plants have…”
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CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia by Thavayogarajah, Tharshika, Sinitski, Dzmitry, El Bounkari, Omar, Torres-Garcia, Laura, Lewinsky, Hadas, Harjung, Alexander, Chen, Hong-Ru, Panse, Jens, Vankann, Lucia, Shachar, Idit, Bernhagen, Jürgen, Koschmieder, Steffen

“…•CXCR4 and CD74 are coexpressed and increased on B cells in CLL patients.•CXCR4 and CD74 collaborate to enhance survival of malignant B cells in CLL.•CXCR4 and…”
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Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4 by Lacy, Michael, Kontos, Christos, Brandhofer, Markus, Hille, Kathleen, Gröning, Sabine, Sinitski, Dzmitry, Bourilhon, Priscila, Rosenberg, Eric, Krammer, Christine, Thavayogarajah, Tharshika, Pantouris, Georgios, Bakou, Maria, Weber, Christian, Lolis, Elias, Bernhagen, Jürgen, Kapurniotu, Aphrodite

“…MIF is a chemokine-like cytokine that plays a role in the pathogenesis of inflammatory and cardiovascular disorders. It binds to the chemokine-receptors…”
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Co-Expression and Functional Interaction between CXCR4 and CD74 in Chronic Lymphocytic Leukemia by Thavayogarajah, Tharshika, Sinitski, Dzmitry, Panse, Jens P., Shachar, Idit, Brümmendorf, Tim H., Bernhagen, Jürgen, Koschmieder, Steffen

“…Chronic lymphocytic leukemia (CLL) is characterized by progressive accumulation of small, mature B-lymphocytes aberrantly expressing CD5. One of the crucial…”
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Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs by Sinitski, Dzmitry, Gruner, Katrin, Brandhofer, Markus, Kontos, Christos, Winkler, Pascal, Reinstädler, Anja, Bourilhon, Priscila, Xiao, Zhangping, Cool, Robbert, Kapurniotu, Aphrodite, Dekker, Frank J., Panstruga, Ralph, Bernhagen, Jürgen

“…Human macrophage migration-inhibitory factor (MIF) is an evolutionarily-conserved protein that has both extracellular immune-modulating and intracellular…”
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Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo by Asare, Yaw, Ommer, Miriam, Azombo, Florence. A., Alampour-Rajabi, Setareh, Sternkopf, Marieke, Sanati, Maryam, Gijbels, Marion J., Schmitz, Corinna, Sinitski, Dzmitry, Tilstam, Pathricia V., Lue, Hongqi, Gessner, André, Lange, Denise, Schmid, Johannes A., Weber, Christian, Dichgans, Martin, Jankowski, Joachim, Pardi, Ruggero, de Winther, Menno P. J., Noels, Heidi, Bernhagen, Jürgen

“…Constitutive photomorphogenesis 9 (COP9) signalosome 5 (CSN5), an isopeptidase that removes neural precursor cell-expressed, developmentally down-regulated 8…”
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Chemokine-like MDL proteins modulate flowering time and innate immunity in plants by Gruner, Katrin, Leissing, Franz, Sinitski, Dzmitry, Thieron, Hannah, Axstmann, Christian, Baumgarten, Kira, Reinstädler, Anja, Winkler, Pascal, Altmann, Melina, Flatley, Andrew, Jaouannet, Maëlle, Zienkiewicz, Krzysztof, Feussner, Ivo, Keller, Harald, Coustau, Christine, Falter-Braun, Pascal, Feederle, Regina, Bernhagen, Jürgen, Panstruga, Ralph

“…Human macrophage migration inhibitory factor (MIF) is an atypical chemokine implicated in intercellular signaling and innate immunity. MIF orthologs…”
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Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting by Kontos, Christos, El Bounkari, Omar, Krammer, Christine, Sinitski, Dzmitry, Hille, Kathleen, Zan, Chunfang, Yan, Guangyao, Wang, Sijia, Gao, Ying, Brandhofer, Markus, Megens, Remco T. A., Hoffmann, Adrian, Pauli, Jessica, Asare, Yaw, Gerra, Simona, Bourilhon, Priscila, Leng, Lin, Eckstein, Hans-Henning, Kempf, Wolfgang E., Pelisek, Jaroslav, Gokce, Ozgun, Maegdefessel, Lars, Bucala, Richard, Dichgans, Martin, Weber, Christian, Kapurniotu, Aphrodite, Bernhagen, Jürgen

“…Targeting a specific chemokine/receptor axis in atherosclerosis remains challenging. Soluble receptor-based strategies are not established for chemokine…”
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A MIF‐Derived Cyclopeptide that Inhibits MIF Binding and Atherogenic Signaling via the Chemokine Receptor CXCR2 by Krammer, Christine, Kontos, Christos, Dewor, Manfred, Hille, Kathleen, Dalla Volta, Beatrice, El Bounkari, Omar, Taş, Karin, Sinitski, Dzmitry, Brandhofer, Markus, Megens, Remco T. A., Weber, Christian, Schultz, Joshua R., Bernhagen, Jürgen, Kapurniotu, Aphrodite

“…Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine and atypical chemokine with a key role in inflammatory diseases including…”
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Cross-kingdom mimicry of the receptor signaling and leukocyte recruitment activity of a human cytokine by its plant orthologs by Sinitski, Dzmitry, Gruner, Katrin, Brandhofer, Markus, Kontos, Christos, Winkler, Pascal, Reinstädler, Anja, Bourilhon, Priscila, Xiao, Zhangping, Cool, Robbert, Kapurniotu, Aphrodite, Dekker, Frank J., Panstruga, Ralph, Bernhagen, Jürgen

“…Human macrophage migration-inhibitory factor (MIF) is an evolutionarily-conserved protein that has both extracellular immune-modulating and intracellular…”
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Studying Plant MIF/D-DT-Like Genes and Proteins (MDLs) by Sinitski, Dzmitry, Gruner, Katrin, Bernhagen, Jürgen, Panstruga, Ralph

“…Human macrophage migration inhibitory factor (MIF) is an inflammatory cytokine with chemokine-like characteristics and an upstream regulator of host innate…”
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Early Staphylococcus aureus -induced changes in endothelial barrier function are strain-specific and unrelated to bacterial translocation by Kramko, Nadzeya, Sinitski, Dzmitry, Seebach, Jochen, Löffler, Bettina, Dieterich, Peter, Heilmann, Christine, Peters, Georg, Schnittler, Hans-Joachim

“…Abstract The vascular endothelium provides the critical barrier during hematogenous spreading of bacteria, a phenomenon that might contribute to severe…”
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